The 2018 SCOR Young European Researcher Prize for research into Alzheimer’s disease was awarded to Rik Ossenkoppele of the Alzheimer Center at the VU University Medical Center in Amsterdam, the Netherlands.

A Dutch-born Doctor of Science, he is considered one of the most brilliant researchers of his generation. His main work has focused on new neuroimaging tracers – both amyloid markers and tau markers – that make it possible to identify lesions in patients’ brains during a PET scan.

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Rik Ossenkoppele, 6th winner of the SCOR Young European Researcher Prize for Alzheimer Disease

He has also done some remarkable work on cerebrospinal fluid markers. The SCOR Young European Researcher Prize, in association with the French Alzheimer’s Research Foundation, has thus been awarded to a leading expert on Alzheimer’s disease biomarkers.

Rik Ossenkoppele on the French Alzheimer’s Research Foundation (Fondation Recherche Alzheimer) website.

Publications by Rik Ossenkoppele

• Amyloid-β-independent regulators of tau pathology in Alzheimer disease.
  van der Kant R, Goldstein LSB, Ossenkoppele R. Nat Rev Neurosci.
  2020 Jan;21(1):21-35. doi: 10.1038/s41583-019-0240-3. Epub 2019 Nov 28. PMID: 31780819 Review.
• Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias.
  Chételat G, Arbizu J, Barthel H, Garibotto V, Law I, Morbelli S, van de Giessen E, Agosta F, Barkhof F, Brooks DJ, Carrillo MC, Dubois B, Fjell AM, Frisoni GB, Hansson O, Herholz K, Hutton BF, Jack CR Jr, Lammertsma AA, Landau SM, Minoshima S, Nobili F, Nordberg A, Ossenkoppele R, Oyen WJG, Perani D, Rabinovici GD, Scheltens P, Villemagne VL, Zetterberg H, Drzezga A. Lancet Neurol.
  2020 Nov;19(11):951-962. doi: 10.1016/S1474-4422(20)30314-8. PMID: 33098804 Review.
• Clinicopathological correlations in behavioural variant frontotemporal dementia.
  Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW. Brain.
  2017 Dec 1;140(12):3329-3345. doi: 10.1093/brain/awx254. PMID: 29053860 Free PMC article.
• The effect of physical activity on cognitive function in patients with dementia: A meta-analysis of randomized control trials.
  Groot C, Hooghiemstra AM, Raijmakers PG, van Berckel BN, Scheltens P, Scherder EJ, van der Flier WM, Ossenkoppele R.
  Ageing Res Rev. 2016 Jan;25:13-23. doi: 10.1016/j.arr.2015.11.005. Epub 2015 Nov 28. PMID: 26607411 Review.
• Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
  Jansen WJ, Ossenkoppele R, Knol DL, Tijms BM, Scheltens P, Verhey FR, Visser PJ; Amyloid Biomarker Study Group, Aalten P, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BN, Bibeau K, Blennow K, Brooks DJ, van Buchem MA, Camus V, Cavedo E, Chen K, Chetelat G, Cohen AD, Drzezga A, Engelborghs S, Fagan AM, Fladby T, Fleisher AS, van der Flier WM, Ford L, Förster S, Fortea J, Foskett N, Frederiksen KS, Freund-Levi Y, Frisoni GB, Froelich L, Gabryelewicz T, Gill KD, Gkatzima O, Gómez-Tortosa E, Gordon MF, Grimmer T, Hampel H, Hausner L, Hellwig S, Herukka SK, Hildebrandt H, Ishihara L, Ivanoiu A, Jagust WJ, Johannsen P, Kandimalla R, Kapaki E, Klimkowicz-Mrowiec A, Klunk WE, Köhler S, Koglin N, Kornhuber J, Kramberger MG, Van Laere K, Landau SM, Lee DY, de Leon M, Lisetti V, Lleó A, Madsen K, Maier W, Marcusson J, Mattsson N, de Mendonça A, Meulenbroek O, Meyer PT, Mintun MA, Mok V, Molinuevo