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SCOR Young European Researcher Prize for research into Alzheimer’s disease

SCOR Young European Researcher Prize for research into Alzheimer’s disease

The SCOR Corporate Foundation for Science is proud to support France’s Alzheimer’s Research Foundation through this SCOR Young European Researcher Prize.


Extending and reinforcing a partnership initiated by SCOR in 2008, the SCOR Corporate Foundation for Science signed a sponsorship agreement with the research program of France’s Alzheimer’s Research Foundation (Fondation Recherche Alzheimer) on June 12, 2013. As well as creating an annual award for young European researchers, the agreement enables the Research Foundation to continue observing a cohort of patients as part of a long-term study of Alzheimer’s sufferers, and to promote cooperative research in this field with scientists from other countries.


Axel Montagne, winner of the 2021 European Young Researcher Award-SCOR




Meet the prizewinners

SCOR Foundation + Fondation Recherche Alzheimer



Alberto Benussi
Alberto Benussi

The 2022 SCOR Young European Researcher Prize for research into Alzheimer’s disease was awarded to neurologist Dr Alberto Benussi, 36, currently Assistant Professor of Neurology at Brescia Hospital (Italy) where he heads the center for cognitive disorders. Professor Alberto Benussi completed his training in Rome (lRCCS in Santa Lucia), and then in London (Queen Square Institute of Neurology). His innovative work focuses on non-invasive brain stimulation methods that may benefit patients suffering from neurodegenerative diseases.
He is currently looking to develop a device that could be used at home to assess the cognitive benefits of long-term stimulation (repeated low-intensity transcranial electrical stimulation).

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Axel Montagne
Axel Montagne

French researcher Axel Montagne won the award for his research on how cerebrovascular dysfunction contributes to neurodegeneration and cognitive impairment in animal models and humans. In the context of neurodegenerative diseases, he studies the causes and effects of dysfunction of the blood-brain barrier, the main function of which is to isolate the central nervous system from the bloodstream, preventing potentially toxic foreign substances from entering the brain.
Axel Montagne has been a Chancellor’s Fellow at the University of Edinburgh Centre for Clinical Brain Sciences since December 2020, leading a research group at the UK Dementia Research Institute

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Renzo Mancuso
Renzo Mancuso

The seventh SCOR Young European Researcher Prize for Research into Alzheimer’s disease was awarded to Renzo Mancuso of the Gothenburg University in Sweden. Renzo won the award for his findings on microglia and neuroinflammation, which play a central role in the pathogenesis of Alzheimer’s disease and other neurodegenerative disorders. A young Italian-Argentine biologist, Renzo Mancuso works with Pr. Bart de Strooper at the VIB UAntwerp Center for Molecular Neurology in the Netherlands. His primary focus has been on examining the underlying molecular mechanisms that drive Alzheimer’s disease (AD) and frontotemporal degeneration (FTD), with a special emphasis on inflammatory networks and particularly the contribution of microglia.
Click here to read Renzo's entry form.

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Federica Agosta
Federica Agosta

The 2019 SCOR Young European Researcher Prize for Research into Alzheimer’s disease was awarded to Dr Federica Agosta, medical doctor and researcher at the San Raffaele Hospital in Milan. Using MRI (magnetic resonance imaging) techniques, her work aims to identify functional and structural markers of degeneration to enable early diagnosis of Alzheimer’s and related disorders.
She is also particularly interested in young-onset Alzheimer’s disease. She has published more than 200 articles in specialist scientific journals. The jury of renowned European researchers was chaired by Professor Jean-François Dartigues of the Bordeaux Population Health Research Center.

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Rik Ossenkoppele
Rik Ossenkoppele

The 2018 SCOR Young European Researcher Prize for research into Alzheimer’s disease was awarded to Rik Ossenkoppele of the Alzheimer Center at the VU University Medical Center in Amsterdam, the Netherlands. 
A Dutch-born Doctor of Science, he is considered one of the most brilliant researchers of his generation. His main work has focused on new neuroimaging tracers – both amyloid markers and tau markers – that make it possible to identify lesions in patients’ brains during a PET scan. 

