SCOR Young European Researcher Prize for research into Alzheimer’s disease
The SCOR Corporate Foundation for Science is proud to support France’s Alzheimer’s Research Foundation through this SCOR Young European Researcher Prize.
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Extending and reinforcing a partnership initiated by SCOR in 2008, the SCOR Corporate Foundation for Science signed a sponsorship agreement with the research program of France’s Alzheimer’s Research Foundation (Fondation Recherche Alzheimer) on June 12, 2013. As well as creating an annual award for young European researchers, the agreement enables the Research Foundation to continue observing a cohort of patients as part of a long-term study of Alzheimer’s sufferers, and to promote cooperative research in this field with scientists from other countries.
Axel Montagne, winner of the 2021 European Young Researcher Award-SCOR
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Meet the prizewinners
2022
Alberto Benussi
The 2022 SCOR Young European Researcher Prize for research into Alzheimer’s disease was awarded to neurologist Dr Alberto Benussi, 36, currently Assistant Professor of Neurology at Brescia Hospital (Italy) where he heads the center for cognitive disorders. Professor Alberto Benussi completed his training in Rome (lRCCS in Santa Lucia), and then in London (Queen Square Institute of Neurology). His innovative work focuses on non-invasive brain stimulation methods that may benefit patients suffering from neurodegenerative diseases.
He is currently looking to develop a device that could be used at home to assess the cognitive benefits of long-term stimulation (repeated low-intensity transcranial electrical stimulation).
2021
Axel Montagne
French researcher Axel Montagne won the award for his research on how cerebrovascular dysfunction contributes to neurodegeneration and cognitive impairment in animal models and humans. In the context of neurodegenerative diseases, he studies the causes and effects of dysfunction of the blood-brain barrier, the main function of which is to isolate the central nervous system from the bloodstream, preventing potentially toxic foreign substances from entering the brain.
Axel Montagne has been a Chancellor’s Fellow at the University of Edinburgh Centre for Clinical Brain Sciences since December 2020, leading a research group at the UK Dementia Research Institute
2020
Renzo Mancuso
The seventh SCOR Young European Researcher Prize for Research into Alzheimer’s disease was awarded to Renzo Mancuso of the Gothenburg University in Sweden. Renzo won the award for his findings on microglia and neuroinflammation, which play a central role in the pathogenesis of Alzheimer’s disease and other neurodegenerative disorders. A young Italian-Argentine biologist, Renzo Mancuso works with Pr. Bart de Strooper at the VIB UAntwerp Center for Molecular Neurology in the Netherlands. His primary focus has been on examining the underlying molecular mechanisms that drive Alzheimer’s disease (AD) and frontotemporal degeneration (FTD), with a special emphasis on inflammatory networks and particularly the contribution of microglia.
Click here to read Renzo's entry form.
2019
Federica Agosta
The 2019 SCOR Young European Researcher Prize for Research into Alzheimer’s disease was awarded to Dr Federica Agosta, medical doctor and researcher at the San Raffaele Hospital in Milan. Using MRI (magnetic resonance imaging) techniques, her work aims to identify functional and structural markers of degeneration to enable early diagnosis of Alzheimer’s and related disorders.
She is also particularly interested in young-onset Alzheimer’s disease. She has published more than 200 articles in specialist scientific journals. The jury of renowned European researchers was chaired by Professor Jean-François Dartigues of the Bordeaux Population Health Research Center.
2018
Rik Ossenkoppele
The 2018 SCOR Young European Researcher Prize for research into Alzheimer’s disease was awarded to Rik Ossenkoppele of the Alzheimer Center at the VU University Medical Center in Amsterdam, the Netherlands.
A Dutch-born Doctor of Science, he is considered one of the most brilliant researchers of his generation. His main work has focused on new neuroimaging tracers – both amyloid markers and tau markers – that make it possible to identify lesions in patients’ brains during a PET scan.
2017
Erik Portelius
On February 12, 2018, the 5th SCOR Young European Researcher Prize for Research into Alzheimer’s disease was presented to Erik Portelius of Sweden’s Gothenburg University, for his findings on a new biomarker that enables earlier detection of the condition.
This new biomarker, a protein called neurogranin, paves the way for a better understanding of the disease. It allows doctors to estimate the extent of the damage to patients’ synapses and also to predict the rate of cognitive decline in patients with mild cognitive impairment. By measuring the new biomarker, the disease can be detected at an earlier stage than previously, since the loss of synapses is believed to occur early in the disease process, perhaps even earlier than neuronal loss.
2016
Niklas Mattson
The Scientific Committee of the French Alzheimer’s Research Foundation, comprised of eight European neurology professors, has named Dr. Niklas Mattson of Sweden’s Lund University as the winner of the 4th SCOR Young European Researcher Prize, which is financed by the SCOR Corporate Foundation for Science. Dr. Niklas Mattson’s original research on biomarkers has improved medical knowledge of disease mechanisms in the early stages of Alzheimer’s disease.
A biomarker can be defined as “a naturally occurring molecule, gene, or characteristic by which a particular pathological or physiological process, disease, etc. can be identified”.
2015
Lawrence Rajendran
The 3rd SCOR Young European Researcher Prize, financed by the SCOR Corporate Foundation for Science, was awarded to Dr Lawrence Rajendran of the University of Zurich.
Lawrence Rajendran’s remarkable work notably deals with the genes that predispose people to develop Alzheimer’s disease. For neurodegenerative diseases it is often impossible to isolate one responsible gene, which was previously the case for Alzheimer’s disease. However, the emergence of functional genomics methods and computational tools has led to advances in the understanding of the complex molecular networks underlying the disease.
2014
Rita Guerreiro
The 2014 SCOR Young European Researcher Prize for Research into Alzheimer’s disease was awarded to Rita Guerreiro, Researcher at the Department of Molecular Neuroscience, University College London (UCL).
This young researcher with Portuguese roots works in the Department of Molecular Neuroscience, University College London (UCL). She was selected for her work on the mutation of the TREM2 gene, which is implicated as a possible risk factor for Alzheimer’s disease and for certain generative diseases such as frontotemporal dementia.
2013
Florence Clavaguera
The 2013 SCOR Young European Researcher Prize for Research into Alzheimer’s disease was awarded to Florence Clavaguera, Researcher at the University Hospital Basel, Switzerland.
In partnership with SCOR, the French Alzheimer’s Research Foundation (Fondation Recherche Alzheimer) has created a Young European Researcher Prize. Worth EUR 10,000, this prize is designed to support and encourage promising research projects by young researchers.
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Publications by the prizewinners
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Alberto Benussi | 10th SCOR Young European Researcher Prize winner (2022)
- Increasing brain gamma activity improves episodic memory and restores cholinergic dysfunction in Alzheimer’s disease.
