SCOR Young European Researcher Prize for research into Alzheimer’s disease

SCOR Young European Researcher Prize for research into Alzheimer’s disease

The SCOR Corporate Foundation for Science is proud to support France’s Alzheimer’s Research Foundation through this SCOR Young European Researcher Prize.

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Extending and reinforcing a partnership initiated by SCOR in 2008, the SCOR Corporate Foundation for Science signed a sponsorship agreement with the research program of France’s Alzheimer’s Research Foundation (Fondation Recherche Alzheimer) on June 12, 2013. As well as creating an annual award for young European researchers, the agreement enables the Research Foundation to continue observing a cohort of patients as part of a long-term study of Alzheimer’s sufferers, and to promote cooperative research in this field with scientists from other countries.

 

Florence Clavaguera, winner of the first award in 2013,
talks about how the prize changed her career.

 

2021

Axel MontagneFrench researcher Axel Montagne won the award for his research on how cerebrovascular dysfunction contributes to neurodegeneration and cognitive impairment in animal models and humans. In the context of neurodegenerative diseases, he studies the causes and effects of dysfunction of the blood-brain barrier, the main function of which is to isolate the central nervous system from the bloodstream, preventing potentially toxic foreign substances from entering the brain. Axel Montagne has been a Chancellor’s Fellow at the University of Edinburgh Centre for Clinical Brain Sciences since December 2020, leading a research group at the UK Dementia Research Institute. In 2012, he obtained a PhD in Neuroscience/Neuroimaging from the University of Caen. He then joined the University of Southern California (USC) in Los Angeles for a post-doctorate, before becoming an Assistant Professor in 2016 and then Associate Professor in 2020.

 

 

 

2020

renzo mancuso

The seventh SCOR Young European Researcher Prize for Research into Alzheimer’s disease was awarded to Renzo Marcuso of the Gothenburg University in Sweden. Renzo won the award for his findings on microglia and neuroinflammation, which play a central role in the pathogenesis of Alzheimer’s disease and other neurodegenerative disorders. A young Italian-Argentine biologist, Renzo Marcuso works with Pr. Bart de Strooper at the VIB UAntwerp Center for Molecular Neurology in the Netherlands. His primary focus has been on examining the underlying molecular mechanisms that drive Alzheimer’s disease (AD) and frontotemporal degeneration (FTD), with a special emphasis on inflammatory networks and particularly the contribution of microglia. He uses mouse models, iPSC and cutting-edge humanized mouse systems to determine the immune component of these disorders and determine how genetics alter microglial function and contribute to the initiation and perpetuation of brain disease. Click here for more information and here to read Renzo's entry form.

 

2019

The 2019 SCOR Young European Researcher Prize for Research into Alzheimer’s disease was awarded to Dr Federica Agosa, medical doctor and researcher at the San Raffaele Hospital in Milan. Using MRI (magnetic resonance imaging) techniques, her work aims to identify functional and structural markers of degeneration to enable early diagnosis of Alzheimer’s and related disorders. She is also particularly interested in young-onset Alzheimer’s disease. She has published more than 200 articles in specialist scientific journals. The jury of renowned European researchers was chaired by Professor Jean-François Dartigues of the Bordeaux Population Health Research Center.
Commenting on the award, André Levy-Lang, Chairman of the SCOR Foundation for Science, said: “Advances in Alzheimer’s disease research, which the SCOR Foundation has supported for many years, play a key role in managing the risks faced by older age groups. Dr Agosta’s research is helping more specifically to pursue the age-old goal of prolonging life expectancy.”

 

 

2018

On February 12, 2018, the 5th SCOR Young European Researcher Prize for Research into Alzheimer’s disease was presented to Erik Portelius of Sweden’s Gothenburg University, for his findings on a new biomarker that enables earlier detection of the condition. 
This new biomarker, a protein called neurogranin, paves the way for a better understanding of the disease. It allows doctors to estimate the extent of the damage to patients’ synapses and also to predict the rate of cognitive decline in patients with mild cognitive impairment. By measuring the new biomarker, the disease can be detected at an earlier stage than previously, since the loss of synapses is believed to occur early in the disease process, perhaps even earlier than neuronal loss. Until now, the degree of neuronal loss has been a difficult thing to identify in Alzheimer’s sufferers. The measurement of neurogranin, which will soon be implemented as part of a routine clinical analysis at the Clinical Neurochemistry Laboratory in Gothenburg, Sweden, involves extracting cerebrospinal fluid during a harmless lumbar puncture or spinal tap, which is then tested for the neurogranin protein. Click here for more information.

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2017

 4th_prize_alzheimer_research_galaalzheimer_nmattsonThe Scientific Committee of the French Alzheimer’s Research Foundation, comprised of eight European neurology professors, has named Dr. Niklas Mattson of Sweden’s Lund University as the winner of the 4th SCOR Young European Researcher Prize, which is financed by the SCOR Corporate Foundation for Science.
Dr. Niklas Mattson’s original research on biomarkers has improved medical knowledge of disease mechanisms in the early stages of Alzheimer’s disease.
A biomarker can be defined as “a naturally occurring molecule, gene, or characteristic by which a particular pathological or physiological process, disease, etc. can be identified”. Proteins or other molecules found in fluids such as blood or cerebrospinal fluid can constitute biomarkers, as can physiological or anatomical changes observed using techniques such as functional magnetic resonance imaging (fMRI), which uses MRI technology to measure brain activity by detecting changes associated with blood flow, and positron-emission tomography (PET), a scan that uses a radioactive substance called a tracer to look for disease in the body. Click here for more information.

 

2016 

3rd_Alzheimer_prize_Lawrence_Rajendran - leftThe 3rd SCOR Young European Researcher Prize, financed by the SCOR Corporate Foundation for Science, was awarded to Dr Lawrence Rajendran of the University of Zurich.
Lawrence Rajendran’s remarkable work notably deals with the genes that predispose people to develop Alzheimer’s disease. For neurodegenerative diseases it is often impossible to isolate one responsible gene, which was previously the case for Alzheimer’s disease. However, the emergence of functional genomics methods and computational tools has led to advances in the understanding of the complex molecular networks underlying the disease.

Lawrence Rajendran’s work also deals with the link between food and the development of neurodegenerative diseases. Consuming too much protein, which is found for example in red meat, incites the brain to use this source of energy instead of consuming the proteins present in its own cells. This overconsumption encourages an accumulation of abnormal proteins in the brain’s cells. These amyloid proteins formed in the brain play a role in the development of Alzheimer’s disease. Aside from nutritional recommendations, Lawrence Rajendran’s work opens the way to possible medical developments, with the use of medication that encourages the brain to refuse this external source of protein and focus instead on its own resources. Click here for more information.

Publications by the prizewinners
Accordion

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline
Axel Montagne, May 2020. 8th SCOR Young European Researcher Prize for Alzheimer’s Research.

Axel Montagne, Daniel A. Nation, Abhay P. Sagare, Giuseppe Barisano, Melanie D. Sweeney, Ararat Chakhoyan, Maricarmen Pachicano, Elizabeth Joe, Amy R. Nelson, Lina M. D’Orazio, David P. Buennage, Michael G. Harrington, Tammie L. S. Benzinger, Anne M. Fagan, John M. Ringman, Lon S. Schneider, John C. Morris, Eric M. Reiman, Richard J. Caselli, Helena C. Chui, Julia, Yining Chen, Judy Pa, Peter S. Conti, Meng Law, Arthur W. Toga, Berislav V. Zlokovic. 
Published in final edited form as: Nature. 2020 May; 581(7806): 71–76. PMCID: PMC7250000 NIHMSID: NIHMS1581356 PMID: 32376954

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.
Chen WT, Lu A, Craessaerts K, Pavie B, Sala Frigerio C, Corthout N, Qian X, Laláková J, Kühnemund M, Voytyuk I, Wolfs L, Mancuso R, Salta E, Balusu S, Snellinx A, Munck S, Jurek A, Fernandez Navarro J, Saido TC, Huitinga I, Lundeberg J, Fiers M, De Strooper B. Cell. 2020 Aug 20;182(4):976-991.e19. doi: 10.1016/j.cell.2020.06.038. Epub 2020 Jul 22. PMID: 32702314

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Pasciuto E, Burton OT, Roca CP, Lagou V, Rajan WD, Theys T, Mancuso R, Tito RY, Kouser L, Callaerts-Vegh Z, de la Fuente AG, Prezzemolo T, Mascali LG, Brajic A, Whyte CE, Yshii L, Martinez-Muriana A, Naughton M, Young A, Moudra A, Lemaitre P, Poovathingal S, Raes J, De Strooper B, Fitzgerald DC, Dooley J, Liston A. Cell. 2020 Aug 6;182(3):625-640.e24. doi: 10.1016/j.cell.2020.06.026. Epub 2020 Jul 22. PMID: 32702313 Free PMC article.

Stem-cell-derived human microglia transplanted in mouse brain to study human disease.
Mancuso R, Van Den Daele J, Fattorelli N, Wolfs L, Balusu S, Burton O, Liston A, Sierksma A, Fourne Y, Poovathingal S, Arranz-Mendiguren A, Sala Frigerio C, Claes C, Serneels L, Theys T, Perry VH, Verfaillie C, Fiers M, De Strooper B. Nat Neurosci. 2019 Dec;22(12):2111-2116. doi: 10.1038/s41593-019-0525-x. Epub 2019 Oct 28. PMID: 31659342

The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.
Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, Hyman B, Perry VH, Fiers M, De Strooper B. Cell Rep. 2019 Apr 23;27(4):1293-1306.e6. doi: 10.1016/j.celrep.2019.03.099. PMID: 31018141 Free PMC article.

Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology.
Sierksma A, Lu A, Mancuso R, Fattorelli N, Thrupp N, Salta E, Zoco J, Blum D, Buée L, De Strooper B, Fiers M. EMBO Mol Med. 2020 Mar 6;12(3):e10606. doi: 10.15252/emmm.201910606. Epub 2020 Jan 17. PMID: 31951107 Free PMC article.

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans.
Thrupp N, Sala Frigerio C, Wolfs L, Skene NG, Fattorelli N, Poovathingal S, Fourne Y, Matthews PM, Theys T, Mancuso R, de Strooper B, Fiers M. Cell Rep. 2020 Sep 29;32(13):108189. doi: 10.1016/j.celrep.2020.108189. PMID: 32997994 Free PMC article.

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón-Sandoval J, Ribe E, Winchester L, Webber C, Nevado A, Jacobs T, Austin N, Theunis C, Grauwen K, Daniela Ruiz E, Mudher A, Vicente-Rodriguez M, Parker CA, Simmons C, Cash D, Richardson J; NIMA Consortium, Jones DNC, Lovestone S, Gómez-Nicola D, Perry VH. Brain. 2019 Oct 1;142(10):3243-3264. doi: 10.1093/brain/awz241. PMID: 31504240 Free PMC article.

Inflammatory biomarkers in Alzheimer's disease plasma.
Morgan AR, Touchard S, Leckey C, O'Hagan C, Nevado-Holgado AJ; NIMA Consortium, Barkhof F, Bertram L, Blin O, Bos I, Dobricic V, Engelborghs S, Frisoni G, Frölich L, Gabel S, Johannsen P, Kettunen P, Kłoszewska I, Legido-Quigley C, Lleó A, Martinez-Lage P, Mecocci P, Meersmans K, Molinuevo JL, Peyratout G, Popp J, Richardson J, Sala I, Scheltens P, Streffer J, Soininen H, Tainta-Cuezva M, Teunissen C, Tsolaki M, Vandenberghe R, Visser PJ, Vos S, Wahlund LO, Wallin A, Westwood S, Zetterberg H, Lovestone S, Morgan BP; Annex: NIMA–Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer's Disease. Alzheimers Dement. 2019 Jun;15(6):776-787. doi: 10.1016/j.jalz.2019.03.007. Epub 2019 Apr 30. PMID: 31047856 Free PMC article.

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology.
Olmos-Alonso A, Schetters ST, Sri S, Askew K, Mancuso R, Vargas-Caballero M, Holscher C, Perry VH, Gomez-Nicola D. Brain. 2016 Mar;139(Pt 3):891-907. doi: 10.1093/brain/awv379. Epub 2016 Jan 8. PMID: 26747862 Free PMC article.

Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1G93A mice.
Martínez-Muriana A, Pastor D, Mancuso R, Rando A, Osta R, Martínez S, López-Vales R, Navarro X. Stem Cell Res Ther. 2020 Feb 7;11(1):53. doi: 10.1186/s13287-020-1573-6. PMID: 32033585 Free PMC article.

Sigma-1 Receptor in Motoneuron Disease.
Mancuso R, Navarro X. Adv Exp Med Biol. 2017;964:235-254. doi: 10.1007/978-3-319-50174-1_16. PMID: 28315275 Review.

The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity.
Obst J, Simon E, Mancuso R, Gomez-Nicola D. Front Aging Neurosci. 2017 Jun 23;9:207. doi: 10.3389/fnagi.2017.00207. eCollection 2017. PMID: 28690540 Free PMC article. Review.

Amyotrophic lateral sclerosis: Current perspectives from basic research to the clinic.
Mancuso R, Navarro X. Prog Neurobiol. 2015 Oct;133:1-26. doi: 10.1016/j.pneurobio.2015.07.004. Epub 2015 Aug 5. PMID: 26253783 Review.

Prochlorperazine Increases KCC2 Function and Reduces Spasticity after Spinal Cord Injury.
Liabeuf S, Stuhl-Gourmand L, Gackière F, Mancuso R, Sanchez Brualla I, Marino P, Brocard F, Vinay L. J Neurotrauma. 2017 Dec 15;34(24):3397-3406. doi: 10.1089/neu.2017.5152. Epub 2017 Sep 19. PMID: 28747093

Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation.
Clayton EL, Mancuso R, Nielsen TT, Mizielinska S, Holmes H, Powell N, Norona F, Larsen JO, Milioto C, Wilson KM, Lythgoe MF, Ourselin S, Nielsen JE, Johannsen P, Holm I, Collinge J; FReJA, Oliver PL, Gomez-Nicola D, Isaacs AM. Hum Mol Genet. 2017 Mar 1;26(5):873-887. doi: 10.1093/hmg/ddx003. PMID: 28093491 Free PMC article.

Evolution of gait abnormalities in SOD1(G93A) transgenic mice.
Mancuso R, Oliván S, Osta R, Navarro X. Brain Res. 2011 Aug 11;1406:65-73. doi: 10.1016/j.brainres.2011.06.033. Epub 2011 Jul 5. PMID: 21733494

Presymptomatic electrophysiological tests predict clinical onset and survival in SOD1(G93A) ALS mice.
Mancuso R, Osta R, Navarro X. Muscle Nerve. 2014 Dec;50(6):943-9. doi: 10.1002/mus.24237. Epub 2014 Oct 30. PMID: 24619579

Stem-cell-derived human microglia transplanted into mouse brain to study human disease.
Fattorelli N, Martinez-Muriana A, Wolfs L, Geric I, De Strooper B, Mancuso R. Nat Protoc. 2021 Feb;16(2):1013-1033. doi: 10.1038/s41596-020-00447-4. Epub 2021 Jan 11. PMID: 33424025

Resveratrol improves motoneuron function and extends survival in SOD1(G93A) ALS mice.
Mancuso R, del Valle J, Modol L, Martinez A, Granado-Serrano AB, Ramirez-Núñez O, Pallás M, Portero-Otin M, Osta R, Navarro X. Neurotherapeutics. 2014 Apr;11(2):419-32. doi: 10.1007/s13311-013-0253-y. PMID: 24414863 Free PMC article.