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Erik Portelius
Erik Portelius

On February 12, 2018, the 5th SCOR Young European Researcher Prize for Research into Alzheimer’s disease was presented to Erik Portelius of Sweden’s Gothenburg University, for his findings on a new biomarker that enables earlier detection of the condition. 
This new biomarker, a protein called neurogranin, paves the way for a better understanding of the disease. It allows doctors to estimate the extent of the damage to patients’ synapses and also to predict the rate of cognitive decline in patients with mild cognitive impairment. By measuring the new biomarker, the disease can be detected at an earlier stage than previously, since the loss of synapses is believed to occur early in the disease process, perhaps even earlier than neuronal loss. 

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Niklas Mattson
Niklas Mattson

The Scientific Committee of the French Alzheimer’s Research Foundation, comprised of eight European neurology professors, has named Dr. Niklas Mattson of Sweden’s Lund University as the winner of the 4th SCOR Young European Researcher Prize, which is financed by the SCOR Corporate Foundation for Science. Dr. Niklas Mattson’s original research on biomarkers has improved medical knowledge of disease mechanisms in the early stages of Alzheimer’s disease.
A biomarker can be defined as “a naturally occurring molecule, gene, or characteristic by which a particular pathological or physiological process, disease, etc. can be identified”. 

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Lawrence Rajendran
Lawrence Rajendran

The 3rd SCOR Young European Researcher Prize, financed by the SCOR Corporate Foundation for Science, was awarded to Dr Lawrence Rajendran of the University of Zurich.
Lawrence Rajendran’s remarkable work notably deals with the genes that predispose people to develop Alzheimer’s disease. For neurodegenerative diseases it is often impossible to isolate one responsible gene, which was previously the case for Alzheimer’s disease. However, the emergence of functional genomics methods and computational tools has led to advances in the understanding of the complex molecular networks underlying the disease.

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Rita Guerreiro
Rita Guerreiro

The 2014 SCOR Young European Researcher Prize for Research into Alzheimer’s disease was awarded to Rita Guerreiro, Researcher at the Department of Molecular Neuroscience, University College London (UCL).
This young researcher with Portuguese roots works in the Department of Molecular Neuroscience, University College London (UCL). She was selected for her work on the mutation of the TREM2 gene, which is implicated as a possible risk factor for Alzheimer’s disease and for certain generative diseases such as frontotemporal dementia.

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Florence Clavaguera
Florence Clavaguera

The 2013 SCOR Young European Researcher Prize for Research into Alzheimer’s disease was awarded to Florence Clavaguera, Researcher at the University Hospital Basel, Switzerland.
In partnership with SCOR, the French Alzheimer’s Research Foundation (Fondation Recherche Alzheimer) has created a Young European Researcher Prize. Worth EUR 10,000, this prize is designed to support and encourage promising research projects by young researchers.

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Publications by the prizewinners


More publications by Alberto Benussi are available on the National Library of Medicine website.


More publications by Axel Montagne are available on the National Library of Medicine website.


More publications by Renzo Mancuso are available on the National Library of Medicine website.


More publications by Federica Agosta are available on the National Library of Medicine website.