Benussi A, Cantoni V, Grassi M, Brechet L, Michel CM, Datta A, Thomas C, Gazzina S, Cotelli MS, Bianchi M, Premi E, Gadola Y, Cotelli M, Pengo M, Perrone F, Scolaro M, Archetti S, Solje E, Padovani A, Pascual-Leone A, Borroni B.
Ann Neurol. 2022 Aug;92(2):322-334. doi: 10.1002/ana.26411. Epub 2022 Jun 6. PMID: 35607946 - Transcranial magnetic stimulation distinguishes Alzheimer disease from frontotemporal dementia.
Benussi A, Di Lorenzo F, Dell'Era V, Cosseddu M, Alberici A, Caratozzolo S, Cotelli MS, Micheli A, Rozzini L, Depari A, Flammini A, Ponzo V, Martorana A, Caltagirone C, Padovani A, Koch G, Borroni B. Neurology.
22017 Aug 15;89(7):665-672. doi: 10.1212/WNL.0000000000004232. Epub 2017 Jul 26. PMID: 28747446 - Classification Accuracy of Transcranial Magnetic Stimulation for the Diagnosis of Neurodegenerative Dementias.
Benussi A, Grassi M, Palluzzi F, Koch G, Di Lazzaro V, Nardone R, Cantoni V, Dell'Era V, Premi E, Martorana A, di Lorenzo F, Bonnì S, Ranieri F, Capone F, Musumeci G, Cotelli MS, Padovani A, Borroni B. Ann Neurol.
2020 Mar;87(3):394-404. doi: 10.1002/ana.25677. Epub 2020 Jan 23. PMID: 31925823 - Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, Pedersen NL, Stringa N, Zettergren A, Hernández I, Montrreal L, Antúnez C, Antonell A, Tankard RM, Bis JC, Sims R, Bellenguez C, Quintela I, González-Perez A, Calero M, Franco-Macías E, Macías J, Blesa R, Cervera-Carles L, Menéndez-González M, Frank-García A, Royo JL, Moreno F, Huerto Vilas R, Baquero M, Diez-Fairen M, Lage C, García-Madrona S, García-González P, Alarcón-Martín E, Valero S, Sotolongo-Grau O, Ullgren A, Naj AC, Lemstra AW, Benaque A, Pérez-Cordón A, Benussi A, Rábano A, Padovani A, Squassina A, de Mendonça A, Arias Pastor A, Kok AAL, Meggy A, Pastor AB, Espinosa A, Corma-Gómez A, Martín Montes A, Sanabria Á, DeStefano AL, Schneider A, Haapasalo A, Kinhult Ståhlbom A, Tybjærg-Hansen A, Hartmann AM, Spottke A, Corbatón-Anchuelo A, Rongve A, Borroni B, Arosio B, Nacmias B, Nordestgaard BG, Kunkle BW, Charbonnier C, Abdelnour C, Masullo C, Martínez Rodríguez C, Muñoz-Fernandez C, Dufouil C, Graff C, Ferreira CB, Chillotti C, Reynolds CA, Fenoglio C, Van Broeckhoven C, Clark C, Pisanu C, Satizabal CL, Holmes C, Buiza-Rueda D, Aarsland D, Rujescu D, Alcolea D, Galimberti D, Wallon D, Seripa …
Nat Commun. 2021 Jun 7;12(1):3417. doi: 10.1038/s41467-021-22491-8. PMID: 34099642 - Exposure to gamma tACS in Alzheimer's disease: A randomized, double-blind, sham-controlled, crossover, pilot study.
Benussi A, Cantoni V, Cotelli MS, Cotelli M, Brattini C, Datta A, Thomas C, Santarnecchi E, Pascual-Leone A, Borroni B.
Brain Stimul. 2021 May-Jun;14(3):531-540. doi: 10.1016/j.brs.2021.03.007. Epub 2021 Mar 21. PMID: 33762220 - Cortical Circuitry and Synaptic Dysfunctions in Alzheimer's Disease and Other Dementias.
Ranieri F, Benussi A, Cantone M, Ferreri F, Márquez-Ruiz J.
Neural Plast. 2021 Jul 29;2021:9796576. doi: 10.1155/2021/9796576. eCollection 2021. PMID: 34394342 - Clinical, genetic, and neuroimaging features of Early Onset Alzheimer Disease: the challenges of diagnosis and treatment.
Alberici A, Benussi A, Premi E, Borroni B, Padovani A.
Curr Alzheimer Res. 2014;11(10):909-17. doi: 10.2174/1567205011666141107151606. PMID: 25387334 - Differences Between Plasma and Cerebrospinal Fluid p-tau181 and p-tau231 in Early Alzheimer's Disease.
Pilotto A, Parigi M, Bonzi G, Battaglio B, Ferrari E, Mensi L, Benussi A, Caratozzolo S, Cosseddu M, Turrone R, Archetti S, Ashton NJ, Zetterberg H, Giliani S, Padovani A.
J Alzheimers Dis. 2022;87(3):991-997. doi: 10.3233/JAD-215646. PMID: 35404280 - Cortical network modularity changes along the course of frontotemporal and Alzheimer's dementing diseases.
Franciotti R, Moretti DV, Benussi A, Ferri L, Russo M, Carrarini C, Barbone F, Arnaldi D, Falasca NW, Koch G, Cagnin A, Nobili FM, Babiloni C, Borroni B, Padovani A, Onofrj M, Bonanni L; FTD Italian study group-SINDEM.
Neurobiol Aging. 2022 Feb;110:37-46. doi: 10.1016/j.neurobiolaging.2021.10.016. Epub 2021 Nov 1. PMID: 34847523 - Diagnostic Accuracy of the Five-Word Test for Mild Cognitive Impairment Due to Alzheimer's Disease.
Fornari C, Mori F, Zoppi N, Libri I, Silvestri C, Cosseddu M, Turrone R, Maffi M, Caratozzolo S, Borroni B, Padovani A, Benussi A.
Neurol Int. 2022 Apr 6;14(2):357-367. doi: 10.3390/neurolint14020029. PMID: 35466210
More publications by Alberto Benussi are available on the National Library of Medicine website.
Axel Montagne | 9th SCOR Young European Researcher Prize winner (2021)
- APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.
Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV.
Nature. 2020 May;581(7806):71-76. doi: 10.1038/s41586-020-2247-3. Epub 2020 Apr 29. PMID: 32376954 - Blood-Brain Barrier: From Physiology to Disease and Back.
Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV. - The role of brain vasculature in neurodegenerative disorders.
Sweeney MD, Kisler K, Montagne A, Toga AW, Zlokovic BV.
Nat Neurosci. 2018 Oct;21(10):1318-1331. doi: 10.1038/s41593-018-0234-x. Epub 2018 Sep 24. PMID: 30250261 - Vascular dysfunction-The disregarded partner of Alzheimer's disease.
Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Al-Shahi Salman R, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV.