Neuregulin-1 promotes functional improvement by enhancing collateral sprouting in SOD1(G93A) ALS mice and after partial muscle denervation.
Mancuso R, Martínez-Muriana A, Leiva T, Gregorio D, Ariza L, Morell M, Esteban-Pérez J, García-Redondo A, Calvo AC, Atencia-Cibreiro G, Corfas G, Osta R, Bosch A, Navarro X. Neurobiol Dis. 2016 Nov;95:168-78. doi: 10.1016/j.nbd.2016.07.023. Epub 2016 Jul 25. PMID: 27461051

Bone marrow transplantation in dysferlin-deficient mice results in a mild functional improvement.
Flix B, Suárez-Calvet X, Díaz-Manera J, Santos-Nogueira E, Mancuso R, Barquinero J, Navas M, Navarro X, Illa I, Gallardo E. Stem Cells Dev. 2013 Nov 1;22(21):2885-94. doi: 10.1089/scd.2013.0049. Epub 2013 Jul 26. PMID: 23777246 Free PMC article.

Electrophysiological analysis of a murine model of motoneuron disease.
Mancuso R, Santos-Nogueira E, Osta R, Navarro X. Clin Neurophysiol. 2011 Aug;122(8):1660-70. doi: 10.1016/j.clinph.2011.01.045. Epub 2011 Feb 25. PMID: 21354365

Differential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons.
Mòdol L, Mancuso R, Alé A, Francos-Quijorna I, Navarro X. Front Cell Neurosci. 2014 Jan 24;8:7. doi: 10.3389/fncel.2014.00007. eCollection 2014. PMID: 24478630 Free PMC article.

Early presymptomatic cholinergic dysfunction in a murine model of amyotrophic lateral sclerosis.
Casas C, Herrando-Grabulosa M, Manzano R, Mancuso R, Osta R, Navarro X. Brain Behav. 2013 Mar;3(2):145-58. doi: 10.1002/brb3.104. Epub 2013 Feb 17. PMID: 23531559 Free PMC article.

CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves.
Martínez-Muriana A, Mancuso R, Francos-Quijorna I, Olmos-Alonso A, Osta R, Perry VH, Navarro X, Gomez-Nicola D, López-Vales R. Sci Rep. 2016 May 13;6:25663. doi: 10.1038/srep25663. PMID: 27174644 Free PMC article.

Sigma-1R agonist improves motor function and motoneuron survival in ALS mice.
Mancuso R, Oliván S, Rando A, Casas C, Osta R, Navarro X. Neurotherapeutics. 2012 Oct;9(4):814-26. doi: 10.1007/s13311-012-0140-y. PMID: 22935988 Free PMC article.

Wnt Signaling Alteration in the Spinal Cord of Amyotrophic Lateral Sclerosis Transgenic Mice: Special Focus on Frizzled-5 Cellular Expression Pattern.
González-Fernández C, Mancuso R, Del Valle J, Navarro X, Rodríguez FJ. PLoS One. 2016 May 18;11(5):e0155867. doi: 10.1371/journal.pone.0155867. eCollection 2016. PMID: 27192435 Free PMC article.

Randall-Selitto test: a new approach for the detection of neuropathic pain after spinal cord injury.
Santos-Nogueira E, Redondo Castro E, Mancuso R, Navarro X. J Neurotrauma. 2012 Mar 20;29(5):898-904. doi: 10.1089/neu.2010.1700. Epub 2011 Oct 11. PMID: 21682605 Free PMC article.

Effect of genetic background on onset and disease progression in the SOD1-G93A model of amyotrophic lateral sclerosis.
Mancuso R, Oliván S, Mancera P, Pastén-Zamorano A, Manzano R, Casas C, Osta R, Navarro X. Amyotroph Lateral Scler. 2012 May;13(3):302-10. doi: 10.3109/17482968.2012.662688. Epub 2012 Mar 16. PMID: 22424126

Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G⁹³A ALS mice: overlapping effects or limited therapeutic opportunity?
Mancuso R, Del Valle J, Morell M, Pallás M, Osta R, Navarro X. Orphanet J Rare Dis. 2014 May 21;9:78. doi: 10.1186/1750-1172-9-78. PMID: 24885036 Free PMC article.

Fragment C of tetanus toxin, more than a carrier. Novel perspectives in non-viral ALS gene therapy.
Moreno-Igoa M, Calvo AC, Penas C, Manzano R, Oliván S, Muñoz MJ, Mancuso R, Zaragoza P, Aguilera J, Navarro X, Osta Pinzolas R. J Mol Med (Berl). 2010 Mar;88(3):297-308. doi: 10.1007/s00109-009-0556-y. PMID: 19921501

Sigma receptor agonist 2-(4-morpholinethyl)1 phenylcyclohexanecarboxylate (Pre084) increases GDNF and BiP expression and promotes neuroprotection after root avulsion injury.
Penas C, Pascual-Font A, Mancuso R, Forés J, Casas C, Navarro X. J Neurotrauma. 2011 May;28(5):831-40. doi: 10.1089/neu.2010.1674. Epub 2011 Apr 12. PMID: 21332255

Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule.
Calvo AC, Moreno-Igoa M, Mancuso R, Manzano R, Oliván S, Muñoz MJ, Penas C, Zaragoza P, Navarro X, Osta R. Orphanet J Rare Dis. 2011 Mar 21;6:10. doi: 10.1186/1750-1172-6-10. PMID: 21418619 Free PMC article.

Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias.
Chételat G, Arbizu J, Barthel H, Garibotto V, Law I, Morbelli S, van de Giessen E, Agosta F, Barkhof F, Brooks DJ, Carrillo MC, Dubois B, Fjell AM, Frisoni GB, Hansson O, Herholz K, Hutton BF, Jack CR Jr, Lammertsma AA, Landau SM, Minoshima S, Nobili F, Nordberg A, Ossenkoppele R, Oyen WJG, Perani D, Rabinovici GD, Scheltens P, Villemagne VL, Zetterberg H, Drzezga A. Lancet Neurol. 2020 Nov;19(11):951-962. doi: 10.1016/S1474-4422(20)30314-8. PMID: 33098804 Review.

MRI of Motor and Nonmotor Therapy-Induced Complications in Parkinson's Disease.
Donzuso G, Agosta F, Canu E, Filippi M. Mov Disord. 2020 May;35(5):724-740. doi: 10.1002/mds.28025. Epub 2020 Mar 17. PMID: 32181946 Revie

Deep learning: a turning point in acute neurology.
Filippi M, Cividini C, Agosta F. Lancet Digit Health. 2020 Jun;2(6):e273-e274. doi: 10.1016/S2589-7500(20)30106-0. Epub 2020 May 14. PMID: 33328119 No abstract available

Functional brain connectome in posterior cortical atrophy.
Migliaccio R, Agosta F, Basaia S, Cividini C, Habert MO, Kas A, Montembeault M, Filippi M. Neuroimage Clin. 2020;25:102100. doi: 10.1016/j.nicl.2019.102100. Epub 2019 Nov 20. PMID: 31865020 Free PMC article

Focus on the heterogeneity of amyotrophic lateral sclerosis.
Bendotti C, Bonetto V, Pupillo E, Logroscino G, Al-Chalabi A, Lunetta C, Riva N, Mora G, Lauria G, Weishaupt JH, Agosta F, Malaspina A, Basso M, Greensmith L, Van Den Bosch L, Ratti A, Corbo M, Hardiman O, Chiò A, Silani V, Beghi E. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Nov;21(7-8):485-495. doi: 10.1080/21678421.2020.1779298. Epub 2020 Jun 25. PMID: 32583689

Amyloid-β-independent regulators of tau pathology in Alzheimer disease.
van der Kant R, Goldstein LSB, Ossenkoppele R. Nat Rev Neurosci. 2020 Jan;21(1):21-35. doi: 10.1038/s41583-019-0240-3. Epub 2019 Nov 28. PMID: 31780819 Review.

Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias.
Chételat G, Arbizu J, Barthel H, Garibotto V, Law I, Morbelli S, van de Giessen E, Agosta F, Barkhof F, Brooks DJ, Carrillo MC, Dubois B, Fjell AM, Frisoni GB, Hansson O, Herholz K, Hutton BF, Jack CR Jr, Lammertsma AA, Landau SM, Minoshima S, Nobili F, Nordberg A, Ossenkoppele R, Oyen WJG, Perani D, Rabinovici GD, Scheltens P, Villemagne VL, Zetterberg H, Drzezga A. Lancet Neurol. 2020 Nov;19(11):951-962. doi: 10.1016/S1474-4422(20)30314-8. PMID: 33098804 Review.

Clinicopathological correlations in behavioural variant frontotemporal dementia.
Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW. Brain. 2017 Dec 1;140(12):3329-3345. doi: 10.1093/brain/awx254. PMID: 29053860 Free PMC article.

The effect of physical activity on cognitive function in patients with dementia: A meta-analysis of randomized control trials.
Groot C, Hooghiemstra AM, Raijmakers PG, van Berckel BN, Scheltens P, Scherder EJ, van der Flier WM, Ossenkoppele R. Ageing Res Rev. 2016 Jan;25:13-23. doi: 10.1016/j.arr.2015.11.005. Epub 2015 Nov 28. PMID: 26607411 Review.

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
Jansen WJ, Ossenkoppele R, Knol DL, Tijms BM, Scheltens P, Verhey FR, Visser PJ; Amyloid Biomarker Study Group, Aalten P, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BN, Bibeau K, Blennow K, Brooks DJ, van Buchem MA, Camus V, Cavedo E, Chen K, Chetelat G, Cohen AD, Drzezga A, Engelborghs S, Fagan AM, Fladby T, Fleisher AS, van der Flier WM, Ford L, Förster S, Fortea J, Foskett N, Frederiksen KS, Freund-Levi Y, Frisoni GB, Froelich L, Gabryelewicz T, Gill KD, Gkatzima O, Gómez-Tortosa E, Gordon MF, Grimmer T, Hampel H, Hausner L, Hellwig S, Herukka SK, Hildebrandt H, Ishihara L, Ivanoiu A, Jagust WJ, Johannsen P, Kandimalla R, Kapaki E, Klimkowicz-Mrowiec A, Klunk WE, Köhler S, Koglin N, Kornhuber J, Kramberger MG, Van Laere K, Landau SM, Lee DY, de Leon M, Lisetti V, Lleó A, Madsen K, Maier W, Marcusson J, Mattsson N, de Mendonça A, Meulenbroek O, Meyer PT, Mintun MA, Mok V, Molinuevo JL, Møllergård HM, Morris JC, Mroczko B, Van der Mussele S, Na DL, Newberg A, Nordberg A, Nordlund A, Novak GP, Paraskevas GP, Parnetti L, Perera G, Peters O, Popp J, Prabhakar S, Rabinovici GD, Ramakers IH, Rami L, Resende de Oliveira C, Rinne JO, Rodrigue KM, Rodríguez-Rodríguez E, Roe CM, Rot U, Rowe CC, Rüther E, Sabri O, Sanchez-Juan P, Santana I, Sarazin M, Schröder J, Schütte C, Seo SW, Soetewey F, Soininen H, Spiru L, Struyfs H, Teunissen CE, Tsolaki M, Vandenberghe R, Verbeek MM, Villemagne VL, Vos SJ, van Waalwijk van Doorn LJ, Waldemar G, Wallin A, Wallin ÅK, Wiltfang J, Wolk DA, Zboch M, Zetterberg H. JAMA. 2015 May 19;313(19):1924-38. doi: 10.1001/jama.2015.4668. PMID: 25988462 Free PMC article.

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease.
Franzmeier N, Neitzel J, Rubinski A, Smith R, Strandberg O, Ossenkoppele R, Hansson O, Ewers M; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Nat Commun. 2020 Jan 17;11(1):347. doi: 10.1038/s41467-019-14159-1. PMID: 31953405 Free PMC article.

PET Imaging of Tau Deposition in the Aging Human Brain.
Schöll M, Lockhart SN, Schonhaut DR, O'Neil JP, Janabi M, Ossenkoppele R, Baker SL, Vogel JW, Faria J, Schwimmer HD, Rabinovici GD, Jagust WJ. Neuron. 2016 Mar 2;89(5):971-982. doi: 10.1016/j.neuron.2016.01.028. PMID: 26938442 Free PMC article.

The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features.
Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, La Joie R, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel BN, Miller BL, Barkhof F, Jagust WJ, Scheltens P, Seeley WW, Rabinovici GD. Brain. 2015 Sep;138(Pt 9):2732-49. doi: 10.1093/brain/awv191. Epub 2015 Jul 2. PMID: 26141491 Free PMC article.

Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship.
van Loenhoud AC, van der Flier WM, Wink AM, Dicks E, Groot C, Twisk J, Barkhof F, Scheltens P, Ossenkoppele R; Alzheimer's Disease Neuroimaging Initiative. Neurology. 2019 Jul 23;93(4):e334-e346. doi: 10.1212/WNL.0000000000007821. Epub 2019 Jul 2. PMID: 31266904 Free PMC article.

Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease.
Vogel JW, Iturria-Medina Y, Strandberg OT, Smith R, Levitis E, Evans AC, Hansson O; Alzheimer’s Disease Neuroimaging Initiative; Swedish BioFinder Study. Nat Commun. 2020 May 26;11(1):2612. doi: 10.1038/s41467-020-15701-2. PMID: 32457389 Free PMC article.

Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.
Bergeron D, Gorno-Tempini ML, Rabinovici GD, Santos-Santos MA, Seeley W, Miller BL, Pijnenburg Y, Keulen MA, Groot C, van Berckel BNM, van der Flier WM, Scheltens P, Rohrer JD, Warren JD, Schott JM, Fox NC, Sanchez-Valle R, Grau-Rivera O, Gelpi E, Seelaar H, Papma JM, van Swieten JC, Hodges JR, Leyton CE, Piguet O, Rogalski EJ, Mesulam MM, Koric L, Nora K, Pariente J, Dickerson B, Mackenzie IR, Hsiung GR, Belliard S, Irwin DJ, Wolk DA, Grossman M, Jones M, Harris J, Mann D, Snowden JS, Chrem-Mendez P, Calandri IL, Amengual AA, Miguet-Alfonsi C, Magnin E, Magnani G, Santangelo R, Deramecourt V, Pasquier F, Mattsson N, Nilsson C, Hansson O, Keith J, Masellis M, Black SE, Matías-Guiu JA, Cabrera-Martin MN, Paquet C, Dumurgier J, Teichmann M, Sarazin M, Bottlaender M, Dubois B, Rowe CC, Villemagne VL, Vandenberghe R, Granadillo E, Teng E, Mendez M, Meyer PT, Frings L, Lleó A, Blesa R, Fortea J, Seo SW, Diehl-Schmid J, Grimmer T, Frederiksen KS, Sánchez-Juan P, Chételat G, Jansen W, Bouchard RW, Laforce RJ, Visser PJ, Ossenkoppele R. Ann Neurol. 2018 Nov;84(5):729-740. doi: 10.1002/ana.25333. PMID: 30255971 Free PMC article.