  • Amyloid-β-independent regulators of tau pathology in Alzheimer disease.
    van der Kant R, Goldstein LSB, Ossenkoppele R. Nat Rev Neurosci.
    2020 Jan;21(1):21-35. doi: 10.1038/s41583-019-0240-3. Epub 2019 Nov 28. PMID: 31780819 Review.
  • Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias.
    Chételat G, Arbizu J, Barthel H, Garibotto V, Law I, Morbelli S, van de Giessen E, Agosta F, Barkhof F, Brooks DJ, Carrillo MC, Dubois B, Fjell AM, Frisoni GB, Hansson O, Herholz K, Hutton BF, Jack CR Jr, Lammertsma AA, Landau SM, Minoshima S, Nobili F, Nordberg A, Ossenkoppele R, Oyen WJG, Perani D, Rabinovici GD, Scheltens P, Villemagne VL, Zetterberg H, Drzezga A. Lancet Neurol.
    2020 Nov;19(11):951-962. doi: 10.1016/S1474-4422(20)30314-8. PMID: 33098804 Review.
  • Clinicopathological correlations in behavioural variant frontotemporal dementia.
    Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW. Brain.
    2017 Dec 1;140(12):3329-3345. doi: 10.1093/brain/awx254. PMID: 29053860 Free PMC article.
  • The effect of physical activity on cognitive function in patients with dementia: A meta-analysis of randomized control trials.
    Groot C, Hooghiemstra AM, Raijmakers PG, van Berckel BN, Scheltens P, Scherder EJ, van der Flier WM, Ossenkoppele R.
    Ageing Res Rev. 2016 Jan;25:13-23. doi: 10.1016/j.arr.2015.11.005. Epub 2015 Nov 28. PMID: 26607411 Review.
  • Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
    Jansen WJ, Ossenkoppele R, Knol DL, Tijms BM, Scheltens P, Verhey FR, Visser PJ; Amyloid Biomarker Study Group, Aalten P, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BN, Bibeau K, Blennow K, Brooks DJ, van Buchem MA, Camus V, Cavedo E, Chen K, Chetelat G, Cohen AD, Drzezga A, Engelborghs S, Fagan AM, Fladby T, Fleisher AS, van der Flier WM, Ford L, Förster S, Fortea J, Foskett N, Frederiksen KS, Freund-Levi Y, Frisoni GB, Froelich L, Gabryelewicz T, Gill KD, Gkatzima O, Gómez-Tortosa E, Gordon MF, Grimmer T, Hampel H, Hausner L, Hellwig S, Herukka SK, Hildebrandt H, Ishihara L, Ivanoiu A, Jagust WJ, Johannsen P, Kandimalla R, Kapaki E, Klimkowicz-Mrowiec A, Klunk WE, Köhler S, Koglin N, Kornhuber J, Kramberger MG, Van Laere K, Landau SM, Lee DY, de Leon M, Lisetti V, Lleó A, Madsen K, Maier W, Marcusson J, Mattsson N, de Mendonça A, Meulenbroek O, Meyer PT, Mintun MA, Mok V, Molinuevo JL, Møllergård HM, Morris JC, Mroczko B, Van der Mussele S, Na DL, Newberg A, Nordberg A, Nordlund A, Novak GP, Paraskevas GP, Parnetti L, Perera G, Peters O, Popp J, Prabhakar S, Rabinovici GD, Ramakers IH, Rami L, Resende de Oliveira C, Rinne JO, Rodrigue KM, Rodríguez-Rodríguez E, Roe CM, Rot U, Rowe CC, Rüther E, Sabri O, Sanchez-Juan P, Santana I, Sarazin M, Schröder J, Schütte C, Seo SW, Soetewey F, Soininen H, Spiru L, Struyfs H, Teunissen CE, Tsolaki M, Vandenberghe R, Verbeek MM, Villemagne VL, Vos SJ, van Waalwijk van Doorn LJ, Waldemar G, Wallin A, Wallin ÅK, Wiltfang J, Wolk DA, Zboch M, Zetterberg H. JAMA.