Alzheimers Dement. 2019 Jan;15(1):158-167. doi: 10.1016/j.jalz.2018.07.222. PMID: 30642436 - Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease.
Kisler K, Nelson AR, Montagne A, Zlokovic BV.
Nat Rev Neurosci. 2017 Jul;18(7):419-434. doi: 10.1038/nrn.2017.48. Epub 2017 May 18. PMID: 28515434 - Blood-brain barrier breakdown in the aging human hippocampus.
Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV.
Neuron. 2015 Jan 21;85(2):296-302. doi: 10.1016/j.neuron.2014.12.032. PMID: 25611508 - APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β.
Montagne A, Nikolakopoulou AM, Huuskonen MT, Sagare AP, Lawson EJ, Lazic D, Rege SV, Grond A, Zuniga E, Barnes SR, Prince J, Sagare M, Hsu CJ, LaDu MJ, Jacobs RE, Zlokovic BV.
Nat Aging. 2021 Jun;1(6):506-520. doi: 10.1038/s43587-021-00073-z. Epub 2021 Jun 14. PMID: 35291561 - Alzheimer's disease: A matter of blood-brain barrier dysfunction?
Montagne A, Zhao Z, Zlokovic BV.
J Exp Med. 2017 Nov 6;214(11):3151-3169. doi: 10.1084/jem.20171406. Epub 2017 Oct 23. PMID: 29061693 - Alzheimer's pathogenic mechanisms and underlying sex difference.
Zhu D, Montagne A, Zhao Z.
Cell Mol Life Sci. 2021 Jun;78(11):4907-4920. doi: 10.1007/s00018-021-03830-w. Epub 2021 Apr 12. PMID: 33844047 - Magnetic Resonance Imaging of Blood-Brain Barrier permeability in Dementia.
Chagnot A, Barnes SR, Montagne A.
Neuroscience. 2021 Oct 15;474:14-29. doi: 10.1016/j.neuroscience.2021.08.003. Epub 2021 Aug 13. PMID: 34400249
More publications by Axel Montagne are available on the National Library of Medicine website.
Renzo Mancuso | 8th SCOR Young European Researcher Prize winner (2020)
- Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.
Chen WT, Lu A, Craessaerts K, Pavie B, Sala Frigerio C, Corthout N, Qian X, Laláková J, Kühnemund M, Voytyuk I, Wolfs L, Mancuso R, Salta E, Balusu S, Snellinx A, Munck S, Jurek A, Fernandez Navarro J, Saido TC, Huitinga I, Lundeberg J, Fiers M, De Strooper B. Cell.
2020 Aug 20;182(4):976-991.e19. doi: 10.1016/j.cell.2020.06.038. Epub 2020 Jul 22. PMID: 32702314 - Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Pasciuto E, Burton OT, Roca CP, Lagou V, Rajan WD, Theys T, Mancuso R, Tito RY, Kouser L, Callaerts-Vegh Z, de la Fuente AG, Prezzemolo T, Mascali LG, Brajic A, Whyte CE, Yshii L, Martinez-Muriana A, Naughton M, Young A, Moudra A, Lemaitre P, Poovathingal S, Raes J, De Strooper B, Fitzgerald DC, Dooley J, Liston A. Cell.
2020 Aug 6;182(3):625-640.e24. doi: 10.1016/j.cell.2020.06.026. Epub 2020 Jul 22. PMID: 32702313 Free PMC article. - Stem-cell-derived human microglia transplanted in mouse brain to study human disease.
Mancuso R, Van Den Daele J, Fattorelli N, Wolfs L, Balusu S, Burton O, Liston A, Sierksma A, Fourne Y, Poovathingal S, Arranz-Mendiguren A, Sala Frigerio C, Claes C, Serneels L, Theys T, Perry VH, Verfaillie C, Fiers M, De Strooper B. Nat Neurosci.
2019 Dec;22(12):2111-2116. doi: 10.1038/s41593-019-0525-x. Epub 2019 Oct 28. PMID: 31659342 - The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.
Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, Hyman B, Perry VH, Fiers M, De Strooper B. Cell Rep.
2019 Apr 23;27(4):1293-1306.e6. doi: 10.1016/j.celrep.2019.03.099. PMID: 31018141 Free PMC article. - Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology.
Sierksma A, Lu A, Mancuso R, Fattorelli N, Thrupp N, Salta E, Zoco J, Blum D, Buée L, De Strooper B, Fiers M. EMBO Mol Med.
2020 Mar 6;12(3):e10606. doi: 10.15252/emmm.201910606. Epub 2020 Jan 17. PMID: 31951107 Free PMC article. - Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans.
Thrupp N, Sala Frigerio C, Wolfs L, Skene NG, Fattorelli N, Poovathingal S, Fourne Y, Matthews PM, Theys T, Mancuso R, de Strooper B, Fiers M. Cell Rep.
2020 Sep 29;32(13):108189. doi: 10.1016/j.celrep.2020.108189. PMID: 32997994 Free PMC article. - CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón-Sandoval J, Ribe E, Winchester L, Webber C, Nevado A, Jacobs T, Austin N, Theunis C, Grauwen K, Daniela Ruiz E, Mudher A, Vicente-Rodriguez M, Parker CA, Simmons C, Cash D, Richardson J; NIMA Consortium, Jones DNC, Lovestone S, Gómez-Nicola D, Perry VH. Brain.
2019 Oct 1;142(10):3243-3264. doi: 10.1093/brain/awz241. PMID: 31504240 Free PMC article. - Inflammatory biomarkers in Alzheimer's disease plasma.
Morgan AR, Touchard S, Leckey C, O'Hagan C, Nevado-Holgado AJ; NIMA Consortium, Barkhof F, Bertram L, Blin O, Bos I, Dobricic V, Engelborghs S, Frisoni G, Frölich L, Gabel S, Johannsen P, Kettunen P, Kłoszewska I, Legido-Quigley C, Lleó A, Martinez-Lage P, Mecocci P, Meersmans K, Molinuevo JL, Peyratout G, Popp J, Richardson J, Sala I, Scheltens P, Streffer J, Soininen H, Tainta-Cuezva M, Teunissen C, Tsolaki M, Vandenberghe R, Visser PJ, Vos S, Wahlund LO, Wallin A, Westwood S, Zetterberg H, Lovestone S, Morgan BP; Annex: NIMA–Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer's Disease. Alzheimers Dement.
2019 Jun;15(6):776-787. doi: 10.1016/j.jalz.2019.03.007. Epub 2019 Apr 30. PMID: 31047856 Free PMC article. - Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology.
Olmos-Alonso A, Schetters ST, Sri S, Askew K, Mancuso R, Vargas-Caballero M, Holscher C, Perry VH, Gomez-Nicola D. Brain.
2016 Mar;139(Pt 3):891-907. doi: 10.1093/brain/awv379. Epub 2016 Jan 8. PMID: 26747862 Free PMC article. - Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1G93A mice.