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.
Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleó A, Mintun MA, Wallin A, Engelborghs S, Na DL, Chételat G, Molinuevo JL, Landau SM, Mattsson N, Kornhuber J, Sabri O, Rowe CC, Parnetti L, Popp J, Fladby T, Jagust WJ, Aalten P, Lee DY, Vandenberghe R, Resende de Oliveira C, Kapaki E, Froelich L, Ivanoiu A, Gabryelewicz T, Verbeek MM, Sanchez-Juan P, Hildebrandt H, Camus V, Zboch M, Brooks DJ, Drzezga A, Rinne JO, Newberg A, de Mendonça A, Sarazin M, Rabinovici GD, Madsen K, Kramberger MG, Nordberg A, Mok V, Mroczko B, Wolk DA, Meyer PT, Tsolaki M, Scheltens P, Verhey FRJ, Visser PJ; Amyloid Biomarker Study Group, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BNM, Blennow K, van Buchem MA, Cavedo E, Chen K, Chipi E, Cohen AD, Förster S, Fortea J, Frederiksen KS, Freund-Levi Y, Gkatzima O, Gordon MF, Grimmer T, Hampel H, Hausner L, Hellwig S, Herukka SK, Johannsen P, Klimkowicz-Mrowiec A, Köhler S, Koglin N, van Laere K, de Leon M, Lisetti V, Maier W, Marcusson J, Meulenbroek O, Møllergård HM, Morris JC, Nordlund A, Novak GP, Paraskevas GP, Perera G, Peters O, Ramakers IHGB, Rami L, Rodríguez-Rodríguez E, Roe CM, Rot U, Rüther E, Santana I, Schröder J, Seo SW, Soininen H, Spiru L, Stomrud E, Struyfs H, Teunissen CE, Vos SJB, van Waalwijk van Doorn LJC, Waldemar G, Wallin ÅK, Wiltfang J, Zetterberg H. JAMA Psychiatry. 2018 Jan 1;75(1):84-95. doi: 10.1001/jamapsychiatry.2017.3391. PMID: 29188296 Free PMC article.

Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease.
Ossenkoppele R, Lyoo CH, Sudre CH, van Westen D, Cho H, Ryu YH, Choi JY, Smith R, Strandberg O, Palmqvist S, Westman E, Tsai R, Kramer J, Boxer AL, Gorno-Tempini ML, La Joie R, Miller BL, Rabinovici GD, Hansson O. Alzheimers Dement. 2020 Feb;16(2):335-344. doi: 10.1016/j.jalz.2019.08.201. Epub 2020 Jan 4. PMID: 31672482 Free PMC article.

Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders.
Ossenkoppele R, Rabinovici GD, Smith R, Cho H, Schöll M, Strandberg O, Palmqvist S, Mattsson N, Janelidze S, Santillo A, Ohlsson T, Jögi J, Tsai R, La Joie R, Kramer J, Boxer AL, Gorno-Tempini ML, Miller BL, Choi JY, Ryu YH, Lyoo CH, Hansson O. JAMA. 2018 Sep 18;320(11):1151-1162. doi: 10.1001/jama.2018.12917. PMID: 30326496 Free PMC article.

Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer's disease.
Mattsson-Carlgren N, Andersson E, Janelidze S, Ossenkoppele R, Insel P, Strandberg O, Zetterberg H, Rosen HJ, Rabinovici G, Chai X, Blennow K, Dage JL, Stomrud E, Smith R, Palmqvist S, Hansson O. Sci Adv. 2020 Apr 15;6(16):eaaz2387. doi: 10.1126/sciadv.aaz2387. eCollection 2020 Apr. PMID: 32426454 Free PMC article.

Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease.
Berron D, van Westen D, Ossenkoppele R, Strandberg O, Hansson O. Brain. 2020 Apr 1;143(4):1233-1248. doi: 10.1093/brain/awaa068. PMID: 32252068 Free PMC article.

Applying the ATN scheme in a memory clinic population: The ABIDE project.
Altomare D, de Wilde A, Ossenkoppele R, Pelkmans W, Bouwman F, Groot C, van Maurik I, Zwan M, Yaqub M, Barkhof F, van Berckel BN, Teunissen CE, Frisoni GB, Scheltens P, van der Flier WM. Neurology. 2019 Oct 22;93(17):e1635-e1646. doi: 10.1212/WNL.0000000000008361. Epub 2019 Oct 9. PMID: 31597710

Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis.
Ossenkoppele R, Jansen WJ, Rabinovici GD, Knol DL, van der Flier WM, van Berckel BN, Scheltens P, Visser PJ; Amyloid PET Study Group, Verfaillie SC, Zwan MD, Adriaanse SM, Lammertsma AA, Barkhof F, Jagust WJ, Miller BL, Rosen HJ, Landau SM, Villemagne VL, Rowe CC, Lee DY, Na DL, Seo SW, Sarazin M, Roe CM, Sabri O, Barthel H, Koglin N, Hodges J, Leyton CE, Vandenberghe R, van Laere K, Drzezga A, Forster S, Grimmer T, Sánchez-Juan P, Carril JM, Mok V, Camus V, Klunk WE, Cohen AD, Meyer PT, Hellwig S, Newberg A, Frederiksen KS, Fleisher AS, Mintun MA, Wolk DA, Nordberg A, Rinne JO, Chételat G, Lleo A, Blesa R, Fortea J, Madsen K, Rodrigue KM, Brooks DJ. JAMA. 2015 May 19;313(19):1939-49. doi: 10.1001/jama.2015.4669. PMID: 25988463 Free PMC article.

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.
Ossenkoppele R, Schonhaut DR, Schöll M, Lockhart SN, Ayakta N, Baker SL, O'Neil JP, Janabi M, Lazaris A, Cantwell A, Vogel J, Santos M, Miller ZA, Bettcher BM, Vossel KA, Kramer JH, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD. Brain. 2016 May;139(Pt 5):1551-67. doi: 10.1093/brain/aww027. Epub 2016 Mar 8. PMID: 26962052 Free PMC article.

Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease.
Ossenkoppele R, Lyoo CH, Jester-Broms J, Sudre CH, Cho H, Ryu YH, Choi JY, Smith R, Strandberg O, Palmqvist S, Kramer J, Boxer AL, Gorno-Tempini ML, Miller BL, La Joie R, Rabinovici GD, Hansson O. JAMA Neurol. 2020 May 1;77(5):632-642. doi: 10.1001/jamaneurol.2019.5154. PMID: 32091549 Free PMC article.

Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders.
Leuzy A, Smith R, Ossenkoppele R, Santillo A, Borroni E, Klein G, Ohlsson T, Jögi J, Palmqvist S, Mattsson-Carlgren N, Strandberg O, Stomrud E, Hansson O. JAMA Neurol. 2020 Aug 1;77(8):955-965. doi: 10.1001/jamaneurol.2020.0989. PMID: 32391858 Free PMC article.

Mechanisms underlying resilience in ageing.
Stern Y, Chételat G, Habeck C, Arenaza-Urquijo EM, Vemuri P, Estanga A, Bartrés-Faz D, Cantillon M, Clouston SAP, Elman JA, Gold BT, Jones R, Kempermann G, Lim YY, van Loenhoud A, Martínez-Lage P, Morbelli S, Okonkwo O, Ossenkoppele R, Pettigrew C, Rosen AC, Scarmeas N, Soldan A, Udeh-Momoh C, Valenzuela M, Vuoksimaa E. Nat Rev Neurosci. 2019 Apr;20(4):246. doi: 10.1038/s41583-019-0138-0. PMID: 30814677 No abstract available.

Molecular imaging in dementia: Past, present, and future.
Laforce R Jr, Soucy JP, Sellami L, Dallaire-Théroux C, Brunet F, Bergeron D, Miller BL, Ossenkoppele R. Alzheimers Dement. 2018 Nov;14(11):1522-1552. doi: 10.1016/j.jalz.2018.06.2855. Epub 2018 Jul 18. PMID: 30028955 Review.

Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease.
Visser D, Wolters EE, Verfaillie SCJ, Coomans EM, Timmers T, Tuncel H, Reimand J, Boellaard R, Windhorst AD, Scheltens P, van der Flier WM, Ossenkoppele R, van Berckel BNM. Eur J Nucl Med Mol Imaging. 2020 Dec;47(13):3165-3175. doi: 10.1007/s00259-020-04831-w. Epub 2020 May 27. PMID: 32462397 Free PMC article.
Higher frontal BP(ND) was associated with worse executive function and attention. For [(18)F]flortaucipir R(1), lower values in the lateral temporal and parietal ROIs were associated with worse executive functioning, language and attention, and lower occipital R(1) …

Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease.
Franzmeier N, Dewenter A, Frontzkowski L, Dichgans M, Rubinski A, Neitzel J, Smith R, Strandberg O, Ossenkoppele R, Buerger K, Duering M, Hansson O, Ewers M. Sci Adv. 2020 Nov 27;6(48):eabd1327. doi: 10.1126/sciadv.abd1327. Print 2020 Nov. PMID: 33246962 Free PMC article.

Is intracranial volume a suitable proxy for brain reserve?
van Loenhoud AC, Groot C, Vogel JW, van der Flier WM, Ossenkoppele R. Alzheimers Res Ther. 2018 Sep 11;10(1):91. doi: 10.1186/s13195-018-0408-5. PMID: 30205838 Free PMC article. Review.

Tau PET and relative cerebral blood flow in dementia with Lewy bodies: A PET study.
Wolters EE, van de Beek M, Ossenkoppele R, Golla SSV, Verfaillie SCJ, Coomans EM, Timmers T, Visser D, Tuncel H, Barkhof F, Boellaard R, Windhorst AD, van der Flier WM, Scheltens P, Lemstra AW, van Berckel BNM. Neuroimage Clin. 2020;28:102504. doi: 10.1016/j.nicl.2020.102504. Epub 2020 Nov 19. PMID: 33395993 Free PMC article.
First, we performed regional comparisons of [(18)F]flortaucipir BP(ND) and R(1) between diagnostic groups. In DLB patients only, we performed regression analyses between regional [(18)F]flortaucipir BP(ND), R(1) and performance on ten neuropsychological tests. ...Lo …

Amyloid-β PET and CSF in an autopsy-confirmed cohort.
Reimand J, Boon BDC, Collij LE, Teunissen CE, Rozemuller AJM, van Berckel BNM, Scheltens P, Ossenkoppele R, Bouwman F. Ann Clin Transl Neurol. 2020 Nov;7(11):2150-2160. doi: 10.1002/acn3.51195. Epub 2020 Oct 20. PMID: 33080124 Free PMC article.

Discordant amyloid-β PET and CSF biomarkers and its clinical consequences.
de Wilde A, Reimand J, Teunissen CE, Zwan M, Windhorst AD, Boellaard R, van der Flier WM, Scheltens P, van Berckel BNM, Bouwman F, Ossenkoppele R. Alzheimers Res Ther. 2019 Sep 12;11(1):78. doi: 10.1186/s13195-019-0532-x. PMID: 31511058 Free PMC article.

Why Is Amyloid-β PET Requested After Performing CSF Biomarkers?
Reimand J, Groot C, Teunissen CE, Windhorst AD, Boellaard R, Barkhof F, Nazarenko S, van der Flier WM, van Berckel BNM, Scheltens P, Ossenkoppele R, Bouwman F. J Alzheimers Dis. 2020;73(2):559-569. doi: 10.3233/JAD-190836. PMID: 31796674 Free PMC article.

Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders.
Leuzy A, Smith R, Ossenkoppele R, Santillo A, Borroni E, Klein G, Ohlsson T, Jögi J, Palmqvist S, Mattsson-Carlgren N, Strandberg O, Stomrud E, Hansson O. JAMA Neurol. 2020 Aug 1;77(8):955-965. doi: 10.1001/jamaneurol.2020.0989. PMID: 32391858 Free PMC article.

Mechanisms underlying resilience in ageing.
Stern Y, Chételat G, Habeck C, Arenaza-Urquijo EM, Vemuri P, Estanga A, Bartrés-Faz D, Cantillon M, Clouston SAP, Elman JA, Gold BT, Jones R, Kempermann G, Lim YY, van Loenhoud A, Martínez-Lage P, Morbelli S, Okonkwo O, Ossenkoppele R, Pettigrew C, Rosen AC, Scarmeas N, Soldan A, Udeh-Momoh C, Valenzuela M, Vuoksimaa E. Nat Rev Neurosci. 2019 Apr;20(4):246. doi: 10.1038/s41583-019-0138-0. PMID: 30814677 No abstract available.

Molecular imaging in dementia: Past, present, and future.
Laforce R Jr, Soucy JP, Sellami L, Dallaire-Théroux C, Brunet F, Bergeron D, Miller BL, Ossenkoppele R. Alzheimers Dement. 2018 Nov;14(11):1522-1552. doi: 10.1016/j.jalz.2018.06.2855. Epub 2018 Jul 18. PMID: 30028955 Review.

Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease.
Visser D, Wolters EE, Verfaillie SCJ, Coomans EM, Timmers T, Tuncel H, Reimand J, Boellaard R, Windhorst AD, Scheltens P, van der Flier WM, Ossenkoppele R, van Berckel BNM. Eur J Nucl Med Mol Imaging. 2020 Dec;47(13):3165-3175. doi: 10.1007/s00259-020-04831-w. Epub 2020 May 27. PMID: 32462397 Free PMC article.
Higher frontal BP(ND) was associated with worse executive function and attention. For [(18)F]flortaucipir R(1), lower values in the lateral temporal and parietal ROIs were associated with worse executive functioning, language and attention, and lower occipital R(1) …

Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease.
Franzmeier N, Dewenter A, Frontzkowski L, Dichgans M, Rubinski A, Neitzel J, Smith R, Strandberg O, Ossenkoppele R, Buerger K, Duering M, Hansson O, Ewers M. Sci Adv. 2020 Nov 27;6(48):eabd1327. doi: 10.1126/sciadv.abd1327. Print 2020 Nov. PMID: 33246962 Free PMC article.

Is intracranial volume a suitable proxy for brain reserve?
van Loenhoud AC, Groot C, Vogel JW, van der Flier WM, Ossenkoppele R. Alzheimers Res Ther. 2018 Sep 11;10(1):91. doi: 10.1186/s13195-018-0408-5. PMID: 30205838 Free PMC article. Review.

Tau PET and relative cerebral blood flow in dementia with Lewy bodies: A PET study.
Wolters EE, van de Beek M, Ossenkoppele R, Golla SSV, Verfaillie SCJ, Coomans EM, Timmers T, Visser D, Tuncel H, Barkhof F, Boellaard R, Windhorst AD, van der Flier WM, Scheltens P, Lemstra AW, van Berckel BNM. Neuroimage Clin. 2020;28:102504. doi: 10.1016/j.nicl.2020.102504. Epub 2020 Nov 19. PMID: 33395993 Free PMC article.

Amyloid-β PET and CSF in an autopsy-confirmed cohort.
Reimand J, Boon BDC, Collij LE, Teunissen CE, Rozemuller AJM, van Berckel BNM, Scheltens P, Ossenkoppele R, Bouwman F. Ann Clin Transl Neurol. 2020 Nov;7(11):2150-2160. doi: 10.1002/acn3.51195. Epub 2020 Oct 20. PMID: 33080124 Free PMC article.

Discordant amyloid-β PET and CSF biomarkers and its clinical consequences.
de Wilde A, Reimand J, Teunissen CE, Zwan M, Windhorst AD, Boellaard R, van der Flier WM, Scheltens P, van Berckel BNM, Bouwman F, Ossenkoppele R. Alzheimers Res Ther. 2019 Sep 12;11(1):78. doi: 10.1186/s13195-019-0532-x. PMID: 31511058 Free PMC article.

Why Is Amyloid-β PET Requested After Performing CSF Biomarkers?
Reimand J, Groot C, Teunissen CE, Windhorst AD, Boellaard R, Barkhof F, Nazarenko S, van der Flier WM, van Berckel BNM, Scheltens P, Ossenkoppele R, Bouwman F. J Alzheimers Dis. 2020;73(2):559-569. doi: 10.3233/JAD-190836. PMID: 31796674 Free PMC article.

