A One Health Study of Monkeypox: Human Infection, Animal Reservoir, Disease Ecology, and Diagnostic Tools

A One Health Study of Monkeypox: Human Infection, Animal Reservoir, Disease Ecology, and Diagnostic Tools

This study is led by Professor Arnaud Fontanet, Director of the Emerging Diseases Epidemiology unit at the Institut Pasteur, who also heads the AFRIPOX project on the same topic. Alexandre Hassanin, an evolutionary zoologist specializing in tropical mammals at the Institut de SYstématique, Évolution, Biodiversité (Paris, France), is assisting Professor Fontanet with the taxonomic identification of animal hosts and phylogeographic analyses. Nicolas Berthet and Antoine Gessain, virologists specializing in emerging viruses at the Institut Pasteur de Paris, and Alexandre Hassanin, are assisting Professor Fontanet with the Phylogenetic analysis of virus strains.

Duration of the project : 2020-2022 (currently underway)

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Monkeypox, an emerging Orthopoxvirus with a similar disease presentation to smallpox, is a zoonotic virus which can spread from person to person. Although to date, monkeypox events have erupted in West and Central African rainforests, their frequency, size, and geographic scope have expanded substantially in recent years. Imported cases have been detected in multiple locations, including Europe. Yet many aspects of this emerging infectious disease remain unclear, including its animal reservoir, its risk factors for zoonotic and interhuman transmission, and ecological characteristics that may facilitate monkeypox emergence. Consequently, the 2018 WHO Research & Development Blueprint designated monkeypox as an emerging disease requiring “accelerated research & development and public health action”. The AFRIPOX collaboration will mobilize an international, multidisciplinary One Health partnership spanning epidemiology, anthropology, zoology, environmental ecology, virology and mathematical modelling to tackle four research objectives investigating monkeypox at the human-animal-ecosystem interface.

The research engineer recruited for this multidisciplinary project will analyze DNA sequences from the animal species hosting the virus in order to test the hypothesis of co-evolution between the virus and its reservoir host.

In collaboration with the other project teams, the research engineer will analyze the genetic sequences of viruses isolated from infected animals and humans in order to:

  • Identify the animal reservoir and secondary hosts of monkeypox in areas of Central Africa where monkeypox is known to circulate 
  • Understand the relationships and differences between the viral strains circulating in human and animal populations  

Identifying the animal species involved in the emergence of monkeypox and the geographical distribution of these species will help to pinpoint zones at risk of zoonotic spillover and enhance outbreak preparedness activities. Describing phylogenetic links between human cases and/or possible animal cases will help to better understand how monkeypox circulates in Central Africa. A better understanding of the emergence of human epidemics is essential to control the disease.