Martínez-Muriana A, Pastor D, Mancuso R, Rando A, Osta R, Martínez S, López-Vales R, Navarro X. Stem Cell Res Ther.
2020 Feb 7;11(1):53. doi: 10.1186/s13287-020-1573-6. PMID: 32033585 Free PMC article.
More publications by Renzo Mancuso are available on the National Library of Medicine website.
Federica Agosta | 7th SCOR Young European Researcher Prize winner (2019)
- Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias.
Chételat G, Arbizu J, Barthel H, Garibotto V, Law I, Morbelli S, van de Giessen E, Agosta F, Barkhof F, Brooks DJ, Carrillo MC, Dubois B, Fjell AM, Frisoni GB, Hansson O, Herholz K, Hutton BF, Jack CR Jr, Lammertsma AA, Landau SM, Minoshima S, Nobili F, Nordberg A, Ossenkoppele R, Oyen WJG, Perani D, Rabinovici GD, Scheltens P, Villemagne VL, Zetterberg H, Drzezga A. Lancet Neurol.
2020 Nov;19(11):951-962. doi: 10.1016/S1474-4422(20)30314-8. PMID: 33098804 Review. - MRI of Motor and Nonmotor Therapy-Induced Complications in Parkinson's Disease.
Donzuso G, Agosta F, Canu E, Filippi M. Mov Disord.
2020 May;35(5):724-740. doi: 10.1002/mds.28025. Epub 2020 Mar 17. PMID: 32181946 Review - Deep learning: a turning point in acute neurology.
Filippi M, Cividini C, Agosta F. Lancet Digit Health. 2020 Jun;2(6):e273-e274. doi: 10.1016/S2589-7500(20)30106-0. Epub
2020 May 14. PMID: 33328119 No abstract available - Functional brain connectome in posterior cortical atrophy.
Migliaccio R, Agosta F, Basaia S, Cividini C, Habert MO, Kas A, Montembeault M, Filippi M. Neuroimage Clin.
2020;25:102100. doi: 10.1016/j.nicl.2019.102100. Epub 2019 Nov 20. PMID: 31865020 Free PMC article - Focus on the heterogeneity of amyotrophic lateral sclerosis.
Bendotti C, Bonetto V, Pupillo E, Logroscino G, Al-Chalabi A, Lunetta C, Riva N, Mora G, Lauria G, Weishaupt JH, Agosta F, Malaspina A, Basso M, Greensmith L, Van Den Bosch L, Ratti A, Corbo M, Hardiman O, Chiò A, Silani V, Beghi E. Amyotroph Lateral Scler Frontotemporal Degener.
2020 Nov;21(7-8):485-495. doi: 10.1080/21678421.2020.1779298. Epub 2020 Jun 25. PMID: 32583689 - Amyloid-Related Imaging Abnormalities and β-Amyloid-Targeting Antibodies: A Systematic Review.
Filippi M, Cecchetti G, Spinelli EG, Vezzulli P, Falini A, Agosta F.
JAMA Neurol. 2022 Mar 1;79(3):291-304. doi: 10.1001/jamaneurol.2021.5205. PMID: 35099507 Review. - Automated classification of Alzheimer's disease and mild cognitive impairment using a single MRI and deep neural networks.
Basaia S, Agosta F, Wagner L, Canu E, Magnani G, Santangelo R, Filippi M; Alzheimer's Disease Neuroimaging Initiative.
Neuroimage Clin. 2019;21:101645. doi: 10.1016/j.nicl.2018.101645. Epub 2018 Dec 18. PMID: 30584016 - MRI of non-Alzheimer's dementia: current and emerging knowledge.
Filippi M, Agosta F.
Curr Opin Neurol. 2018 Aug;31(4):405-414. doi: 10.1097/WCO.0000000000000571. PMID: 29746400 Review. - Perspectives and challenges in patient stratification in Alzheimer's disease.
Abdelnour C, Agosta F, Bozzali M, Fougère B, Iwata A, Nilforooshan R, Takada LT, Viñuela F, Traber M.
Alzheimers Res Ther. 2022 Aug 13;14(1):112. doi: 10.1186/s13195-022-01055-y. PMID: 35964143 - Natural Speech Analysis: A Window Into Alzheimer Disease Phenotypes.
Agosta F, Filippi M.
Neurology. 2022 Jul 26;99(4):137-138. doi: 10.1212/WNL.0000000000200843. Epub 2022 May 4. PMID: 35508400
More publications by Federica Agosta are available on the National Library of Medicine website.
Rik Ossenkoppele | 6th SCOR Young European Researcher Prize winner (2018)
- Amyloid-β-independent regulators of tau pathology in Alzheimer disease.
van der Kant R, Goldstein LSB, Ossenkoppele R. Nat Rev Neurosci.
2020 Jan;21(1):21-35. doi: 10.1038/s41583-019-0240-3. Epub 2019 Nov 28. PMID: 31780819 Review. - Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias.
Chételat G, Arbizu J, Barthel H, Garibotto V, Law I, Morbelli S, van de Giessen E, Agosta F, Barkhof F, Brooks DJ, Carrillo MC, Dubois B, Fjell AM, Frisoni GB, Hansson O, Herholz K, Hutton BF, Jack CR Jr, Lammertsma AA, Landau SM, Minoshima S, Nobili F, Nordberg A, Ossenkoppele R, Oyen WJG, Perani D, Rabinovici GD, Scheltens P, Villemagne VL, Zetterberg H, Drzezga A. Lancet Neurol.
2020 Nov;19(11):951-962. doi: 10.1016/S1474-4422(20)30314-8. PMID: 33098804 Review. - Clinicopathological correlations in behavioural variant frontotemporal dementia.
Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW. Brain.
2017 Dec 1;140(12):3329-3345. doi: 10.1093/brain/awx254. PMID: 29053860 Free PMC article. - The effect of physical activity on cognitive function in patients with dementia: A meta-analysis of randomized control trials.
Groot C, Hooghiemstra AM, Raijmakers PG, van Berckel BN, Scheltens P, Scherder EJ, van der Flier WM, Ossenkoppele R.