Predicting diagnosis and cognition with 18F-AV-1451 tau PET and structural MRI in Alzheimer's disease.
Mattsson N, Insel PS, Donohue M, Jögi J, Ossenkoppele R, Olsson T, Schöll M, Smith R, Hansson O. Alzheimers Dement. 2019 Apr;15(4):570-580. doi: 10.1016/j.jalz.2018.12.001. Epub 2019 Jan 25. PMID: 30639421

A clinical-radiological framework of the right temporal variant of frontotemporal dementia.
Ulugut Erkoyun H, Groot C, Heilbron R, Nelissen A, van Rossum J, Jutten R, Koene T, van der Flier WM, Wattjes MP, Scheltens P, Ossenkoppele R, Barkhof F, Pijnenburg Y. Brain. 2020 Sep 1;143(9):2831-2843. doi: 10.1093/brain/awaa225. PMID: 32830218

The Complexity of Subjective Cognitive Decline.
Ossenkoppele R, Jagust WJ. JAMA Neurol. 2017 Dec 1;74(12):1400-1402. doi: 10.1001/jamaneurol.2017.2224. PMID: 28973114 No abstract available.

Association of amyloid-β CSF/PET discordance and tau load 5 years later.
Reimand J, Collij L, Scheltens P, Bouwman F, Ossenkoppele R; Alzheimer's Disease Neuroimaging Initiative. Neurology. 2020 Nov 10;95(19):e2648-e2657. doi: 10.1212/WNL.0000000000010739. Epub 2020 Sep 10. PMID: 32913020

Association Between Earliest Amyloid Uptake and Functional Connectivity in Cognitively Unimpaired Elderly.

Hahn A, Strandberg TO, Stomrud E, Nilsson M, van Westen D, Palmqvist S, Ossenkoppele R, Hansson O. Cereb Cortex. 2019 May 1;29(5):2173-2182. doi: 10.1093/cercor/bhz020. PMID: 30877785 Free PMC article. Mainly certain parts of the default-mode network) was positively associated with dynamic but not static functional connectivity (r = 0.77). Dynamic functional connectivity was further related to better cognitive performance (r = 0.21-0.72). ...

Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease.
Ossenkoppele R, Smith R, Ohlsson T, Strandberg O, Mattsson N, Insel PS, Palmqvist S, Hansson O. Neurology. 2019 Feb 5;92(6):e601-e612. doi: 10.1212/WNL.0000000000006875. Epub 2019 Jan 9. PMID: 30626656 Free PMC article.

Amyloid and tau accumulate across distinct spatial networks and are differentially associated with brain connectivity.
Pereira JB, Ossenkoppele R, Palmqvist S, Strandberg TO, Smith R, Westman E, Hansson O. Elife. 2019 Dec 9;8:e50830. doi: 10.7554/eLife.50830. PMID: 31815669 Free PMC article.

Investigating the clinico-anatomical dissociation in the behavioral variant of Alzheimer disease.
Singleton EH, Pijnenburg YAL, Sudre CH, Groot C, Kochova E, Barkhof F, La Joie R, Rosen HJ, Seeley WW, Miller B, Cardoso MJ, Papma J, Scheltens P, Rabinovici GD, Ossenkoppele R. Alzheimers Res Ther. 2020 Nov 14;12(1):148. doi: 10.1186/s13195-020-00717-z. PMID: 33189136 Free PMC article.

Association between APOE ε2 and Aβ burden in patients with Alzheimer- and vascular-type cognitive impairment.
Lee JS, Lee H, Park S, Choe Y, Park YH, Cheon BK, Hahn A, Ossenkoppele R, Kim HJ, Kim S, Yoo H, Jang H, Cho SH, Kim SJ, Kim JP, Jung YH, Park KC, DeCarli C, Weiner MW, Na DL, Seo SW. Neurology. 2020 Oct 27;95(17):e2354-e2365. doi: 10.1212/WNL.0000000000010811. Epub 2020 Sep 14. PMID: 32928967

Prognostic value of Alzheimer's biomarkers in mild cognitive impairment: the effect of age at onset.
Altomare D, Ferrari C, Caroli A, Galluzzi S, Prestia A, van der Flier WM, Ossenkoppele R, Van Berckel B, Barkhof F, Teunissen CE, Wall A, Carter SF, Schöll M, Choo ILH, Grimmer T, Redolfi A, Nordberg A, Scheltens P, Drzezga A, Frisoni GB; Alzheimer’s Disease Neuroimaging Initiative. J Neurol. 2019 Oct;266(10):2535-2545. doi: 10.1007/s00415-019-09441-7. Epub 2019 Jul 2. PMID: 31267207

Associations between quantitative [18F]flortaucipir tau PET and atrophy across the Alzheimer's disease spectrum.
Timmers T, Ossenkoppele R, Wolters EE, Verfaillie SCJ, Visser D, Golla SSV, Barkhof F, Scheltens P, Boellaard R, van der Flier WM, van Berckel BNM. Alzheimers Res Ther. 2019 Jul 4;11(1):60. doi: 10.1186/s13195-019-0510-3. PMID: 31272512 Free PMC article.

Head-to-Head Comparison among Semi-Quantification Tools of Brain FDG-PET to Aid the Diagnosis of Prodromal Alzheimer's Disease.
Brugnolo A, De Carli F, Pagani M, Morbelli S, Jonsson C, Chincarini A, Frisoni GB, Galluzzi S, Perneczky R, Drzezga A, van Berckel BNM, Ossenkoppele R, Didic M, Guedj E, Arnaldi D, Massa F, Grazzini M, Pardini M, Mecocci P, Dottorini ME, Bauckneht M, Sambuceti G, Nobili F. J Alzheimers Dis. 2019;68(1):383-394. doi: 10.3233/JAD-181022. PMID: 30776000

The impact of demographic, clinical, genetic, and imaging variables on tau PET status.
Ossenkoppele R, Leuzy A, Cho H, Sudre CH, Strandberg O, Smith R, Palmqvist S, Mattsson-Carlgren N, Olsson T, Jögi J, Stormrud E, Ryu YH, Choi JY; Alzheimer’s Disease Neuroimaging Initiative; PREVENT-AD research group, Boxer AL, Gorno-Tempini ML, Miller BL, Soleimani-Meigooni D, Iaccarino L, La Joie R, Borroni E, Klein G, Pontecorvo MJ, Devous MD Sr, Villeneuve S, Lyoo CH, Rabinovici GD, Hansson O. Eur J Nucl Med Mol Imaging. 2020 Nov 19. doi: 10.1007/s00259-020-05099-w. Online ahead of print. PMID: 33215319

PET and CSF amyloid-β status are differently predicted by patient features: information from discordant cases.
Reimand J, de Wilde A, Teunissen CE, Zwan M, Windhorst AD, Boellaard R, Barkhof F, van der Flier WM, Scheltens P, van Berckel BNM, Ossenkoppele R, Bouwman F. Alzheimers Res Ther. 2019 Dec 7;11(1):100. doi: 10.1186/s13195-019-0561-5. PMID: 31810489 Free PMC article.

Combination of plasma amyloid beta(1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology.
Verberk IMW, Thijssen E, Koelewijn J, Mauroo K, Vanbrabant J, de Wilde A, Zwan MD, Verfaillie SCJ, Ossenkoppele R, Barkhof F, van Berckel BNM, Scheltens P, van der Flier WM, Stoops E, Vanderstichele HM, Teunissen CE. Alzheimers Res Ther. 2020 Sep 28;12(1):118. doi: 10.1186/s13195-020-00682-7. PMID: 32988409 Free PMC article.

Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β-negative cognitively normal individuals.
Groot C, Doré V, Robertson J, Burnham SC, Savage G, Ossenkoppele R, Rowe CC, Villemagne VL. Neurobiol Aging. 2021 Jan;97:41-48. doi: 10.1016/j.neurobiolaging.2020.09.017. Epub 2020 Oct 1. PMID: 33130455

High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study.
van Loenhoud AC, de Boer C, Wols K, Pijnenburg YA, Lemstra AW, Bouwman FH, Prins ND, Scheltens P, Ossenkoppele R, van der Flier WM. Alzheimers Res Ther. 2019 Dec 27;11(1):112. doi: 10.1186/s13195-019-0570-4. PMID: 31882022 Free PMC article.

Data-driven approaches for tau-PET imaging biomarkers in Alzheimer's disease.
Vogel JW, Mattsson N, Iturria-Medina Y, Strandberg OT, Schöll M, Dansereau C, Villeneuve S, van der Flier WM, Scheltens P, Bellec P, Evans AC, Hansson O, Ossenkoppele R; Alzheimer's Disease Neuroimaging Initiative; Swedish BioFINDER Study. Hum Brain Mapp. 2019 Feb 1;40(2):638-651. doi: 10.1002/hbm.24401. Epub 2018 Oct 19. PMID: 30368979 Free PMC article.

Derivation and utility of an Aβ-PET pathology accumulation index to estimate Aβ load.
Leuzy A, Lilja J, Buckley CJ, Ossenkoppele R, Palmqvist S, Battle M, Farrar G, Thal DR, Janelidze S, Stomrud E, Strandberg O, Smith R, Hansson O. Neurology. 2020 Nov 24;95(21):e2834-e2844. doi: 10.1212/WNL.0000000000011031. Epub 2020 Oct 19. PMID: 33077542 Free PMC article.
RESULTS: Strong associations were observed between Abeta index and SUVR (R (2): BioFINDER 0.951, ADNI 0.943, end-of-life, 0.916). Both measures performed equally well in differentiating Abeta-positive from Abeta-negative participants, with areas under the curve (AUCs) of 0 …

Evidence-based Interpretation of Amyloid-β PET Results: A Clinician's Tool.
Bergeron D, Ossenkoppele R, Jr Laforce R. Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):28-34. doi: 10.1097/WAD.0000000000000239. PMID: 29334498

Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain.
Ossenkoppele R, Iaccarino L, Schonhaut DR, Brown JA, La Joie R, O'Neil JP, Janabi M, Baker SL, Kramer JH, Gorno-Tempini ML, Miller BL, Rosen HJ, Seeley WW, Jagust WJ, Rabinovici GD. Neuroimage Clin. 2019;23:101848. doi: 10.1016/j.nicl.2019.101848. Epub 2019 May 2. PMID: 31077982 Free PMC article.

Correction to: Regional [18F]flortaucipir PET is more closely associated with disease severity than CSF p-tau in Alzheimer's disease.
Wolters EE, Ossenkoppele R, Verfaillie SCJ, Coomans EM, Timmers T, Visser D, Tuncel H, Golla SSV, Windhorst AD, Boellaard R, van der Flier WM, Teunissen CE, Scheltens P, van Berckel BNM. Eur J Nucl Med Mol Imaging. 2020 Nov;47(12):2934-2935. doi: 10.1007/s00259-020-04849-0. PMID: 32388611 Free PMC article.

The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects.
Smith R, Strandberg O, Mattsson-Carlgren N, Leuzy A, Palmqvist S, Pontecorvo MJ, Devous MD, Ossenkoppele R, Hansson O. Brain. 2020 Dec 1;143(12):3805-3815. doi: 10.1093/brain/awaa327. PMID: 33439987 Free PMC article.

[Amyloid PET imaging in patients with Alzheimer's disease].
Scheltens P, Zwan M, Ossenkoppele R, Bouwman F, van Berckel BN. Ned Tijdschr Geneeskd. 2017;161:D808. PMID: 28145213 Dutch.

Hippocampal [18F]flortaucipir BPND corrected for possible spill-in of the choroid plexus retains strong clinico-pathological relationships.
Wolters EE, Ossenkoppele R, Golla SS, Verfaillie SC, Timmers T, Visser D, Tuncel H, Coomans EM, Windhorst AD, Scheltens P, van der Flier WM, Boellaard R, van Berckel BN. Neuroimage Clin. 2020;25:102113. doi: 10.1016/j.nicl.2019.102113. Epub 2019 Dec 2. PMID: 31835238 Free PMC article.

Regional [18F]flortaucipir PET is more closely associated with disease severity than CSF p-tau in Alzheimer's disease.
Wolters EE, Ossenkoppele R, Verfaillie SCJ, Coomans EM, Timmers T, Visser D, Tuncel H, Golla SSV, Windhorst AD, Boellaard R, van der Flier WM, Teunissen CE, Scheltens P, van Berckel BNM. Eur J Nucl Med Mol Imaging. 2020 Nov;47(12):2866-2878. doi: 10.1007/s00259-020-04758-2. Epub 2020 Apr 14. PMID: 32291510 Free PMC article.

Assessment of the appropriate use criteria for amyloid PET in an unselected memory clinic cohort: The ABIDE project.
de Wilde A, Ossenkoppele R, Pelkmans W, Bouwman F, Groot C, van Maurik I, Zwan M, Yaqub M, Barkhof F, Lammertsma AA, Biessels GJ, Scheltens P, van Berckel BN, van der Flier WM. Alzheimers Dement. 2019 Nov;15(11):1458-1467. doi: 10.1016/j.jalz.2019.07.003. Epub 2019 Oct 6. PMID: 31594684 Free article.

Amyloid-β Load Is Related to Worries, but Not to Severity of Cognitive Complaints in Individuals With Subjective Cognitive Decline: The SCIENCe Project.
Verfaillie SCJ, Timmers T, Slot RER, van der Weijden CWJ, Wesselman LMP, Prins ND, Sikkes SAM, Yaqub M, Dols A, Lammertsma AA, Scheltens P, Ossenkoppele R, van Berckel BNM, van der Flier WM. Front Aging Neurosci. 2019 Jan 25;11:7. doi: 10.3389/fnagi.2019.00007. eCollection 2019. PMID: 30760996 Free PMC article.

Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer's disease: protocol of the BEAT-IT study.
Eikelboom WS, Singleton E, van den Berg E, Coesmans M, Mattace Raso F, van Bruchem RL, Goudzwaard JA, de Jong FJ, Koopmanschap M, den Heijer T, Driesen JJM, Vroegindeweij LJHM, Thomeer EC, Hoogers SE, Dijkstra AA, Zuidema SU, Pijnenburg YAL, Scheltens P, van Swieten JC, Ossenkoppele R, Papma JM. Alzheimers Res Ther. 2019 May 24;11(1):48. doi: 10.1186/s13195-019-0503-2. PMID: 31122267 Free PMC article. Clinical Trial.

Quantification of Tau Load Using [18F]AV1451 PET.
Golla SSV, Timmers T, Ossenkoppele R, Groot C, Verfaillie S, Scheltens P, van der Flier WM, Schwarte L, Mintun MA, Devous M, Schuit RC, Windhorst AD, Lammertsma AA, Boellaard R, van Berckel BNM, Yaqub M. Mol Imaging Biol. 2017 Dec;19(6):963-971. doi: 10.1007/s11307-017-1080-z. PMID: 28374171 Free PMC article.

Amyloid imaging in prodromal Alzheimer's disease.
Ossenkoppele R, van Berckel BN, Prins ND. Alzheimers Res Ther. 2011 Sep 19;3(5):26. doi: 10.1186/alzrt88. PMID: 21936965 Free PMC article.

Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease.
Scheltens NME, van der Weijden K, Adriaanse SM, van Assema D, Oomen PP, Krudop WA, Lammertsma AA, Barkhof F, Koene T, Teunissen CE, Scheltens P, van der Flier WM, Pijnenburg YAL, Yaqub M, Ossenkoppele R, van Berckel BNM. Neuroimage Clin. 2018 May 22;19:625-632. doi: 10.1016/j.nicl.2018.05.024. eCollection 2018. PMID: 29984170 Free PMC article.