    2015 May 19;313(19):1924-38. doi: 10.1001/jama.2015.4668. PMID: 25988462 Free PMC article.
  • Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease.
    Franzmeier N, Neitzel J, Rubinski A, Smith R, Strandberg O, Ossenkoppele R, Hansson O, Ewers M; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Nat Commun.
    2020 Jan 17;11(1):347. doi: 10.1038/s41467-019-14159-1. PMID: 31953405 Free PMC article.
  • PET Imaging of Tau Deposition in the Aging Human Brain.
    Schöll M, Lockhart SN, Schonhaut DR, O'Neil JP, Janabi M, Ossenkoppele R, Baker SL, Vogel JW, Faria J, Schwimmer HD, Rabinovici GD, Jagust WJ. Neuron.
    2016 Mar 2;89(5):971-982. doi: 10.1016/j.neuron.2016.01.028. PMID: 26938442 Free PMC article.
  • The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features.
    Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, La Joie R, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel BN, Miller BL, Barkhof F, Jagust WJ, Scheltens P, Seeley WW, Rabinovici GD. Brain.
    2015 Sep;138(Pt 9):2732-49. doi: 10.1093/brain/awv191. Epub 2015 Jul 2. PMID: 26141491 Free PMC article.
  • Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship.
    van Loenhoud AC, van der Flier WM, Wink AM, Dicks E, Groot C, Twisk J, Barkhof F, Scheltens P, Ossenkoppele R; Alzheimer's Disease Neuroimaging Initiative. Neurology.
    2019 Jul 23;93(4):e334-e346. doi: 10.1212/WNL.0000000000007821. Epub 2019 Jul 2. PMID: 31266904 Free PMC article.
  • Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.
    Bergeron D, Gorno-Tempini ML, Rabinovici GD, Santos-Santos MA, Seeley W, Miller BL, Pijnenburg Y, Keulen MA, Groot C, van Berckel BNM, van der Flier WM, Scheltens P, Rohrer JD, Warren JD, Schott JM, Fox NC, Sanchez-Valle R, Grau-Rivera O, Gelpi E, Seelaar H, Papma JM, van Swieten JC, Hodges JR, Leyton CE, Piguet O, Rogalski EJ, Mesulam MM, Koric L, Nora K, Pariente J, Dickerson B, Mackenzie IR, Hsiung GR, Belliard S, Irwin DJ, Wolk DA, Grossman M, Jones M, Harris J, Mann D, Snowden JS, Chrem-Mendez P, Calandri IL, Amengual AA, Miguet-Alfonsi C, Magnin E, Magnani G, Santangelo R, Deramecourt V, Pasquier F, Mattsson N, Nilsson C, Hansson O, Keith J, Masellis M, Black SE, Matías-Guiu JA, Cabrera-Martin MN, Paquet C, Dumurgier J, Teichmann M, Sarazin M, Bottlaender M, Dubois B, Rowe CC, Villemagne VL, Vandenberghe R, Granadillo E, Teng E, Mendez M, Meyer PT, Frings L, Lleó A, Blesa R, Fortea J, Seo SW, Diehl-Schmid J, Grimmer T, Frederiksen KS, Sánchez-Juan P, Chételat G, Jansen W, Bouchard RW, Laforce RJ, Visser PJ, Ossenkoppele R. Ann Neurol.
    2018 Nov;84(5):729-740. doi: 10.1002/ana.25333. PMID: 30255971 Free PMC article.