Ageing Res Rev. 2016 Jan;25:13-23. doi: 10.1016/j.arr.2015.11.005. Epub 2015 Nov 28. PMID: 26607411 Review. - Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
Jansen WJ, Ossenkoppele R, Knol DL, Tijms BM, Scheltens P, Verhey FR, Visser PJ; Amyloid Biomarker Study Group, Aalten P, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BN, Bibeau K, Blennow K, Brooks DJ, van Buchem MA, Camus V, Cavedo E, Chen K, Chetelat G, Cohen AD, Drzezga A, Engelborghs S, Fagan AM, Fladby T, Fleisher AS, van der Flier WM, Ford L, Förster S, Fortea J, Foskett N, Frederiksen KS, Freund-Levi Y, Frisoni GB, Froelich L, Gabryelewicz T, Gill KD, Gkatzima O, Gómez-Tortosa E, Gordon MF, Grimmer T, Hampel H, Hausner L, Hellwig S, Herukka SK, Hildebrandt H, Ishihara L, Ivanoiu A, Jagust WJ, Johannsen P, Kandimalla R, Kapaki E, Klimkowicz-Mrowiec A, Klunk WE, Köhler S, Koglin N, Kornhuber J, Kramberger MG, Van Laere K, Landau SM, Lee DY, de Leon M, Lisetti V, Lleó A, Madsen K, Maier W, Marcusson J, Mattsson N, de Mendonça A, Meulenbroek O, Meyer PT, Mintun MA, Mok V, Molinuevo JL, Møllergård HM, Morris JC, Mroczko B, Van der Mussele S, Na DL, Newberg A, Nordberg A, Nordlund A, Novak GP, Paraskevas GP, Parnetti L, Perera G, Peters O, Popp J, Prabhakar S, Rabinovici GD, Ramakers IH, Rami L, Resende de Oliveira C, Rinne JO, Rodrigue KM, Rodríguez-Rodríguez E, Roe CM, Rot U, Rowe CC, Rüther E, Sabri O, Sanchez-Juan P, Santana I, Sarazin M, Schröder J, Schütte C, Seo SW, Soetewey F, Soininen H, Spiru L, Struyfs H, Teunissen CE, Tsolaki M, Vandenberghe R, Verbeek MM, Villemagne VL, Vos SJ, van Waalwijk van Doorn LJ, Waldemar G, Wallin A, Wallin ÅK, Wiltfang J, Wolk DA, Zboch M, Zetterberg H. JAMA.
2015 May 19;313(19):1924-38. doi: 10.1001/jama.2015.4668. PMID: 25988462 Free PMC article. - Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease.
Franzmeier N, Neitzel J, Rubinski A, Smith R, Strandberg O, Ossenkoppele R, Hansson O, Ewers M; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Nat Commun.
2020 Jan 17;11(1):347. doi: 10.1038/s41467-019-14159-1. PMID: 31953405 Free PMC article. - PET Imaging of Tau Deposition in the Aging Human Brain.
Schöll M, Lockhart SN, Schonhaut DR, O'Neil JP, Janabi M, Ossenkoppele R, Baker SL, Vogel JW, Faria J, Schwimmer HD, Rabinovici GD, Jagust WJ. Neuron.
2016 Mar 2;89(5):971-982. doi: 10.1016/j.neuron.2016.01.028. PMID: 26938442 Free PMC article. - The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features.
Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, La Joie R, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel BN, Miller BL, Barkhof F, Jagust WJ, Scheltens P, Seeley WW, Rabinovici GD. Brain.
2015 Sep;138(Pt 9):2732-49. doi: 10.1093/brain/awv191. Epub 2015 Jul 2. PMID: 26141491 Free PMC article. - Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship.
van Loenhoud AC, van der Flier WM, Wink AM, Dicks E, Groot C, Twisk J, Barkhof F, Scheltens P, Ossenkoppele R; Alzheimer's Disease Neuroimaging Initiative. Neurology.
2019 Jul 23;93(4):e334-e346. doi: 10.1212/WNL.0000000000007821. Epub 2019 Jul 2. PMID: 31266904 Free PMC article. - Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.
Bergeron D, Gorno-Tempini ML, Rabinovici GD, Santos-Santos MA, Seeley W, Miller BL, Pijnenburg Y, Keulen MA, Groot C, van Berckel BNM, van der Flier WM, Scheltens P, Rohrer JD, Warren JD, Schott JM, Fox NC, Sanchez-Valle R, Grau-Rivera O, Gelpi E, Seelaar H, Papma JM, van Swieten JC, Hodges JR, Leyton CE, Piguet O, Rogalski EJ, Mesulam MM, Koric L, Nora K, Pariente J, Dickerson B, Mackenzie IR, Hsiung GR, Belliard S, Irwin DJ, Wolk DA, Grossman M, Jones M, Harris J, Mann D, Snowden JS, Chrem-Mendez P, Calandri IL, Amengual AA, Miguet-Alfonsi C, Magnin E, Magnani G, Santangelo R, Deramecourt V, Pasquier F, Mattsson N, Nilsson C, Hansson O, Keith J, Masellis M, Black SE, Matías-Guiu JA, Cabrera-Martin MN, Paquet C, Dumurgier J, Teichmann M, Sarazin M, Bottlaender M, Dubois B, Rowe CC, Villemagne VL, Vandenberghe R, Granadillo E, Teng E, Mendez M, Meyer PT, Frings L, Lleó A, Blesa R, Fortea J, Seo SW, Diehl-Schmid J, Grimmer T, Frederiksen KS, Sánchez-Juan P, Chételat G, Jansen W, Bouchard RW, Laforce RJ, Visser PJ, Ossenkoppele R. Ann Neurol.
2018 Nov;84(5):729-740. doi: 10.1002/ana.25333. PMID: 30255971 Free PMC article.
More publications by Rik Ossenkoppele are available on the National Library of Medicine website.
Erick Portelius | 5th SCOR Young European Researcher Prize winner (2017)
- Quantification of total apolipoprotein E and its isoforms in cerebrospinal fluid from patients with neurodegenerative diseases.
Minta K, Brinkmalm G, Janelidze S, Sjödin S, Portelius E, Stomrud E, Zetterberg H, Blennow K, Hansson O, Andreasson U. Alzheimers Res Ther.
2020 Feb 13;12(1):19. doi: 10.1186/s13195-020-00585-7. PMID: 32054532 Free PMC article - Perspectives in fluid biomarkers in neurodegeneration from the 2019 biomarkers in neurodegenerative diseases course-a joint PhD student course at University College London and University of Gothenburg.
Obrocki P, Khatun A, Ness D, Senkevich K, Hanrieder J, Capraro F, Mattsson N, Andreasson U, Portelius E, Ashton NJ, Blennow K, Schöll M, Paterson RW, Schott JM, Zetterberg H. Alzheimers Res Ther.
2020 Feb 28;12(1):20. doi: 10.1186/s13195-020-00586-6. PMID: 32111242 Free PMC article. Review - Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders.
Olsson B, Portelius E, Cullen NC, Sandelius Å, Zetterberg H, Andreasson U, Höglund K, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk D, McCluskey L, Elman L, Shaw LM, Toledo JB, McBride J, Hernandez-Con P, Lee VM, Trojanowski JQ, Blennow K. JAMA Neurol.
2019 Mar 1;76(3):318-325. doi: 10.1001/jamaneurol.2018.3746. - Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology.
Blennow K, Chen C, Cicognola C, Wildsmith KR, Manser PT, Bohorquez SMS, Zhang Z, Xie B, Peng J, Hansson O, Kvartsberg H, Portelius E, Zetterberg H, Lashley T, Brinkmalm G, Kerchner GA, Weimer RM, Ye K, Höglund K. Brain.