JL, Møllergård HM, Morris JC, Mroczko B, Van der Mussele S, Na DL, Newberg A, Nordberg A, Nordlund A, Novak GP, Paraskevas GP, Parnetti L, Perera G, Peters O, Popp J, Prabhakar S, Rabinovici GD, Ramakers IH, Rami L, Resende de Oliveira C, Rinne JO, Rodrigue KM, Rodríguez-Rodríguez E, Roe CM, Rot U, Rowe CC, Rüther E, Sabri O, Sanchez-Juan P, Santana I, Sarazin M, Schröder J, Schütte C, Seo SW, Soetewey F, Soininen H, Spiru L, Struyfs H, Teunissen CE, Tsolaki M, Vandenberghe R, Verbeek MM, Villemagne VL, Vos SJ, van Waalwijk van Doorn LJ, Waldemar G, Wallin A, Wallin ÅK, Wiltfang J, Wolk DA, Zboch M, Zetterberg H. JAMA.
  2015 May 19;313(19):1924-38. doi: 10.1001/jama.2015.4668. PMID: 25988462 Free PMC article.
• Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease.
  Franzmeier N, Neitzel J, Rubinski A, Smith R, Strandberg O, Ossenkoppele R, Hansson O, Ewers M; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Nat Commun.
  2020 Jan 17;11(1):347. doi: 10.1038/s41467-019-14159-1. PMID: 31953405 Free PMC article.
• PET Imaging of Tau Deposition in the Aging Human Brain.
  Schöll M, Lockhart SN, Schonhaut DR, O'Neil JP, Janabi M, Ossenkoppele R, Baker SL, Vogel JW, Faria J, Schwimmer HD, Rabinovici GD, Jagust WJ. Neuron.
  2016 Mar 2;89(5):971-982. doi: 10.1016/j.neuron.2016.01.028. PMID: 26938442 Free PMC article.
• The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features.
  Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, La Joie R, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel BN, Miller BL, Barkhof F, Jagust WJ, Scheltens P, Seeley WW, Rabinovici GD. Brain.
  2015 Sep;138(Pt 9):2732-49. doi: 10.1093/brain/awv191. Epub 2015 Jul 2. PMID: 26141491 Free PMC article.
• Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship.
  van Loenhoud AC, van der Flier WM, Wink AM, Dicks E, Groot C, Twisk J, Barkhof F, Scheltens P, Ossenkoppele R; Alzheimer's Disease Neuroimaging Initiative. Neurology.
  2019 Jul 23;93(4):e334-e346. doi: 10.1212/WNL.0000000000007821. Epub 2019 Jul 2. PMID: 31266904 Free PMC article.
• Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.
  Bergeron D, Gorno-Tempini ML, Rabinovici GD, Santos-Santos MA, Seeley W, Miller BL, Pijnenburg Y, Keulen MA, Groot C, van Berckel BNM, van der Flier WM, Scheltens P, Rohrer JD, Warren JD, Schott JM, Fox NC, Sanchez-Valle R, Grau-Rivera O, Gelpi E, Seelaar H, Papma JM, van Swieten JC, Hodges JR, Leyton CE, Piguet O, Rogalski EJ, Mesulam MM, Koric L, Nora K, Pariente J, Dickerson B, Mackenzie IR, Hsiung GR, Belliard S, Irwin DJ, Wolk DA, Grossman M, Jones M, Harris J, Mann D, Snowden JS, Chrem-Mendez P, Calandri IL, Amengual AA, Miguet-Alfonsi C, Magnin E, Magnani G, Santangelo R, Deramecourt V, Pasquier F, Mattsson N, Nilsson C, Hansson O, Keith J, Masellis M, Black SE, Matías-Guiu JA, Cabrera-Martin MN, Paquet C, Dumurgier J, Teichmann M, Sarazin M, Bottlaender M, Dubois B, Rowe CC, Villemagne VL, Vandenberghe R, Granadillo E, Teng E, Mendez M, Meyer PT, Frings L, Lleó A, Blesa R, Fortea J, Seo SW, Diehl-Schmid J, Grimmer T, Frederiksen KS, Sánchez-Juan P, Chételat G, Jansen W, Bouchard RW, Laforce RJ, Visser PJ, Ossenkoppele R. Ann Neurol.
  2018 Nov;84(5):729-740. doi: 10.1002/ana.25333. PMID: 30255971 Free PMC article.

More publications by Rik Ossenkoppele are available on the National Library of Medicine website.