Clinical phenotype, atrophy, and small vessel disease in APOEε2 carriers with Alzheimer disease.
Groot C, Sudre CH, Barkhof F, Teunissen CE, van Berckel BNM, Seo SW, Ourselin S, Scheltens P, Cardoso MJ, van der Flier WM, Ossenkoppele R. Neurology. 2018 Nov 13;91(20):e1851-e1859. doi: 10.1212/WNL.0000000000006503. Epub 2018 Oct 19. PMID: 30341156

Amyloid imaging in clinical trials.
Ossenkoppele R, Prins ND, van Berckel BN. Alzheimers Res Ther. 2013 Aug 14;5(4):36. doi: 10.1186/alzrt195. eCollection 2013. PMID: 23953396 Free PMC article.

Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar?
Fredericks CA, Brown JA, Deng J, Kramer A, Ossenkoppele R, Rankin K, Kramer JH, Miller BL, Rabinovici GD, Seeley WW. Neuroimage Clin. 2019;21:101628. doi: 10.1016/j.nicl.2018.101628. Epub 2018 Dec 3. PMID: 30528957 Free PMC article.

Quantification of Tau Load in Alzheimer's Disease Clinical Trials Using Positron Emission Tomography.
Timmers T, van Berckel BNM, Lammertsma AA, Ossenkoppele R. Methods Mol Biol. 2018;1750:221-229. doi: 10.1007/978-1-4939-7704-8_15. PMID: 29512076

Amyloid Pathology, Cognitive Impairment, and Alzheimer Disease Risk--Reply.
Jansen WJ, Ossenkoppele R, Visser PJ. JAMA. 2015 Sep 15;314(11):1177-8. doi: 10.1001/jama.2015.9719. PMID: 26372591 No abstract available.

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.
Mattsson N, Groot C, Jansen WJ, Landau SM, Villemagne VL, Engelborghs S, Mintun MM, Lleo A, Molinuevo JL, Jagust WJ, Frisoni GB, Ivanoiu A, Chételat G, Resende de Oliveira C, Rodrigue KM, Kornhuber J, Wallin A, Klimkowicz-Mrowiec A, Kandimalla R, Popp J, Aalten PP, Aarsland D, Alcolea D, Almdahl IS, Baldeiras I, van Buchem MA, Cavedo E, Chen K, Cohen AD, Förster S, Fortea J, Frederiksen KS, Freund-Levi Y, Gill KD, Gkatzima O, Grimmer T, Hampel H, Herukka SK, Johannsen P, van Laere K, de Leon MJ, Maier W, Marcusson J, Meulenbroek O, Møllergård HM, Morris JC, Mroczko B, Nordlund A, Prabhakar S, Peters O, Rami L, Rodríguez-Rodríguez E, Roe CM, Rüther E, Santana I, Schröder J, Seo SW, Soininen H, Spiru L, Stomrud E, Struyfs H, Teunissen CE, Verhey FRJ, Vos SJB, van Waalwijk van Doorn LJC, Waldemar G, Wallin ÅK, Wiltfang J, Vandenberghe R, Brooks DJ, Fladby T, Rowe CC, Drzezga A, Verbeek MM, Sarazin M, Wolk DA, Fleisher AS, Klunk WE, Na DL, Sánchez-Juan P, Lee DY, Nordberg A, Tsolaki M, Camus V, Rinne JO, Fagan AM, Zetterberg H, Blennow K, Rabinovici GD, Hansson O, van Berckel BNM, van der Flier WM, Scheltens P, Visser PJ, Ossenkoppele R. Alzheimers Dement. 2018 Jul;14(7):913-924. doi: 10.1016/j.jalz.2018.02.009. Epub 2018 Mar 28. PMID: 29601787

Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer's disease: a cohort study.
Mattsson N, Ossenkoppele R, Smith R, Strandberg O, Ohlsson T, Jögi J, Palmqvist S, Stomrud E, Hansson O. Alzheimers Res Ther. 2018 Aug 7;10(1):77. doi: 10.1186/s13195-018-0403-x. PMID: 30086796 Free PMC article.

Neuropsychiatric Symptoms Complicating the Diagnosis of Alzheimer's Disease: A Case Report.
Eikelboom WS, van Rooij JGJ, van den Berg E, Coesmans M, Jiskoot LC, Singleton E, Ossenkoppele R, van Swieten JC, Seelaar H, Papma JM. J Alzheimers Dis. 2018;66(4):1363-1369. doi: 10.3233/JAD-180700. PMID: 30412494

 

A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus.
Wolters EE, Golla SSV, Timmers T, Ossenkoppele R, van der Weijden CWJ, Scheltens P, Schwarte L, Schuit RC, Windhorst AD, Barkhof F, Yaqub M, Lammertsma AA, Boellaard R, van Berckel BNM. EJNMMI Res. 2018 Aug 15;8(1):79. doi: 10.1186/s13550-018-0432-2. PMID: 30112620 Free PMC article.
RESULTS: For controls, the correlation between hippocampal and CP V(T) was significantly reduced after using PVC along with an eroded VOI (r(2) = 0.59, slope = 0.80 versus r(2) = 0.15, slope = 0.15; difference: p < 0.05). ...

Differential effects of cognitive reserve and brain reserve on cognition in Alzheimer disease.
Groot C, van Loenhoud AC, Barkhof F, van Berckel BNM, Koene T, Teunissen CC, Scheltens P, van der Flier WM, Ossenkoppele R. Neurology. 2018 Jan 9;90(2):e149-e156. doi: 10.1212/WNL.0000000000004802. Epub 2017 Dec 13. PMID: 29237798

Quantitative PET and Histology of Brain Biopsy Reveal Lack of Selective Pittsburgh Compound-B Binding to Intracerebral Amyloidoma.
Groot C, Tolboom N, Ikonomovic MD, Lammertsma AA, Boon BDC, Barkhof F, Scheltens P, Klunk WE, Rozemuller AJM, Ossenkoppele R, van Berckel BNM. J Alzheimers Dis. 2018;65(1):71-77. doi: 10.3233/JAD-180316. PMID: 30040724

Association of Amyloid Positron Emission Tomography With Changes in Diagnosis and Patient Treatment in an Unselected Memory Clinic Cohort: The ABIDE Project.
de Wilde A, van der Flier WM, Pelkmans W, Bouwman F, Verwer J, Groot C, van Buchem MM, Zwan M, Ossenkoppele R, Yaqub M, Kunneman M, Smets EMA, Barkhof F, Lammertsma AA, Stephens A, van Lier E, Biessels GJ, van Berckel BN, Scheltens P. JAMA Neurol. 2018 Sep 1;75(9):1062-1070. doi: 10.1001/jamaneurol.2018.1346. PMID: 29889941 Free PMC article.

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease.
Iaccarino L, Tammewar G, Ayakta N, Baker SL, Bejanin A, Boxer AL, Gorno-Tempini ML, Janabi M, Kramer JH, Lazaris A, Lockhart SN, Miller BL, Miller ZA, O'Neil JP, Ossenkoppele R, Rosen HJ, Schonhaut DR, Jagust WJ, Rabinovici GD. Neuroimage Clin. 2017 Sep 25;17:452-464. doi: 10.1016/j.nicl.2017.09.016. eCollection 2018. PMID: 29159058 Free PMC article.

Distinct 18F-AV-1451 tau PET retention patterns in early- and late-onset Alzheimer's disease.
Schöll M, Ossenkoppele R, Strandberg O, Palmqvist S; Swedish BioFINDER study, Jögi J, Ohlsson T, Smith R, Hansson O. Brain. 2017 Sep 1;140(9):2286-2294. doi: 10.1093/brain/awx171. PMID: 29050382

A neuroimaging approach to capture cognitive reserve: Application to Alzheimer's disease.
van Loenhoud AC, Wink AM, Groot C, Verfaillie SCJ, Twisk J, Barkhof F, van Berckel B, Scheltens P, van der Flier WM, Ossenkoppele R. Hum Brain Mapp. 2017 Sep;38(9):4703-4715. doi: 10.1002/hbm.23695. Epub 2017 Jun 20. PMID: 28631336 Free PMC article. To validate this method, we showed that education correlated with mean W-scores in whole-brain (r = -0.090, P < 0.05) and temporoparietal (r = -0.122, P < 0.01) masks, indicating that higher education was associated with more CR (i.e. greater atrophy than pred

The Association of Glucose Metabolism and Eigenvector Centrality in Alzheimer's Disease.
Adriaanse SM, Wink AM, Tijms BM, Ossenkoppele R, Verfaillie SC, Lammertsma AA, Boellaard R, Scheltens P, van Berckel BN, Barkhof F. Brain Connect. 2016 Feb;6(1):1-8. doi: 10.1089/brain.2014.0320. Epub 2015 Nov 10. PMID: 26414628

Arterial spin labeling-based Z-maps have high specificity and positive predictive value for neurodegenerative dementia compared to FDG-PET.
Fällmar D, Haller S, Lilja J, Danfors T, Kilander L, Tolboom N, Egger K, Kellner E, Croon PM, Verfaillie SCJ, van Berckel BNM, Ossenkoppele R, Barkhof F, Larsson EM. Eur Radiol. 2017 Oct;27(10):4237-4246. doi: 10.1007/s00330-017-4784-1. Epub 2017 Apr 3. PMID: 28374078 Free PMC article.

Untangling the association of amyloid-β and tau with synaptic and axonal loss in Alzheimer's disease.
Pereira JB, Janelidze S, Ossenkoppele R, Kvartsberg H, Brinkmalm A, Mattsson-Carlgren N, Stomrud E, Smith R, Zetterberg H, Blennow K, Hansson O. Brain. 2021 Feb 12;144(1):310-324. doi: 10.1093/brain/awaa395. PMID: 33279949

Atrophy, hypometabolism and clinical trajectories in patients with amyloid-negative Alzheimer's disease.
Chételat G, Ossenkoppele R, Villemagne VL, Perrotin A, Landeau B, Mézenge F, Jagust WJ, Dore V, Miller BL, Egret S, Seeley WW, van der Flier WM, La Joie R, Ames D, van Berckel BN, Scheltens P, Barkhof F, Rowe CC, Masters CL, de La Sayette V, Bouwman F, Rabinovici GD. Brain. 2016 Sep;139(Pt 9):2528-39. doi: 10.1093/brain/aww159. Epub 2016 Jun 29. PMID: 27357349 Free PMC article.

Longitudinal amyloid imaging using 11C-PiB: methodologic considerations.
van Berckel BN, Ossenkoppele R, Tolboom N, Yaqub M, Foster-Dingley JC, Windhorst AD, Scheltens P, Lammertsma AA, Boellaard R. J Nucl Med. 2013 Sep;54(9):1570-6. doi: 10.2967/jnumed.112.113654. Epub 2013 Aug 12. PMID: 23940304 Free article.

Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease.
Ossenkoppele R, Cohn-Sheehy BI, La Joie R, Vogel JW, Möller C, Lehmann M, van Berckel BN, Seeley WW, Pijnenburg YA, Gorno-Tempini ML, Kramer JH, Barkhof F, Rosen HJ, van der Flier WM, Jagust WJ, Miller BL, Scheltens P, Rabinovici GD. Hum Brain Mapp. 2015 Nov;36(11):4421-37. doi: 10.1002/hbm.22927. Epub 2015 Aug 11. PMID: 26260856 Free PMC article.

Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions.
Ossenkoppele R, van der Flier WM, Verfaillie SC, Vrenken H, Versteeg A, van Schijndel RA, Sikkes SA, Twisk J, Adriaanse SM, Zwan MD, Boellaard R, Windhorst AD, Barkhof F, Scheltens P, Lammertsma AA, van Berckel BN. Neurology. 2014 May 20;82(20):1768-75. doi: 10.1212/WNL.0000000000000432. Epub 2014 Apr 18. PMID: 24748672

Concordance between cerebrospinal fluid biomarkers and [11C]PIB PET in a memory clinic cohort.
Zwan M, van Harten A, Ossenkoppele R, Bouwman F, Teunissen C, Adriaanse S, Lammertsma A, Scheltens P, van Berckel B, van der Flier W. J Alzheimers Dis. 2014;41(3):801-7. doi: 10.3233/JAD-132561. PMID: 24705549

Frontotemporal dementia with the V337M MAPT mutation: Tau-PET and pathology correlations.
Spina S, Schonhaut DR, Boeve BF, Seeley WW, Ossenkoppele R, O'Neil JP, Lazaris A, Rosen HJ, Boxer AL, Perry DC, Miller BL, Dickson DW, Parisi JE, Jagust WJ, Murray ME, Rabinovici GD. Neurology. 2017 Feb 21;88(8):758-766. doi: 10.1212/WNL.0000000000003636. Epub 2017 Jan 27. PMID: 28130473 Free PMC article.

Widespread disruption of functional brain organization in early-onset Alzheimer's disease.
Adriaanse SM, Binnewijzend MA, Ossenkoppele R, Tijms BM, van der Flier WM, Koene T, Smits LL, Wink AM, Scheltens P, van Berckel BN, Barkhof F. PLoS One. 2014 Jul 31;9(7):e102995. doi: 10.1371/journal.pone.0102995. eCollection 2014. PMID: 25080229 Free PMC article.

Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer's Disease.
Verfaillie SCJ, Pichet Binette A, Vachon-Presseau E, Tabrizi S, Savard M, Bellec P, Ossenkoppele R, Scheltens P, van der Flier WM, Breitner JCS, Villeneuve S; PREVENT-AD Research Group. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 May;3(5):463-472. doi: 10.1016/j.bpsc.2017.11.012. Epub 2017 Dec 14. PMID: 29735156

Spatial Relationships between Molecular Pathology and Neurodegeneration in the Alzheimer's Disease Continuum.
Iaccarino L, La Joie R, Edwards L, Strom A, Schonhaut DR, Ossenkoppele R, Pham J, Mellinger T, Janabi M, Baker SL, Soleimani-Meigooni D, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD. Cereb Cortex. 2021 Jan 1;31(1):1-14. doi: 10.1093/cercor/bhaa184. PMID: 32808011

Time to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease.
Insel PS, Ossenkoppele R, Gessert D, Jagust W, Landau S, Hansson O, Weiner MW, Mattsson N; Alzheimer's Disease Neuroimaging Initiative. Front Neurosci. 2017 May 17;11:281. doi: 10.3389/fnins.2017.00281. eCollection 2017. PMID: 28567001 Free PMC article.

Visual versus semi-quantitative analysis of 18F-FDG-PET in amnestic MCI: an European Alzheimer's Disease Consortium (EADC) project.
Morbelli S, Brugnolo A, Bossert I, Buschiazzo A, Frisoni GB, Galluzzi S, van Berckel BN, Ossenkoppele R, Perneczky R, Drzezga A, Didic M, Guedj E, Sambuceti G, Bottoni G, Arnaldi D, Picco A, De Carli F, Pagani M, Nobili F. J Alzheimers Dis. 2015;44(3):815-26. doi: 10.3233/JAD-142229. PMID: 25362041

Mild cognitive impairment with suspected nonamyloid pathology (SNAP): Prediction of progression.
Caroli A, Prestia A, Galluzzi S, Ferrari C, van der Flier WM, Ossenkoppele R, Van Berckel B, Barkhof F, Teunissen C, Wall AE, Carter SF, Schöll M, Choo IH, Grimmer T, Redolfi A, Nordberg A, Scheltens P, Drzezga A, Frisoni GB; Alzheimer's Disease Neuroimaging Initiative. Neurology. 2015 Feb 3;84(5):508-15. doi: 10.1212/WNL.0000000000001209. Epub 2015 Jan 7. PMID: 25568301 Free PMC article.

Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy.
Ossenkoppele R, Schonhaut DR, Baker SL, O'Neil JP, Janabi M, Ghosh PM, Santos M, Miller ZA, Bettcher BM, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD. Ann Neurol. 2015 Feb;77(2):338-42. doi: 10.1002/ana.24321. Epub 2014 Dec 17. PMID: 25448043 Free PMC article.

Comparison of simplified parametric methods for visual interpretation of 11C-Pittsburgh compound-B PET images.
Zwan MD, Ossenkoppele R, Tolboom N, Beunders AJ, Kloet RW, Adriaanse SM, Boellaard R, Windhorst AD, Raijmakers P, Adams H, Lammertsma AA, Scheltens P, van der Flier WM, van Berckel BN. J Nucl Med. 2014 Aug;55(8):1305-7. doi: 10.2967/jnumed.114.139121. Epub 2014 Jun 4. PMID: 24898026

Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease.
Prestia A, Caroli A, van der Flier WM, Ossenkoppele R, Van Berckel B, Barkhof F, Teunissen CE, Wall AE, Carter SF, Schöll M, Choo IH, Nordberg A, Scheltens P, Frisoni GB. Neurology. 2013 Mar 12;80(11):1048-56. doi: 10.1212/WNL.0b013e3182872830. Epub 2013 Feb 6. PMID: 23390179

The effect of amyloid pathology and glucose metabolism on cortical volume loss over time in Alzheimer's disease.
Adriaanse SM, van Dijk KR, Ossenkoppele R, Reuter M, Tolboom N, Zwan MD, Yaqub M, Boellaard R, Windhorst AD, van der Flier WM, Scheltens P, Lammertsma AA, Barkhof F, van Berckel BN. Eur J Nucl Med Mol Imaging. 2014 Jun;41(6):1190-8. doi: 10.1007/s00259-014-2704-z. Epub 2014 Mar 11. PMID: 24615466 Free PMC article.

Is verbal episodic memory in elderly with amyloid deposits preserved through altered neuronal function?
Ossenkoppele R, Madison C, Oh H, Wirth M, van Berckel BN, Jagust WJ. Cereb Cortex. 2014 Aug;24(8):2210-8. doi: 10.1093/cercor/bht076. Epub 2013 Mar 28. PMID: 23537530 Free PMC article.

Amyloid and its association with default network integrity in Alzheimer's disease.
Adriaanse SM, Sanz-Arigita EJ, Binnewijzend MA, Ossenkoppele R, Tolboom N, van Assema DM, Wink AM, Boellaard R, Yaqub M, Windhorst AD, van der Flier WM, Scheltens P, Lammertsma AA, Rombouts SA, Barkhof F, van Berckel BN. Hum Brain Mapp. 2014 Mar;35(3):779-91. doi: 10.1002/hbm.22213. Epub 2012 Dec 14. PMID: 23238869 Free PMC article.

Application of Machine Learning to Arterial Spin Labeling in Mild Cognitive Impairment and Alzheimer Disease.
Collij LE, Heeman F, Kuijer JP, Ossenkoppele R, Benedictus MR, Möller C, Verfaillie SC, Sanz-Arigita EJ, van Berckel BN, van der Flier WM, Scheltens P, Barkhof F, Wink AM. Radiology. 2016 Dec;281(3):865-875. doi: 10.1148/radiol.2016152703. Epub 2016 Jul 6. PMID: 27383395 Clinical Trial.

 

Cerebral perfusion and glucose metabolism in Alzheimer's disease and frontotemporal dementia: two sides of the same coin?
Verfaillie SC, Adriaanse SM, Binnewijzend MA, Benedictus MR, Ossenkoppele R, Wattjes MP, Pijnenburg YA, van der Flier WM, Lammertsma AA, Kuijer JP, Boellaard R, Scheltens P, van Berckel BN, Barkhof F. Eur Radiol. 2015 Oct;25(10):3050-9. doi: 10.1007/s00330-015-3696-1. Epub 2015 Apr 22. PMID: 25899416 Free PMC article.

Prediction of AD dementia by biomarkers following the NIA-AA and IWG diagnostic criteria in MCI patients from three European memory clinics.
Prestia A, Caroli A, Wade SK, van der Flier WM, Ossenkoppele R, Van Berckel B, Barkhof F, Teunissen CE, Wall A, Carter SF, Schöll M, Choo IH, Nordberg A, Scheltens P, Frisoni GB. Alzheimers Dement. 2015 Oct;11(10):1191-201. doi: 10.1016/j.jalz.2014.12.001. Epub 2015 Jan 31. PMID: 25646957

Comparing ATN-T designation by tau PET visual reads, tau PET quantification, and CSF PTau181 across three cohorts.
Provost K, Iaccarino L, Soleimani-Meigooni DN, Baker S, Edwards L, Eichenlaub U, Hansson O, Jagust W, Janabi M, La Joie R, Lesman-Segev O, Mellinger TJ, Miller BL, Ossenkoppele R, Pham J, Smith R, Sonni I, Strom A, Mattsson-Carlgren N, Rabinovici GD; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Eur J Nucl Med Mol Imaging. 2021 Jan 4. doi: 10.1007/s00259-020-05152-8. Online ahead of print. PMID: 33398408

Non-invasive Standardised Uptake Value for Verification of the Use of Previously Validated Reference Region for [18F]Flortaucipir and [18F]Florbetapir Brain PET Studies.
de Vries BM, Timmers T, Wolters EE, Ossenkoppele R, Verfaillie SCJ, Schuit RC, Scheltens P, van der Flier WM, Windhorst AD, van Berckel BNM, Boellaard R, Golla SSV. Mol Imaging Biol. 2021 Jan 14. doi: 10.1007/s11307-020-01572-y. Online ahead of print. PMID: 33443720

Impact of molecular imaging on the diagnostic process in a memory clinic.
Ossenkoppele R, Prins ND, Pijnenburg YA, Lemstra AW, van der Flier WM, Adriaanse SF, Windhorst AD, Handels RL, Wolfs CA, Aalten P, Verhey FR, Verbeek MM, van Buchem MA, Hoekstra OS, Lammertsma AA, Scheltens P, van Berckel BN. Alzheimers Dement. 2013 Jul;9(4):414-21. doi: 10.1016/j.jalz.2012.07.003. Epub 2012 Nov 16. PMID: 23164552 Clinical Trial.

Clinical validity of increased cortical uptake of [18F]flortaucipir on PET as a biomarker for Alzheimer's disease in the context of a structured 5-phase biomarker development framework.
Wolters EE, Dodich A, Boccardi M, Corre J, Drzezga A, Hansson O, Nordberg A, Frisoni GB, Garibotto V, Ossenkoppele R. Eur J Nucl Med Mol Imaging. 2021 Feb 6. doi: 10.1007/s00259-020-05118-w. Online ahead of print. PMID: 33547556 Review.

Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET.
Ossenkoppele R, Tolboom N, Foster-Dingley JC, Adriaanse SF, Boellaard R, Yaqub M, Windhorst AD, Barkhof F, Lammertsma AA, Scheltens P, van der Flier WM, van Berckel BN. Eur J Nucl Med Mol Imaging. 2012 Jun;39(6):990-1000. doi: 10.1007/s00259-012-2102-3. Epub 2012 Mar 23. PMID: 22441582 Clinical Trial.

Clinical validity of second-generation tau PET tracers as biomarkers for Alzheimer's disease in the context of a structured 5-phase development framework.
Bischof GN, Dodich A, Boccardi M, van Eimeren T, Festari C, Barthel H, Hansson O, Nordberg A, Ossenkoppele R, Sabri O, Giovanni BFG, Garibotto V, Drzezga A. Eur J Nucl Med Mol Imaging. 2021 Feb 16. doi: 10.1007/s00259-020-05156-4. Online ahead of print. PMID: 33590274 Review.

Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia.
Ossenkoppele R, van der Flier WM, Zwan MD, Adriaanse SF, Boellaard R, Windhorst AD, Barkhof F, Lammertsma AA, Scheltens P, van Berckel BN. Neurology. 2013 Jan 22;80(4):359-65. doi: 10.1212/WNL.0b013e31827f0889. Epub 2012 Dec 19. PMID: 23255822

Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project.

Morbelli S, Drzezga A, Perneczky R, Frisoni GB, Caroli A, van Berckel BN, Ossenkoppele R, Guedj E, Didic M, Brugnolo A, Sambuceti G, Pagani M, Salmon E, Nobili F. Neurobiol Aging. 2012 Nov;33(11):2533-50. doi: 10.1016/j.neurobiolaging.2012.01.005. Epub 2012 Feb 23. PMID: 22365486

Amyloid burden and metabolic function in early-onset Alzheimer's disease: parietal lobe involvement.
Ossenkoppele R, Zwan MD, Tolboom N, van Assema DM, Adriaanse SF, Kloet RW, Boellaard R, Windhorst AD, Barkhof F, Lammertsma AA, Scheltens P, van der Flier WM, van Berckel BN. Brain. 2012 Jul;135(Pt 7):2115-25. doi: 10.1093/brain/aws113. Epub 2012 May 3. PMID: 22556189

Metabolic networks underlying cognitive reserve in prodromal Alzheimer disease: a European Alzheimer disease consortium project.
Morbelli S, Perneczky R, Drzezga A, Frisoni GB, Caroli A, van Berckel BN, Ossenkoppele R, Guedj E, Didic M, Brugnolo A, Naseri M, Sambuceti G, Pagani M, Nobili F. J Nucl Med. 2013 Jun;54(6):894-902. doi: 10.2967/jnumed.112.113928. Epub 2013 Apr 16. PMID: 23591639 Free article.

Volume of interest-based [18F]fluorodeoxyglucose PET discriminates MCI converting to Alzheimer's disease from healthy controls. A European Alzheimer's Disease Consortium (EADC) study.
Pagani M, De Carli F, Morbelli S, Öberg J, Chincarini A, Frisoni GB, Galluzzi S, Perneczky R, Drzezga A, van Berckel BN, Ossenkoppele R, Didic M, Guedj E, Brugnolo A, Picco A, Arnaldi D, Ferrara M, Buschiazzo A, Sambuceti G, Nobili F. Neuroimage Clin. 2014 Nov 18;7:34-42. doi: 10.1016/j.nicl.2014.11.007. eCollection 2015. PMID: 25610765 Free PMC article.

A standardized [18F]-FDG-PET template for spatial normalization in statistical parametric mapping of dementia.
Della Rosa PA, Cerami C, Gallivanone F, Prestia A, Caroli A, Castiglioni I, Gilardi MC, Frisoni G, Friston K, Ashburner J, Perani D; EADC-PET Consortium. Neuroinformatics. 2014 Oct;12(4):575-93. doi: 10.1007/s12021-014-9235-4. PMID: 24952892

Effect of Shortening the Scan Duration on Quantitative Accuracy of [18F]Flortaucipir Studies.
Tuncel H, Visser D, Yaqub M, Timmers T, Wolters EE, Ossenkoppele R, van der Flier WM, van Berckel BNM, Boellaard R, Golla SSV. Mol Imaging Biol. 2021 Jan 26. doi: 10.1007/s11307-021-01581-5. Online ahead of print. PMID: 33496930

[Amyloid-plaque imaging of the brain using PET].
Ossenkoppele R, Tolboom N, Pijnenburg YA, Lammertsma AA, Scheltens P, van Berckel BN. Ned Tijdschr Geneeskd. 2011;155:A2981. PMID: 21586182 Dutch.

The impact of different 18FDG PET healthy subject scans for comparison with single patient in SPM analysis.
Gallivanone F, Della Rosa PA, Perani D, Gilardi MC, Castiglioni I; EADC-PET Consortium. Q J Nucl Med Mol Imaging. 2017 Mar;61(1):115-132. doi: 10.23736/S1824-4785.16.02749-7. Epub 2014 Dec 5. PMID: 25479418

Summary metrics to assess Alzheimer disease-related hypometabolic pattern with 18F-FDG PET: head-to-head comparison.
Caroli A, Prestia A, Chen K, Ayutyanont N, Landau SM, Madison CM, Haense C, Herholz K, Nobili F, Reiman EM, Jagust WJ, Frisoni GB; EADC-PET Consortium, NEST-DD, and Alzheimer's Disease Neuroimaging Initiative. J Nucl Med. 2012 Apr;53(4):592-600. doi: 10.2967/jnumed.111.094946. Epub 2012 Feb 17. PMID: 22343502 Free PMC article.

A Comparison of Two Statistical Mapping Tools for Automated Brain FDG-PET Analysis in Predicting Conversion to Alzheimer's Disease in Subjects with Mild Cognitive Impairment.
Garibotto V, Trombella S, Antelmi L, Bosco P, Redolfi A, Tabouret-Viaud C, Rager O, Gold G, Giannakopoulos P, Morbelli S, Nobili F, Perneczky R, Didic M, Guedj E, Drzezga A, Ossenkoppele R, Berckel BV, Ratib O, Frisoni GB. Curr Alzheimer Res. 2021 Feb 12. doi: 10.2174/1567205018666210212162443. Online ahead of print. PMID: 33583380

In vivo tau pathology is associated with synaptic loss and altered synaptic function.
Coomans EM, Schoonhoven DN, Tuncel H, Verfaillie SCJ, Wolters EE, Boellaard R, Ossenkoppele R, den Braber A, Scheper W, Schober P, Sweeney SP, Ryan JM, Schuit RC, Windhorst AD, Barkhof F, Scheltens P, Golla SSV, Hillebrand A, Gouw AA, van Berckel BNM. Alzheimers Res Ther. 2021 Feb 5;13(1):35. doi: 10.1186/s13195-021-00772-0. PMID: 33546722 Free PMC article.

Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia.
Salvadó G, Grothe MJ, Groot C, Moscoso A, Schöll M, Gispert JD, Ossenkoppele R; Alzheimer’s Disease Neuroimaging Initiative. Eur J Nucl Med Mol Imaging. 2021 Feb 1. doi: 10.1007/s00259-021-05192-8. Online ahead of print. PMID: 33521872

Disease progression modelling from preclinical Alzheimer's disease (AD) to AD dementia.
Cho SH, Woo S, Kim C, Kim HJ, Jang H, Kim BC, Kim SE, Kim SJ, Kim JP, Jung YH, Lockhart S, Ossenkoppele R, Landau S, Na DL, Weiner M, Kim S, Seo SW. Sci Rep. 2021 Feb 18;11(1):4168. doi: 10.1038/s41598-021-83585-3. PMID: 33603015 Free PMC article.

[Early diagnosis of Alzheimer disease: the role of Positron Emission Tomography (PET)].
van der Flier WM, Ossenkoppele R, van Berckel BN, Scheltens P. Tijdschr Gerontol Geriatr. 2013 Sep;44(4):190-1. doi: 10.1007/s12439-013-0033-5. PMID: 23929236 Dutch. No abstract available.