2020 Feb 1;143(2):650-660. doi: 10.1093/brain/awz346. PMID: 31834365 - Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
Alić I, Goh PA, Murray A, Portelius E, Gkanatsiou E, Gough G, Mok KY, Koschut D, Brunmeir R, Yeap YJ, O'Brien NL, Groet J, Shao X, Havlicek S, Dunn NR, Kvartsberg H, Brinkmalm G, Hithersay R, Startin C, Hamburg S, Phillips M, Pervushin K, Turmaine M, Wallon D, Rovelet-Lecrux A, Soininen H, Volpi E, Martin JE, Foo JN, Becker DL, Rostagno A, Ghiso J, Krsnik Ž, Šimić G, Kostović I, Mitrečić D; LonDownS Consortium, Francis PT, Blennow K, Strydom A, Hardy J, Zetterberg H, Nižetić D. Mol Psychiatry.
2020 Jul 10. doi: 10.1038/s41380-020-0806-5. Online ahead of print. PMID: 32647257 - Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease.
Cicognola C, Brinkmalm G, Wahlgren J, Portelius E, Gobom J, Cullen NC, Hansson O, Parnetti L, Constantinescu R, Wildsmith K, Chen HH, Beach TG, Lashley T, Zetterberg H, Blennow K, Höglund K. Acta Neuropathol.
2019 Feb;137(2):279-296. doi: 10.1007/s00401-018-1948-2. Epub 2018 Dec 13. PMID: 30547227 Free PMC article - Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease.
Cicognola C, Brinkmalm G, Wahlgren J, Portelius E, Gobom J, Cullen NC, Hansson O, Parnetti L, Constantinescu R, Wildsmith K, Chen HH, Beach TG, Lashley T, Zetterberg H, Blennow K, Höglund K. Acta Neuropathol.
2019 Feb;137(2):279-296. doi: 10.1007/s00401-018-1948-2. Epub 2018 Dec 13. PMID: 30547227 Free PMC article - First amyloid β1-42 certified reference material for re-calibrating commercial immunoassays.
Boulo S, Kuhlmann J, Andreasson U, Brix B, Venkataraman I, Herbst V, Rutz S, Manuilova E, Vandijck M, Dekeyser F, Bjerke M, Pannee J, Charoud-Got J, Auclair G, Mazoua S, Pinski G, Trapmann S, Schimmel H, Emons H, Quaglia M, Portelius E, Korecka M, Shaw LM, Lame M, Chambers E, Vanderstichele H, Stoops E, Leinenbach A, Bittner T, Jenkins RG, Kostanjevecki V, Lewczuk P, Gobom J, Zetterberg H, Zegers I, Blennow K. Alzheimers Dement.
2020 Nov;16(11):1493-1503. doi: 10.1002/alz.12145. Epub 2020 Aug 4. PMID: 3275501 - Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain.
Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM. Brain.
2019 May 1;142(5):1441-1457. doi: 10.1093/brain/awz066. PMID: 31032851 Free PMC article - First amyloid β1-42 certified reference material for re-calibrating commercial immunoassays.
Boulo S, Kuhlmann J, Andreasson U, Brix B, Venkataraman I, Herbst V, Rutz S, Manuilova E, Vandijck M, Dekeyser F, Bjerke M, Pannee J, Charoud-Got J, Auclair G, Mazoua S, Pinski G, Trapmann S, Schimmel H, Emons H, Quaglia M, Portelius E, Korecka M, Shaw LM, Lame M, Chambers E, Vanderstichele H, Stoops
E, Leinenbach A, Bittner T, Jenkins RG, Kostanjevecki V, Lewczuk P, Gobom J, Zetterberg H, Zegers I, Blennow K. Alzheimers Dement. 2020 Nov;16(11):1493-1503. doi: 10.1002/alz.12145. Epub 2020 Aug 4. PMID: 32755010
More publications by Erik Portelius are available on the National Library of Medicine website.
Niklas Mattsson | 4th SCOR Young European Researcher Prize winner (2016)
- Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts.
Karikari TK, Pascoal TA, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, Chamoun M, Savard M, Kang MS, Therriault J, Schöll M, Massarweh G, Soucy JP, Höglund K, Brinkmalm G, Mattsson N, Palmqvist S, Gauthier S, Stomrud E, Zetterberg H, Hansson O, Rosa-Neto P, Blennow K. Lancet Neurol.
2020 May;19(5):422-433. doi: 10.1016/S1474-4422(20)30071-5. PMID: 32333900 - Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer's disease.
Whelan CD, Mattsson N, Nagle MW, Vijayaraghavan S, Hyde C, Janelidze S, Stomrud E, Lee J, Fitz L, Samad TA, Ramaswamy G, Margolin RA, Malarstig A, Hansson O. Acta Neuropathol Commun.
2019 Nov 6;7(1):169. doi: 10.1186/s40478-019-0795-2. PMID: 31694701 Free PMC article. - Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia.
Janelidze S, Mattsson N, Palmqvist S, Smith R, Beach TG, Serrano GE, Chai X, Proctor NK, Eichenlaub U, Zetterberg H, Blennow K, Reiman EM, Stomrud E, Dage JL, Hansson O. Nat Med.
2020 Mar;26(3):379-386. doi: 10.1038/s41591-020-0755-1. Epub 2020 Mar 2. PMID: 32123385 - Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease.
Mattsson N, Cullen NC, Andreasson U, Zetterberg H, Blennow K. JAMA Neurol.
2019 Jul 1;76(7):791-799. doi: 10.1001/jamaneurol.2019.0765. PMID: 31009028 Free PMC article. - Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.
Bridel C, van Wieringen WN, Zetterberg H, Tijms BM, Teunissen CE; and the NFL Group, Alvarez-Cermeño JC, Andreasson U, Axelsson M, Bäckström DC, Bartos A, Bjerke M, Blennow K, Boxer A, Brundin L, Burman J, Christensen T, Fialová L, Forsgren L, Frederiksen JL, Gisslén M, Gray E, Gunnarsson M, Hall S, Hansson O, Herbert MK, Jakobsson J, Jessen-Krut J, Janelidze S, Johannsson G, Jonsson M, Kappos L, Khademi M, Khalil M, Kuhle J, Landén M, Leinonen V, Logroscino G, Lu CH, Lycke J, Magdalinou NK, Malaspina A, Mattsson N, Meeter LH, Mehta SR, Modvig S, Olsson T, Paterson RW, Pérez-Santiago J, Piehl F, Pijnenburg YAL, Pyykkö OT, Ragnarsson O, Rojas JC, Romme Christensen J, Sandberg L, Scherling CS, Schott JM, Sellebjerg FT, Simone IL, Skillbäck T, Stilund M, Sundström P, Svenningsson A, Tortelli R, Tortorella C, Trentini A, Troiano M, Turner MR, van Swieten JC, Vågberg M, Verbeek MM, Villar LM, Visser PJ, Wallin A, Weiss A, Wikkelsø C, Wild EJ. JAMA Neurol.