More publications by Rik Ossenkoppele are available on the National Library of Medicine website.


More publications by Erik Portelius are available on the National Library of Medicine website.


More publications by Niklas Mattsson are available on the National Library of Medicine website.


More publications by Lawrence Rajendran are available on the National Library of Medicine website.

  • The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders.
    Carmona S, Zahs K, Wu E, Dakin K, Bras J, Guerreiro R.
    Lancet Neurol. 2018 Aug;17(8):721-730. doi: 10.1016/S1474-4422(18)30232-1. Epub 2018 Jul 17. PMID: 30033062 Review.
  • TREM2 variants in Alzheimer's disease.
    Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J; Alzheimer Genetic Analysis Group.
    N Engl J Med. 2013 Jan 10;368(2):117-27. doi: 10.1056/NEJMoa1211851. Epub 2012 Nov 14. PMID: 23150934
  • Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease.
    Holstege H, Hulsman M, Charbonnier C, Grenier-Boley B, Quenez O, Grozeva D, van Rooij JGJ, Sims R, Ahmad S, Amin N, Norsworthy PJ, Dols-Icardo O, Hummerich H, Kawalia A, Amouyel P, Beecham GW, Berr C, Bis JC, Boland A, Bossù P, Bouwman F, Bras J, Campion D, Cochran JN, Daniele A, Dartigues JF, Debette S, Deleuze JF, Denning N, DeStefano AL, Farrer LA, Fernández MV, Fox NC, Galimberti D, Genin E, Gille JJP, Le Guen Y, Guerreiro R, Haines JL, Holmes C, Ikram MA, Ikram MK, Jansen IE, Kraaij R, Lathrop M, Lemstra AW, Lleó A, Luckcuck L, Mannens MMAM, Marshall R, Martin ER, Masullo C, Mayeux R, Mecocci P, Meggy A, Mol MO, Morgan K, Myers RM, Nacmias B, Naj AC, Napolioni V, Pasquier F, Pastor P, Pericak-Vance MA, Raybould R, Redon R, Reinders MJT, Richard AC, Riedel-Heller SG, Rivadeneira F, Rousseau S, Ryan NS, Saad S, Sanchez-Juan P, Schellenberg GD, Scheltens P, Schott JM, Seripa D, Seshadri S, Sie D, Sistermans EA, Sorbi S, van Spaendonk R, Spalletta G, Tesi N, Tijms B, Uitterlinden AG, van der Lee SJ, Visser PJ, Wagner M, Wallon D, Wang LS, Zarea A, Clarimon J, van Swieten JC, Greicius MD, Yokoyama JS, Cruchaga C, Hardy J, Ramirez A, Mead S, van der Flier WM, van Duijn CM, W…
    Nat Genet. 2022 Dec;54(12):1786-1794. doi: 10.1038/s41588-022-01208-7. Epub 2022 Nov 21. PMID: 36411364
  • Challenge accepted: uncovering the role of rare genetic variants in Alzheimer's disease.
    Khani M, Gibbons E, Bras J, Guerreiro R.
    Mol Neurodegener. 2022 Jan 9;17(1):3. doi: 10.1186/s13024-021-00505-9. PMID: 35000612
  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
    Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J.
    Nat Genet. 2009 Oct;41(10):1088-93. doi: 10.1038/ng.440. Epub 2009 Sep 6. PMID: 19734902
  • Genetics of Alzheimer's disease.
    Guerreiro R, Hardy J.
    Neurotherapeutics. 2014 Oct;11(4):732-7. doi: 10.1007/s13311-014-0295-9. PMID: 25113539
  • Genetic architecture of common non-Alzheimer's disease dementias.
    Guerreiro R, Gibbons E, Tábuas-Pereira M, Kun-Rodrigues C, Santo GC, Bras J.
    Neurobiol Dis. 2020 Aug;142:104946. doi: 10.1016/j.nbd.2020.104946. Epub 2020 May 19. PMID: 32439597
  • How understudied populations have contributed to our understanding of Alzheimer's disease genetics.
    Dehghani N, Bras J, Guerreiro R.
    Brain. 2021 May 7;144(4):1067-1081. doi: 10.1093/brain/awab028. PMID: 33889936
  • Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease.
    Guerreiro R, Bras J, Toombs J, Heslegrave A, Hardy J, Zetterberg H.
    Curr Genet Med Rep. 2015;3(1):19-25. doi: 10.1007/s40142-014-0062-6. PMID: 25664224
  • Complement receptor 1 (CR1) and Alzheimer's disease.
    Crehan H, Holton P, Wray S, Pocock J, Guerreiro R, Hardy J.
    Immunobiology. 2012 Feb;217(2):244-50. doi: 10.1016/j.imbio.2011.07.017. Epub 2011 Jul 23. PMID: 21840620


More publications by Rita Guerreiro are available on the National Library of Medicine website.


More publications by Florence Clavaguera are available on the National Library of Medicine website.