Quantification of total apolipoprotein E and its isoforms in cerebrospinal fluid from patients with neurodegenerative diseases.
Minta K, Brinkmalm G, Janelidze S, Sjödin S, Portelius E, Stomrud E, Zetterberg H, Blennow K, Hansson O, Andreasson U. Alzheimers Res Ther. 2020 Feb 13;12(1):19. doi: 10.1186/s13195-020-00585-7. PMID: 32054532 Free PMC article

Perspectives in fluid biomarkers in neurodegeneration from the 2019 biomarkers in neurodegenerative diseases course-a joint PhD student course at University College London and University of Gothenburg.
Obrocki P, Khatun A, Ness D, Senkevich K, Hanrieder J, Capraro F, Mattsson N, Andreasson U, Portelius E, Ashton NJ, Blennow K, Schöll M, Paterson RW, Schott JM, Zetterberg H. Alzheimers Res Ther. 2020 Feb 28;12(1):20. doi: 10.1186/s13195-020-00586-6. PMID: 32111242 Free PMC article. Review

Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders.
Olsson B, Portelius E, Cullen NC, Sandelius Å, Zetterberg H, Andreasson U, Höglund K, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk D, McCluskey L, Elman L, Shaw LM, Toledo JB, McBride J, Hernandez-Con P, Lee VM, Trojanowski JQ, Blennow K. JAMA Neurol. 2019 Mar 1;76(3):318-325. doi: 10.1001/jamaneurol.2018.3746.

Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology.
Blennow K, Chen C, Cicognola C, Wildsmith KR, Manser PT, Bohorquez SMS, Zhang Z, Xie B, Peng J, Hansson O, Kvartsberg H, Portelius E, Zetterberg H, Lashley T, Brinkmalm G, Kerchner GA, Weimer RM, Ye K, Höglund K. Brain. 2020 Feb 1;143(2):650-660. doi: 10.1093/brain/awz346. PMID: 31834365

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
Alić I, Goh PA, Murray A, Portelius E, Gkanatsiou E, Gough G, Mok KY, Koschut D, Brunmeir R, Yeap YJ, O'Brien NL, Groet J, Shao X, Havlicek S, Dunn NR, Kvartsberg H, Brinkmalm G, Hithersay R, Startin C, Hamburg S, Phillips M, Pervushin K, Turmaine M, Wallon D, Rovelet-Lecrux A, Soininen H, Volpi E, Martin JE, Foo JN, Becker DL, Rostagno A, Ghiso J, Krsnik Ž, Šimić G, Kostović I, Mitrečić D; LonDownS Consortium, Francis PT, Blennow K, Strydom A, Hardy J, Zetterberg H, Nižetić D. Mol Psychiatry. 2020 Jul 10. doi: 10.1038/s41380-020-0806-5. Online ahead of print. PMID: 32647257

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease.
Cicognola C, Brinkmalm G, Wahlgren J, Portelius E, Gobom J, Cullen NC, Hansson O, Parnetti L, Constantinescu R, Wildsmith K, Chen HH, Beach TG, Lashley T, Zetterberg H, Blennow K, Höglund K. Acta Neuropathol. 2019 Feb;137(2):279-296. doi: 10.1007/s00401-018-1948-2. Epub 2018 Dec 13. PMID: 30547227 Free PMC article

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease.
Cicognola C, Brinkmalm G, Wahlgren J, Portelius E, Gobom J, Cullen NC, Hansson O, Parnetti L, Constantinescu R, Wildsmith K, Chen HH, Beach TG, Lashley T, Zetterberg H, Blennow K, Höglund K. Acta Neuropathol. 2019 Feb;137(2):279-296. doi: 10.1007/s00401-018-1948-2. Epub 2018 Dec 13. PMID: 30547227 Free PMC article

First amyloid β1-42 certified reference material for re-calibrating commercial immunoassays.
Boulo S, Kuhlmann J, Andreasson U, Brix B, Venkataraman I, Herbst V, Rutz S, Manuilova E, Vandijck M, Dekeyser F, Bjerke M, Pannee J, Charoud-Got J, Auclair G, Mazoua S, Pinski G, Trapmann S, Schimmel H, Emons H, Quaglia M, Portelius E, Korecka M, Shaw LM, Lame M, Chambers E, Vanderstichele H, Stoops E, Leinenbach A, Bittner T, Jenkins RG, Kostanjevecki V, Lewczuk P, Gobom J, Zetterberg H, Zegers I, Blennow K. Alzheimers Dement. 2020 Nov;16(11):1493-1503. doi: 10.1002/alz.12145. Epub 2020 Aug 4. PMID: 3275501

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain.
Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM. Brain. 2019 May 1;142(5):1441-1457. doi: 10.1093/brain/awz066. PMID: 31032851 Free PMC articleBas du formulaire

First amyloid β1-42 certified reference material for re-calibrating commercial immunoassays.
Boulo S, Kuhlmann J, Andreasson U, Brix B, Venkataraman I, Herbst V, Rutz S, Manuilova E, Vandijck M, Dekeyser F, Bjerke M, Pannee J, Charoud-Got J, Auclair G, Mazoua S, Pinski G, Trapmann S, Schimmel H, Emons H, Quaglia M, Portelius E, Korecka M, Shaw LM, Lame M, Chambers E, Vanderstichele H, Stoops E, Leinenbach A, Bittner T, Jenkins RG, Kostanjevecki V, Lewczuk P, Gobom J, Zetterberg H, Zegers I, Blennow K. Alzheimers Dement. 2020 Nov;16(11):1493-1503. doi: 10.1002/alz.12145. Epub 2020 Aug 4. PMID: 32755010

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain.
Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM. Brain. 2019 May 1;142(5):1441-1457. doi: 10.1093/brain/awz066. PMID: 31032851 Free PMC article.

Cerebrospinal Fluid Concentrations of Extracellular Matrix Proteins in Alzheimer's Disease.
Minta K, Portelius E, Janelidze S, Hansson O, Zetterberg H, Blennow K, Andreasson U. J Alzheimers Dis. 2019;69(4):1213-1220. doi: 10.3233/JAD-190187. PMID: 31156172

Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta.
Arber C, Toombs J, Lovejoy C, Ryan NS, Paterson RW, Willumsen N, Gkanatsiou E, Portelius E, Blennow K, Heslegrave A, Schott JM, Hardy J, Lashley T, Fox NC, Zetterberg H, Wray S. Mol Psychiatry. 2020 Nov;25(11):2919-2931. doi: 10.1038/s41380-019-0410-8. Epub 2019 Apr 12. PMID: 30980041 Free PMC article.

Neurogranin as a potential synaptic marker in the cerebrospinal fluid of patients with a first episode psychosis.
Santillo AF, Lundgren S, Xu C, Orhan F, Fatouros-Bergman H, Blennow K, Zetterberg H, Portelius E; Karolinska Schizophrenia Project (KaSP) Consortium, Cervenka S, Jönsson EG, Erhardt S, Engberg G. Schizophr Res. 2019 Jun;208:490-492. doi: 10.1016/j.schres.2019.01.010. Epub 2019 Feb 4. PMID: 30733168 No abstract available.

Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments.
Grant MKO, Handoko M, Rozga M, Brinkmalm G, Portelius E, Blennow K, Ashe KH, Zahs KR, Liu P. PLoS One. 2019 Feb 28;14(2):e0212815. doi: 10.1371/journal.pone.0212815. eCollection 2019. PMID: 30817799 Free PMC article.

Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain injury.
Minta K, Brinkmalm G, Al Nimer F, Thelin EP, Piehl F, Tullberg M, Jeppsson A, Portelius E, Zetterberg H, Blennow K, Andreasson U. Sci Rep. 2020 Oct 22;10(1):18075. doi: 10.1038/s41598-020-75233-z. PMID: 33093584 Free PMC article.

Cerebrospinal fluid brevican and neurocan fragment patterns in human traumatic brain injury.
Minta K, Brinkmalm G, Thelin EP, Al Nimer F, Piehl F, Tullberg M, Jeppsson A, Portelius E, Zetterberg H, Blennow K, Andreasson U. Clin Chim Acta. 2021 Jan;512:74-83. doi: 10.1016/j.cca.2020.11.017. Epub 2020 Dec 2. PMID: 33275942

Fluid-based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative diseases.
Brinkmalm A, Portelius E, Brinkmalm G, Pannee J, Dahlén R, Gobom J, Blennow K, Zetterberg H. J Neurochem. 2019 Nov;151(4):417-434. doi: 10.1111/jnc.14594. Epub 2018 Nov 12. PMID: 30238462 Review

A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease.
Sepulveda-Falla D, Chavez-Gutierrez L, Portelius E, Vélez JI, Dujardin S, Barrera-Ocampo A, Dinkel F, Hagel C, Puig B, Mastronardi C, Lopera F, Hyman BT, Blennow K, Arcos-Burgos M, de Strooper B, Glatzel M. Acta Neuropathol. 2020 Dec 14. doi: 10.1007/s00401-020-02249-0. Online ahead of print. PMID: 33319314

A distinct brain beta amyloid signature in cerebral amyloid angiopathy compared to Alzheimer's disease.
Gkanatsiou E, Portelius E, Toomey CE, Blennow K, Zetterberg H, Lashley T, Brinkmalm G. Neurosci Lett. 2019 May 14;701:125-131. doi: 10.1016/j.neulet.2019.02.033. Epub 2019 Feb 23. PMID: 30807796

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.
Weiffert T, Meisl G, Flagmeier P, De S, Dunning CJR, Frohm B, Zetterberg H, Blennow K, Portelius E, Klenerman D, Dobson CM, Knowles TPJ, Linse S. ACS Chem Neurosci. 2019 May 15;10(5):2374-2384. doi: 10.1021/acschemneuro.8b00676. Epub 2019 Mar 8. PMID: 30793584

Brevican and Neurocan Peptides as Potential Cerebrospinal Fluid Biomarkers for Differentiation Between Vascular Dementia and Alzheimer's Disease.
Minta K, Brinkmalm G, Portelius E, Johansson P, Svensson J, Kettunen P, Wallin A, Zetterberg H, Blennow K, Andreasson U. J Alzheimers Dis. 2020 Dec 17. doi: 10.3233/JAD-201039. Online ahead of print. PMID: 33337373

Dynamics of extracellular matrix proteins in cerebrospinal fluid and serum and their relation to clinical outcome in human traumatic brain injury.
Minta K, Cullen NC, Nimer FA, Thelin EP, Piehl F, Clarin M, Tullberg M, Jeppsson A, Portelius E, Zetterberg H, Blennow K, Andreasson U. Clin Chem Lab Med. 2019 Sep 25;57(10):1565-1573. doi: 10.1515/cclm-2019-0034. PMID: 30980710 Free article

Neurofilament changes in serum and cerebrospinal fluid after acute ischemic stroke.
Pujol-Calderón F, Portelius E, Zetterberg H, Blennow K, Rosengren LE, Höglund K. Neurosci Lett. 2019 Apr 17;698:58-63. doi: 10.1016/j.neulet.2018.12.042. Epub 2018 Dec 29. PMID: 3059926

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.
Sandelius Å, Portelius E, Källén Å, Zetterberg H, Rot U, Olsson B, Toledo JB, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, Elman L, Kostanjevecki V, Vandijck M, McBride J, Trojanowski JQ, Blennow K. Alzheimers Dement. 2019 Jan;15(1):55-64. doi: 10.1016/j.jalz.2018.08.006. Epub 2018 Oct 12. PMID: 30321501 Free PMC article

The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer's disease.
Kvartsberg H, Lashley T, Murray CE, Brinkmalm G, Cullen NC, Höglund K, Zetterberg H, Blennow K, Portelius E. Acta Neuropathol. 2019 Jan;137(1):89-102. doi: 10.1007/s00401-018-1910-3. Epub 2018 Sep 22. PMID: 30244311 Free PMC articl

Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70.
Keshavan A, Pannee J, Karikari TK, Rodriguez JL, Ashton NJ, Nicholas JM, Cash DM, Coath W, Lane CA, Parker TD, Lu K, Buchanan SM, Keuss SE, James SN, Murray-Smith H, Wong A, Barnes A, Dickson JC, Heslegrave A, Portelius E, Richards M, Fox NC, Zetterberg H, Blennow K, Schott JM. Brain. 2021 Jan 22:awaa403. doi: 10.1093/brain/awaa403. Online ahead of print. PMID: 33479777

Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts.
Karikari TK, Pascoal TA, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, Chamoun M, Savard M, Kang MS, Therriault J, Schöll M, Massarweh G, Soucy JP, Höglund K, Brinkmalm G, Mattsson N, Palmqvist S, Gauthier S, Stomrud E, Zetterberg H, Hansson O, Rosa-Neto P, Blennow K. Lancet Neurol. 2020 May;19(5):422-433. doi: 10.1016/S1474-4422(20)30071-5. PMID: 32333900

Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer's disease.
Whelan CD, Mattsson N, Nagle MW, Vijayaraghavan S, Hyde C, Janelidze S, Stomrud E, Lee J, Fitz L, Samad TA, Ramaswamy G, Margolin RA, Malarstig A, Hansson O. Acta Neuropathol Commun. 2019 Nov 6;7(1):169. doi: 10.1186/s40478-019-0795-2. PMID: 31694701 Free PMC article.

Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia.
Janelidze S, Mattsson N, Palmqvist S, Smith R, Beach TG, Serrano GE, Chai X, Proctor NK, Eichenlaub U, Zetterberg H, Blennow K, Reiman EM, Stomrud E, Dage JL, Hansson O. Nat Med. 2020 Mar;26(3):379-386. doi: 10.1038/s41591-020-0755-1. Epub 2020 Mar 2. PMID: 32123385

Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease.
Mattsson N, Cullen NC, Andreasson U, Zetterberg H, Blennow K. JAMA Neurol. 2019 Jul 1;76(7):791-799. doi: 10.1001/jamaneurol.2019.0765. PMID: 31009028 Free PMC article.

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.
Bridel C, van Wieringen WN, Zetterberg H, Tijms BM, Teunissen CE; and the NFL Group, Alvarez-Cermeño JC, Andreasson U, Axelsson M, Bäckström DC, Bartos A, Bjerke M, Blennow K, Boxer A, Brundin L, Burman J, Christensen T, Fialová L, Forsgren L, Frederiksen JL, Gisslén M, Gray E, Gunnarsson M, Hall S, Hansson O, Herbert MK, Jakobsson J, Jessen-Krut J, Janelidze S, Johannsson G, Jonsson M, Kappos L, Khademi M, Khalil M, Kuhle J, Landén M, Leinonen V, Logroscino G, Lu CH, Lycke J, Magdalinou NK, Malaspina A, Mattsson N, Meeter LH, Mehta SR, Modvig S, Olsson T, Paterson RW, Pérez-Santiago J, Piehl F, Pijnenburg YAL, Pyykkö OT, Ragnarsson O, Rojas JC, Romme Christensen J, Sandberg L, Scherling CS, Schott JM, Sellebjerg FT, Simone IL, Skillbäck T, Stilund M, Sundström P, Svenningsson A, Tortelli R, Tortorella C, Trentini A, Troiano M, Turner MR, van Swieten JC, Vågberg M, Verbeek MM, Villar LM, Visser PJ, Wallin A, Weiss A, Wikkelsø C, Wild EJ. JAMA Neurol. 2019 Jun 17;76(9):1035-48. doi: 10.1001/jamaneurol.2019.1534. Online ahead of print. PMID: 31206160 Free PMC article.

Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease.
Palmqvist S, Insel PS, Stomrud E, Janelidze S, Zetterberg H, Brix B, Eichenlaub U, Dage JL, Chai X, Blennow K, Mattsson N, Hansson O. EMBO Mol Med. 2019 Dec;11(12):e11170. doi: 10.15252/emmm.201911170. Epub 2019 Nov 11. PMID: 31709776 Free PMC article.

Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease.
Janelidze S, Stomrud E, Smith R, Palmqvist S, Mattsson N, Airey DC, Proctor NK, Chai X, Shcherbinin S, Sims JR, Triana-Baltzer G, Theunis C, Slemmon R, Mercken M, Kolb H, Dage JL, Hansson O. Nat Commun. 2020 Apr 3;11(1):1683. doi: 10.1038/s41467-020-15436-0. PMID: 32246036 Free PMC article.

Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease.
Mattsson N, Andreasson U, Zetterberg H, Blennow K; Alzheimer’s Disease Neuroimaging Initiative. JAMA Neurol. 2017 May 1;74(5):557-566. doi: 10.1001/jamaneurol.2016.6117. PMID: 28346578 Free PMC article.

Biomarkers for tau pathology.
Schöll M, Maass A, Mattsson N, Ashton NJ, Blennow K, Zetterberg H, Jagust W. Mol Cell Neurosci. 2019 Jun;97:18-33. doi: 10.1016/j.mcn.2018.12.001. Epub 2018 Dec 7. PMID: 30529601 Free PMC article. Review.

Performance of Fully Automated Plasma Assays as Screening Tests for Alzheimer Disease-Related β-Amyloid Status.
Palmqvist S, Janelidze S, Stomrud E, Zetterberg H, Karl J, Zink K, Bittner T, Mattsson N, Eichenlaub U, Blennow K, Hansson O. JAMA Neurol. 2019 Jun 24;76(9):1060-9. doi: 10.1001/jamaneurol.2019.1632. Online ahead of print. PMID: 31233127 Free PMC article.

Perspectives in fluid biomarkers in neurodegeneration from the 2019 biomarkers in neurodegenerative diseases course-a joint PhD student course at University College London and University of Gothenburg.
Obrocki P, Khatun A, Ness D, Senkevich K, Hanrieder J, Capraro F, Mattsson N, Andreasson U, Portelius E, Ashton NJ, Blennow K, Schöll M, Paterson RW, Schott JM, Zetterberg H. Alzheimers Res Ther. 2020 Feb 28;12(1):20. doi: 10.1186/s13195-020-00586-6. PMID: 32111242 Free PMC article. Review.

CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease.
Janelidze S, Mattsson N, Stomrud E, Lindberg O, Palmqvist S, Zetterberg H, Blennow K, Hansson O. Neurology. 2018 Aug 28;91(9):e867-e877. doi: 10.1212/WNL.0000000000006082. Epub 2018 Jul 27. PMID: 30054439 Free PMC article.

Cerebrospinal fluid levels of neurogranin in Parkinsonian disorders.
Hall S, Janelidze S, Zetterberg H, Brix B, Mattsson N, Surova Y, Blennow K, Hansson O. Mov Disord. 2020 Mar;35(3):513-518. doi: 10.1002/mds.27950. Epub 2019 Dec 13. PMID: 31837067

Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.
Bergeron D, Gorno-Tempini ML, Rabinovici GD, Santos-Santos MA, Seeley W, Miller BL, Pijnenburg Y, Keulen MA, Groot C, van Berckel BNM, van der Flier WM, Scheltens P, Rohrer JD, Warren JD, Schott JM, Fox NC, Sanchez-Valle R, Grau-Rivera O, Gelpi E, Seelaar H, Papma JM, van Swieten JC, Hodges JR, Leyton CE, Piguet O, Rogalski EJ, Mesulam MM, Koric L, Nora K, Pariente J, Dickerson B, Mackenzie IR, Hsiung GR, Belliard S, Irwin DJ, Wolk DA, Grossman M, Jones M, Harris J, Mann D, Snowden JS, Chrem-Mendez P, Calandri IL, Amengual AA, Miguet-Alfonsi C, Magnin E, Magnani G, Santangelo R, Deramecourt V, Pasquier F, Mattsson N, Nilsson C, Hansson O, Keith J, Masellis M, Black SE, Matías-Guiu JA, Cabrera-Martin MN, Paquet C, Dumurgier J, Teichmann M, Sarazin M, Bottlaender M, Dubois B, Rowe CC, Villemagne VL, Vandenberghe R, Granadillo E, Teng E, Mendez M, Meyer PT, Frings L, Lleó A, Blesa R, Fortea J, Seo SW, Diehl-Schmid J, Grimmer T, Frederiksen KS, Sánchez-Juan P, Chételat G, Jansen W, Bouchard RW, Laforce RJ, Visser PJ, Ossenkoppele R. Ann Neurol. 2018 Nov;84(5):729-740. doi: 10.1002/ana.25333. PMID: 30255971 Free PMC article.

Apathy and anxiety are early markers of Alzheimer's disease.
Johansson M, Stomrud E, Lindberg O, Westman E, Johansson PM, van Westen D, Mattsson N, Hansson O. Neurobiol Aging. 2020 Jan;85:74-82. doi: 10.1016/j.neurobiolaging.2019.10.008. Epub 2019 Oct 19. PMID: 31735378

 

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.
Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleó A, Mintun MA, Wallin A, Engelborghs S, Na DL, Chételat G, Molinuevo JL, Landau SM, Mattsson N, Kornhuber J, Sabri O, Rowe CC, Parnetti L, Popp J, Fladby T, Jagust WJ, Aalten P, Lee DY, Vandenberghe R, Resende de Oliveira C, Kapaki E, Froelich L, Ivanoiu A, Gabryelewicz T, Verbeek MM, Sanchez-Juan P, Hildebrandt H, Camus V, Zboch M, Brooks DJ, Drzezga A, Rinne JO, Newberg A, de Mendonça A, Sarazin M, Rabinovici GD, Madsen K, Kramberger MG, Nordberg A, Mok V, Mroczko B, Wolk DA, Meyer PT, Tsolaki M, Scheltens P, Verhey FRJ, Visser PJ; Amyloid Biomarker Study Group, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BNM, Blennow K, van Buchem MA, Cavedo E, Chen K, Chipi E, Cohen AD, Förster S, Fortea J, Frederiksen KS, Freund-Levi Y, Gkatzima O, Gordon MF, Grimmer T, Hampel H, Hausner L, Hellwig S, Herukka SK, Johannsen P, Klimkowicz-Mrowiec A, Köhler S, Koglin N, van Laere K, de Leon M, Lisetti V, Maier W, Marcusson J, Meulenbroek O, Møllergård HM, Morris JC, Nordlund A, Novak GP, Paraskevas GP, Perera G, Peters O, Ramakers IHGB, Rami L, Rodríguez-Rodríguez E, Roe CM, Rot U, Rüther E, Santana I, Schröder J, Seo SW, Soininen H, Spiru L, Stomrud E, Struyfs H, Teunissen CE, Vos SJB, van Waalwijk van Doorn LJC, Waldemar G, Wallin ÅK, Wiltfang J, Zetterberg H. JAMA Psychiatry. 2018 Jan 1;75(1):84-95. doi: 10.1001/jamapsychiatry.2017.3391. PMID: 29188296 Free PMC article.

Staging β-Amyloid Pathology With Amyloid Positron Emission Tomography.
Mattsson N, Palmqvist S, Stomrud E, Vogel J, Hansson O. JAMA Neurol. 2019 Jul 17;76(11). doi: 10.1001/jamaneurol.2019.2214. Online ahead of print. PMID: 31314895 Free PMC article.

Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders.
Ossenkoppele R, Rabinovici GD, Smith R, Cho H, Schöll M, Strandberg O, Palmqvist S, Mattsson N, Janelidze S, Santillo A, Ohlsson T, Jögi J, Tsai R, La Joie R, Kramer J, Boxer AL, Gorno-Tempini ML, Miller BL, Choi JY, Ryu YH, Lyoo CH, Hansson O. JAMA. 2018 Sep 18;320(11):1151-1162. doi: 10.1001/jama.2018.12917. PMID: 30326496 Free PMC article.

Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest.
Moseby-Knappe M, Mattsson N, Nielsen N, Zetterberg H, Blennow K, Dankiewicz J, Dragancea I, Friberg H, Lilja G, Insel PS, Rylander C, Westhall E, Kjaergaard J, Wise MP, Hassager C, Kuiper MA, Stammet P, Wanscher MCJ, Wetterslev J, Erlinge D, Horn J, Pellis T, Cronberg T. JAMA Neurol. 2019 Jan 1;76(1):64-71. doi: 10.1001/jamaneurol.2018.3223. PMID: 30383090 Free PMC article.

The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable.
Knopman DS, Haeberlein SB, Carrillo MC, Hendrix JA, Kerchner G, Margolin R, Maruff P, Miller DS, Tong G, Tome MB, Murray ME, Nelson PT, Sano M, Mattsson N, Sultzer DL, Montine TJ, Jack CR Jr, Kolb H, Petersen RC, Vemuri P, Canniere MZ, Schneider JA, Resnick SM, Romano G, van Harten AC, Wolk DA, Bain LJ, Siemers E. Alzheimers Dement. 2018 Apr;14(4):563-575. doi: 10.1016/j.jalz.2018.03.002. PMID: 29653607 Free PMC article. Review.

Primary fatty amides are potential plasma biomarkers for AD.
Mattsson N, Hansson O. Nat Rev Neurol. 2019 Sep;15(9):498-499. doi: 10.1038/s41582-019-0229-6. PMID: 31253949 No abstract available.

The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable.
Knopman DS, Haeberlein SB, Carrillo MC, Hendrix JA, Kerchner G, Margolin R, Maruff P, Miller DS, Tong G, Tome MB, Murray ME, Nelson PT, Sano M, Mattsson N, Sultzer DL, Montine TJ, Jack CR Jr, Kolb H, Petersen RC, Vemuri P, Canniere MZ, Schneider JA, Resnick SM, Romano G, van Harten AC, Wolk DA, Bain LJ, Siemers E. Alzheimers Dement. 2018 Apr;14(4):563-575. doi: 10.1016/j.jalz.2018.03.002. PMID: 29653607 Free PMC article. Review.

Primary fatty amides are potential plasma biomarkers for AD.
Mattsson N, Hansson O. Nat Rev Neurol. 2019 Sep;15(9):498-499. doi: 10.1038/s41582-019-0229-6. PMID: 31253949 No abstract available.

Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease.
Ossenkoppele R, Smith R, Ohlsson T, Strandberg O, Mattsson N, Insel PS, Palmqvist S, Hansson O. Neurology. 2019 Feb 5;92(6):e601-e612. doi: 10.1212/WNL.0000000000006875. Epub 2019 Jan 9. PMID: 30626656 Free PMC article.

Predicting diagnosis and cognition with 18F-AV-1451 tau PET and structural MRI in Alzheimer's disease.
Mattsson N, Insel PS, Donohue M, Jögi J, Ossenkoppele R, Olsson T, Schöll M, Smith R, Hansson O. Alzheimers Dement. 2019 Apr;15(4):570-580. doi: 10.1016/j.jalz.2018.12.001. Epub 2019 Jan 25. PMID: 30639421

β-amyloid pathology and hippocampal atrophy are independently associated with memory function in cognitively healthy elderly.
Svenningsson AL, Stomrud E, Insel PS, Mattsson N, Palmqvist S, Hansson O. Sci Rep. 2019 Aug 1;9(1):11180. doi: 10.1038/s41598-019-47638-y. PMID: 31371787 Free PMC article.

CSF biomarkers in neurodegenerative diseases.
Mattsson N. Clin Chem Lab Med. 2011 Mar;49(3):345-52. doi: 10.1515/CCLM.2011.082. Epub 2011 Feb 9. PMID: 21303297 Review.

Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest.
Grand J, Kjaergaard J, Nielsen N, Friberg H, Cronberg T, Bro-Jeppesen J, Karsdal MA, Nielsen HB, Frydland M, Henriksen K, Mattsson N, Zetterberg H, Hassager C. Biomarkers. 2019 Sep;24(6):584-591. doi: 10.1080/1354750X.2019.1609580. Epub 2019 May 31. PMID: 31017476

Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.
Nosheny RL, Insel PS, Mattsson N, Tosun D, Buckley S, Truran D, Schuff N, Aisen PS, Weiner MW; Alzheimer's Disease Neuroimaging Initiative. Neurobiol Aging. 2019 Oct;82:110-119. doi: 10.1016/j.neurobiolaging.2019.07.005. Epub 2019 Jul 22. PMID: 31437719 Free PMC article.

Acute reduction of cerebrospinal fluid volume prior to spinal anesthesia: implications for sensory block extent.
Bjurström MF, Mattsson N, Harsten A, Dietz N, Bodelsson M. Minerva Anestesiol. 2020 Jun;86(6):636-644. doi: 10.23736/S0375-9393.20.14138-5. Epub 2020 Jan 30. PMID: 32013330

Predictive Factors of Concerns about Falling in People with Parkinson's Disease: A 3-Year Longitudinal Study.
Lindh-Rengifo M, Jonasson SB, Mattsson N, Ullén S, Nilsson MH. Parkinsons Dis. 2019 Dec 12;2019:4747320. doi: 10.1155/2019/4747320. eCollection 2019. PMID: 31915520 Free PMC article.

Apolipoprotein E genotypes and longevity across dementia disorders.
Skillbäck T, Lautner R, Mattsson N, Schott JM, Skoog I, Nägga K, Kilander L, Wimo A, Winblad B, Eriksdotter M, Blennow K, Zetterberg H. Alzheimers Dement. 2018 Jul;14(7):895-901. doi: 10.1016/j.jalz.2018.02.003. Epub 2018 Mar 13. PMID: 29548722

Predicting clinical decline and conversion to Alzheimer's disease or dementia using novel Elecsys Aβ(1-42), pTau and tTau CSF immunoassays.
Blennow K, Shaw LM, Stomrud E, Mattsson N, Toledo JB, Buck K, Wahl S, Eichenlaub U, Lifke V, Simon M, Trojanowski JQ, Hansson O. Sci Rep. 2019 Dec 13;9(1):19024. doi: 10.1038/s41598-019-54204-z. PMID: 31836810 Free PMC article.Bas du formulaire

Data-driven approaches for tau-PET imaging biomarkers in Alzheimer's disease.
Vogel JW, Mattsson N, Iturria-Medina Y, Strandberg OT, Schöll M, Dansereau C, Villeneuve S, van der Flier WM, Scheltens P, Bellec P, Evans AC, Hansson O, Ossenkoppele R; Alzheimer's Disease Neuroimaging Initiative; Swedish BioFINDER Study. Hum Brain Mapp. 2019 Feb 1;40(2):638-651. doi: 10.1002/hbm.24401. Epub 2018 Oct 19. PMID: 30368979 Free PMC article.

Associations between partial pressure of oxygen and neurological outcome in out-of-hospital cardiac arrest patients: an explorative analysis of a randomized trial.
Ebner F, Ullén S, Åneman A, Cronberg T, Mattsson N, Friberg H, Hassager C, Kjærgaard J, Kuiper M, Pelosi P, Undén J, Wise MP, Wetterslev J, Nielsen N. Crit Care. 2019 Jan 28;23(1):30. doi: 10.1186/s13054-019-2322-z. PMID: 30691510 Free PMC article. Clinical Trial. ID: 24944261 Free PMC article.

Cerebrospinal fluid neurofilament light is associated with survival in mitochondrial disease patients.
Sofou K, Shahim P, Tulinius M, Blennow K, Zetterberg H, Mattsson N, Darin N. Mitochondrion. 2019 May;46:228-235. doi: 10.1016/j.mito.2018.07.002. Epub 2018 Jul 9. PMID: 30004022

Comparing 18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease.
Mattsson N, Smith R, Strandberg O, Palmqvist S, Schöll M, Insel PS, Hägerström D, Ohlsson T, Zetterberg H, Blennow K, Jögi J, Hansson O. Neurology. 2018 Jan 30;90(5):e388-e395. doi: 10.1212/WNL.0000000000004887. Epub 2018 Jan 10. PMID: 29321235 Free PMC article.