2019 Jun 17;76(9):1035-48. doi: 10.1001/jamaneurol.2019.1534. Online ahead of print. PMID: 31206160 Free PMC article. - Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease.
Palmqvist S, Insel PS, Stomrud E, Janelidze S, Zetterberg H, Brix B, Eichenlaub U, Dage JL, Chai X, Blennow K, Mattsson N, Hansson O. EMBO Mol Med.
2019 Dec;11(12):e11170. doi: 10.15252/emmm.201911170. Epub 2019 Nov 11. PMID: 31709776 Free PMC article. - Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease.
Janelidze S, Stomrud E, Smith R, Palmqvist S, Mattsson N, Airey DC, Proctor NK, Chai X, Shcherbinin S, Sims JR, Triana-Baltzer G, Theunis C, Slemmon R, Mercken M, Kolb H, Dage JL, Hansson O. Nat Commun.
2020 Apr 3;11(1):1683. doi: 10.1038/s41467-020-15436-0. PMID: 32246036 Free PMC article. - Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease.
Mattsson N, Andreasson U, Zetterberg H, Blennow K; Alzheimer’s Disease Neuroimaging Initiative. JAMA Neurol.
2017 May 1;74(5):557-566. doi: 10.1001/jamaneurol.2016.6117. PMID: 28346578 Free PMC article. - Biomarkers for tau pathology.
Schöll M, Maass A, Mattsson N, Ashton NJ, Blennow K, Zetterberg H, Jagust W. Mol Cell Neurosci.
2019 Jun;97:18-33. doi: 10.1016/j.mcn.2018.12.001. Epub 2018 Dec 7. PMID: 30529601 Free PMC article. Review. - Performance of Fully Automated Plasma Assays as Screening Tests for Alzheimer Disease-Related β-Amyloid Status.
Palmqvist S, Janelidze S, Stomrud E, Zetterberg H, Karl J, Zink K, Bittner T, Mattsson N, Eichenlaub U, Blennow K, Hansson O. JAMA Neurol.
2019 Jun 24;76(9):1060-9. doi: 10.1001/jamaneurol.2019.1632. Online ahead of print. PMID: 31233127 Free PMC article.
More publications by Niklas Mattsson are available on the National Library of Medicine website.
Lawrence Rajendran | 3rd SCOR Young European Researcher Prize winner (2015)
- Microglia-Mediated Synapse Loss in Alzheimer's Disease.
Rajendran L, Paolicelli RC.
J Neurosci. 2018 Mar 21;38(12):2911-2919. doi: 10.1523/JNEUROSCI.1136-17.2017. PMID: 29563239 - The Alzheimer's Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides.
Siegel G, Gerber H, Koch P, Bruestle O, Fraering PC, Rajendran L.
Cell Rep. 2017 Jun 6;19(10):1967-1976. doi: 10.1016/j.celrep.2017.05.034. PMID: 28591569 - Retromers in Alzheimer's disease.
Siegenthaler BM, Rajendran L.
Neurodegener Dis. 2012;10(1-4):116-21. doi: 10.1159/000335910. Epub 2012 Mar 3. PMID: 22398391 - Membrane trafficking pathways in Alzheimer's disease.
Rajendran L, Annaert W.
Traffic. 2012 Jun;13(6):759-70. doi: 10.1111/j.1600-0854.2012.01332.x. Epub 2012 Feb 17. PMID: 22269004 - Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein.
Ben Halima S, Mishra S, Raja KMP, Willem M, Baici A, Simons K, Brüstle O, Koch P, Haass C, Caflisch A, Rajendran L.
Cell Rep. 2016 Mar 8;14(9):2127-2141. doi: 10.1016/j.celrep.2016.01.076. Epub 2016 Feb 25. PMID: 26923602 - Exploration of Plasma Lipids in Mild Cognitive Impairment due to Alzheimer's Disease.
Bergland AK, Proitsi P, Kirsebom BE, Soennesyn H, Hye A, Larsen AI, Xu J, Legido-Quigley C, Rajendran L, Fladby T, Aarsland D.
J Alzheimers Dis. 2020;77(3):1117-1127. doi: 10.3233/JAD-200441. PMID: 32804144 - miR-186 in Alzheimer's disease: a big hope for a small RNA?
Ben Halima S, Siegel G, Rajendran L.
J Neurochem. 2016 May;137(3):308-11. doi: 10.1111/jnc.13573. Epub 2016 Mar 30. PMID: 27029568 - Why does the Aβ peptide of Alzheimer share structural similarity with antimicrobial peptides?
Pastore A, Raimondi F, Rajendran L, Temussi PA.
Commun Biol. 2020 Mar 19;3(1):135. doi: 10.1038/s42003-020-0865-9. PMID: 32193491 - Cellular basis of Alzheimer's disease.
Bali J, Halima SB, Felmy B, Goodger Z, Zurbriggen S, Rajendran L.
Ann Indian Acad Neurol. 2010 Dec;13(Suppl 2):S89-93. doi: 10.4103/0972-2327.74251. PMID: 21369424 - Membrane anchored and lipid raft targeted β-secretase inhibitors for Alzheimer's disease therapy.
Ben Halima S, Rajendran L.
J Alzheimers Dis. 2011;24 Suppl 2:143-52. doi: 10.3233/JAD-2011-110269. PMID: 21460437
More publications by Lawrence Rajendran are available on the National Library of Medicine website.
Rita Guerreiro | 2nd SCOR Young European Researcher Prize winner (2014)
- The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders.
Carmona S, Zahs K, Wu E, Dakin K, Bras J, Guerreiro R.
Lancet Neurol. 2018 Aug;17(8):721-730. doi: 10.1016/S1474-4422(18)30232-1. Epub 2018 Jul 17. PMID: 30033062 Review. - TREM2 variants in Alzheimer's disease.
Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J; Alzheimer Genetic Analysis Group.
N Engl J Med. 2013 Jan 10;368(2):117-27. doi: 10.1056/NEJMoa1211851. Epub 2012 Nov 14. PMID: 23150934 - Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease.
Holstege H, Hulsman M, Charbonnier C, Grenier-Boley B, Quenez O, Grozeva D, van Rooij JGJ, Sims R, Ahmad S, Amin N, Norsworthy PJ, Dols-Icardo O, Hummerich H, Kawalia A, Amouyel P, Beecham GW, Berr C, Bis JC, Boland A, Bossù P, Bouwman F, Bras J, Campion D, Cochran JN, Daniele A, Dartigues JF, Debette S, Deleuze JF, Denning N, DeStefano AL, Farrer LA, Fernández MV, Fox NC, Galimberti D, Genin E, Gille JJP, Le Guen Y, Guerreiro R, Haines JL, Holmes C, Ikram MA, Ikram MK, Jansen IE, Kraaij R, Lathrop M, Lemstra AW, Lleó A, Luckcuck L, Mannens MMAM, Marshall R, Martin ER, Masullo C, Mayeux R, Mecocci P, Meggy A, Mol MO, Morgan K, Myers RM, Nacmias B, Naj AC, Napolioni V, Pasquier F, Pastor P, Pericak-Vance MA, Raybould R, Redon R, Reinders MJT, Richard AC, Riedel-Heller SG, Rivadeneira F, Rousseau S, Ryan NS, Saad S, Sanchez-Juan P, Schellenberg GD, Scheltens P, Schott JM, Seripa D, Seshadri S, Sie D, Sistermans EA, Sorbi S, van Spaendonk R, Spalletta G, Tesi N, Tijms B, Uitterlinden AG, van der Lee SJ, Visser PJ, Wagner M, Wallon D, Wang LS, Zarea A, Clarimon J, van Swieten JC, Greicius MD, Yokoyama JS, Cruchaga C, Hardy J, Ramirez A, Mead S, van der Flier WM, van Duijn CM, W…
Nat Genet. 2022 Dec;54(12):1786-1794. doi: 10.1038/s41588-022-01208-7. Epub 2022 Nov 21. PMID: 36411364 - Challenge accepted: uncovering the role of rare genetic variants in Alzheimer's disease.
Khani M, Gibbons E, Bras J, Guerreiro R.
Mol Neurodegener. 2022 Jan 9;17(1):3. doi: 10.1186/s13024-021-00505-9. PMID: 35000612 - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J.
Nat Genet. 2009 Oct;41(10):1088-93. doi: 10.1038/ng.440. Epub 2009 Sep 6. PMID: 19734902 - Genetics of Alzheimer's disease.
Guerreiro R, Hardy J.
Neurotherapeutics. 2014 Oct;11(4):732-7. doi: 10.1007/s13311-014-0295-9. PMID: 25113539 - Genetic architecture of common non-Alzheimer's disease dementias.
Guerreiro R, Gibbons E, Tábuas-Pereira M, Kun-Rodrigues C, Santo GC, Bras J.
Neurobiol Dis. 2020 Aug;142:104946. doi: 10.1016/j.nbd.2020.104946. Epub 2020 May 19. PMID: 32439597 - How understudied populations have contributed to our understanding of Alzheimer's disease genetics.
Dehghani N, Bras J, Guerreiro R.
Brain. 2021 May 7;144(4):1067-1081. doi: 10.1093/brain/awab028. PMID: 33889936 - Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease.
Guerreiro R, Bras J, Toombs J, Heslegrave A, Hardy J, Zetterberg H.
Curr Genet Med Rep. 2015;3(1):19-25. doi: 10.1007/s40142-014-0062-6. PMID: 25664224 - Complement receptor 1 (CR1) and Alzheimer's disease.
Crehan H, Holton P, Wray S, Pocock J, Guerreiro R, Hardy J.
Immunobiology. 2012 Feb;217(2):244-50. doi: 10.1016/j.imbio.2011.07.017. Epub 2011 Jul 23. PMID: 21840620
More publications by Rita Guerreiro are available on the National Library of Medicine website.
Florence Clavaguera | 1st SCOR Young European Researcher Prize winner (2013)
- Transmission and spreading of tauopathy in transgenic mouse brain
Florence Clavaguera, Tristan Bolmont, R Anthony Crowther, Dorothee Abramowski, Stephan Frank, Alphonse Probst, Graham Fraser, Anna K Stalder, Martin Beibel, Matthias Staufenbiel, Mathias Jucker, Michel Goedert, Markus Tolnay
Nat Cell Biol. 2009 Jul;11(7):909-13. doi: 10.1038/ncb1901. Epub 2009 Jun 7. PMID: 19503072 - Invited review: Prion-like transmission and spreading of tau pathology.
Clavaguera F, Hench J, Goedert M, Tolnay M.
Neuropathol Appl Neurobiol. 2015 Feb;41(1):47-58. doi: 10.1111/nan.12197. PMID: 25399729 Review. - Co-expression of truncated and full-length tau induces severe neurotoxicity.
Ozcelik S, Sprenger F, Skachokova Z, Fraser G, Abramowski D, Clavaguera F, Probst A, Frank S, Müller M, Staufenbiel M, Goedert M, Tolnay M, Winkler DT.
Mol Psychiatry. 2016 Dec;21(12):1790-1798. doi: 10.1038/mp.2015.228. Epub 2016 Feb 2. PMID: 26830137 - Tauopathy models and human neuropathology: similarities and differences.
Frank S, Clavaguera F, Tolnay M.
Acta Neuropathol. 2008 Jan;115(1):39-53. doi: 10.1007/s00401-007-0291-9. Epub 2007 Sep 5. PMID: 17786456 - [Induction and spreading of tau pathology in a mouse model of Alzheimer's disease].
Clavaguera F, Goedert M, Tolnay M.
Med Sci (Paris). 2010 Feb;26(2):121-4. doi: 10.1051/medsci/2010262121. PMID: 20188034 - Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.
Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K, Clavaguera F, Sinnreich M, Kappos L, Goedert M, Tolnay M, Winkler DT.
PLoS One. 2013 May 7;8(5):e62459. doi: 10.1371/journal.pone.0062459. Print 2013. PMID: 23667480 - Brain homogenates from human tauopathies induce tau inclusions in mouse brain.
Clavaguera F, Akatsu H, Fraser G, Crowther RA, Frank S, Hench J, Probst A, Winkler DT, Reichwald J, Staufenbiel M, Ghetti B, Goedert M, Tolnay M.
Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9535-40. doi: 10.1073/pnas.1301175110. Epub 2013 May 20. PMID: 23690619 - Intercellular transfer of tau aggregates and spreading of tau pathology: Implications for therapeutic strategies
Clavaguera F, Grueninger F, Tolnay M.
Neuropharmacology. 2014 Jan;76 Pt A:9-15. doi: 10.1016/j.neuropharm.2013.08.037. Epub 2013 Sep 17. PMID: 24050961 - Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice.
Clavaguera F, Hench J, Lavenir I, Schweighauser G, Frank S, Goedert M, Tolnay M.
Acta Neuropathol. 2014 Feb;127(2):299-301. doi: 10.1007/s00401-013-1231-5. Epub 2013 Dec 21. PMID: 24362441 - The Prion-Like Behavior of Assembled Tau in Transgenic Mice.
Clavaguera F, Tolnay M, Goedert M.
Cold Spring Harb Perspect Med. 2017 Oct 3;7(10):a024372. doi: 10.1101/cshperspect.a024372. PMID: 27940600
More publications by Florence Clavaguera are available on the National Library of Medicine website.
